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Uric Acid Metabolism in Malignancy

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Cancer in Childhood

Abstract

Complications due to uric acid used to be very common in malignancy. In one series of patients with leukemia, 25% had uric acid levels above 12 mg.% at some time during their disease1. Almost all complications related to uric acid excretion can be prevented. Although hyperuricemia may occur with any malignancy, the difficulties in children arise primarily in association with acute leukemia and lymphosarcoma.

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References

  1. KRAKOFF, I. H. and MEYER, R. L.: Prevention of hyperuricemia in leukemia and lymphoma. JAMA, 193: I, 1965.

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  2. SINKS, L. E.. NEWTON, A. W.. Jr., NAGI, N. A. and STEVENSON, T. D.: A syndrome associated with extreme hyperuricemia in leukemia. J Pediair. 68: 578, 1966.

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  3. BAND, P. R., SILVERBERG, D. S. HENDERSON, J. E., ULAN, R. A., WENSEL, R. H, BANERJEE, T. K. and LITTLE, A. S.: Xanthine nephropathy in a patient with lymphosarcoma treated with allopurinol. N Engl J Med. 283: 354, 1970.

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© 1973 Ontario Cancer Treatment and Research Foundation

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Saunders, E.F. (1973). Uric Acid Metabolism in Malignancy. In: Godden, J.O. (eds) Cancer in Childhood. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2070-8_36

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  • DOI: https://doi.org/10.1007/978-1-4684-2070-8_36

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2072-2

  • Online ISBN: 978-1-4684-2070-8

  • eBook Packages: Springer Book Archive

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