Abstract
The gross configurational changes which mitochondria undergo during energization and deenergization were the experimental foundation stones for the conformational model which we first proposed in 1967.1–3 Out of these studies emerged the notion of the energized state of the transducing unit and the notion of coupling the relaxation of the energized unit either to the synthesis of ATP or to active transport.4 Implicit in the conformational model is the conservation of energy in a metastable state4,5 of the transducing unit rather than in a high-energy covalent intermediate.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
J. T. Penniston, R. A. Harris, J. Asai and D. E. Green. Proc. Nat. Acad. Sci. U.S.A., 59 (1968) 624.
R. A. Harris, J. T. Penniston, J. Asai and D. E. Green, Proc. Nat. Acad. Sci. U.S.A., 59 (1968) 830.
D. E. Green, J. Asai, R. A. Harris and J. T. Penniston, Arch. Biochem. Biophys., 125 (1968) 684.
D. E. Green and H. Baum, Energy and the Mitochondrion, Academic Press, New York, 1970, p. 77.
D. E. Green and D. H. MacLennan, Metabolic Pathways, 3rd Ed., Vol. 1, Academic Press, Inc., New York, 1967, p. 47.
J. D. Watson and F. H. C. Crick, Nature, 171 (1953) 737, 694.
G. Vanderkooi and D. E. Green, Proc. Nat. Acad. Sci. U.S.A., 66 (1970) 615.
G. Vanderkooi and M. Sundaralingam, Proc. Nat. Acad. Sci. U.S.A., 67 (1970) 233.
H. E. Huxley, Science, 164 (1969) 1356.
J. T. G. Overbeck and J. Lijklema, in: Electrophoresis, Theory, Methods and Applications,M. Bier (ed.), Academic Press, Inc., New York, 1959, Chap. 1.
H. A. Laitinen, Chemical Analysis: An Advanced Text and Reference, McGraw-Hill Book Company, Inc., New York, 1960, p. 66.
H. Fernandez-Moran, T. Oda, P. V. Blair and D. E. Green, J. Cell Biol., 22 (1964) 63.
K. Kopaczyk, J. Asai, D. W. Allmann, T. Oda and D. E. Green, Arch. Biochem. Biophys., 123 (1968) 602.
H. S. Penefsky, M. E. Pullman, A. Datta and E. Racker, J. Biol. Chem., 233 (1960) 3330.
J. O’M. Bockris and S. Srinivasan, Fuel Cells: Their Electrochemistry, McGraw-Hill Book Company, New York, 1969, p. 607.
A. B. Hart and G. J. Womack, Fuel Cells: Theory and Applications, Chapman and Hall, London, 1967.
V. P. Skulachev, FEES Letters, 11 (1970) 301.
G. Vanderkooi and D. E. Green, Bio Science, 21 (1971) 409.
E. F. Korman and H. Vande Zande, Fed. Abstracts, 27 (1968) 526.
R. E. Dickerson, T. Takano, D. Eisenberg, O. B. Kallai, L. Samson, A. Cooper and E. Margoliash, J. Biol. Chem., 246 (1971) 1511.
J. E. Falk, Porphyrins and Metalloporphyrins, B.B.A. Library, Vol. 2, Elsevier Publishing Company, Amsterdam, 1964, p. 53.
D. E. Green, D. C. Wharton, A. Tzagoloff, J. S. Rieske and G. P. Brierley, in: Oxidases and Related Redox Systems, T. E. King, H. S. Mason and M. Morrison (eds.), Vol. 2, John Wiley and Sons, Inc., New York, 1965, p. 1032.
A. Tzagoloff and P. Meagher, J. Biol. Chem., 246 (1971) 7328.
O. Hatase, T. Wakabayashi and D. E. Green, Configurational changes in submitochondrial particles (manuscript in preparation).
A. Tzagoloff, D. H. MacLennan and K. H. Byington, Biochemistry, 7 (1968) 1596.
D. E. Green and T. Wakabayashi (unpublished observation).
D. W. Allmann, J. Munroe, T. Wakabayashi, R. A. Harris and D. E. Green, Bio-energetics, 1 (1970) 87.
P. Mitchell and J. Moyle, in: Biochemistry of Mitochondria, E. C. Slater, Z. Kaninga and L. Wojtczak (eds.), Academic Press, Inc., London, 1967, p. 53.
J. H. Young, G. A. Blondin and D. E. Green, Proc. Nat. Acad. Sci. U.S.A., 68 (1971) 1364.
T. Takano, R. Swanson, O. B. Kallai and R. E. Dickerson, Conformational Changes Upon Reduction of Cytochrome c, Cold Spring Harbor Symposium on Quantitative Biology, June 1971.
D. E. Green and G. Vanderkooi, in: Physical Principles of Biological Membranes, G. Iverson and J. Lam (eds.), Gordon and Breach Science Publishers, Inc., New York, 1970, p. 287.
C. T. O’Konski and N. C. Stellwagen, Biophysical J., 5 (1965) 607.
W. Junge, H. M. Emrich and H. T. Witt, in: Physical Principles of Biological Membranes, Proceedings of the Coral Gables Conference, Snell, et al. (eds.), Gordon and Breach Science Publishers, New York, 1970, p. 383.
For a discussion of the ATP synthesis mechanism via a direct union of ADP and P;, see Korman and McLick in this issue.
D. Agin, Proc. Nat. Acad. Sci. U.S.A., 57 (1967) 1232.
J. A. Donlon and A. Rothstein, J. Membrane Biol., 1 (1969) 37.
L. Bass and W. J. Moore, Nature, 214 (1967) 393.
D. A. T. Dick, Cell Water, Butterworths, Inc., Washington, 1965, p. 5.
T. L. Hill, Proc. Nat. Acad. Sci. U.S.A., 58 (1967) 111.
C. R. Hackenbrock, Proc. Nat. Acad. Sci. U.S.A., 61 (1968) 598.
E. F. Korman, R. A. Harris, C. H. Williams, T. Wakabayashi, D. E. Green and E. Valdivia, Bioenergetics, 1 (1970) 387.
J. Asai, G. A. Blondin, W. J. Vail and D. E. Green, Arch. Biochem. Biophys., 132 (1969) 524.
M. J. Lee, R. A. Harris, T. Wakabayashi and D. E. Green, Bioenergetics, 2 (1971) 13.
T. Wakabayashi, J. M. Smoly and D. E. Green, Bioenergetics (1972) in press.
G. R. Hunter and G. P. Brierley, J. Cell Biol., 50 (1971) 250.
N. E. Weber and P. V. Blair, Biochem. Biophys. Res. Commun., 36 (1969) 987.
N. E. Weber and P. V. Blair, Biochem. Biophys. Res. Commun., 36 (1970) 821.
D. E. Green, N.Y. Acad. Sci.,Conference on Membrane structure and its Biological Applications, June 2–4, 1971 (in press).
G. Vanderkooi and R. A. Capaldi, N.Y. Acad. Sci., Conference on Membrane Structure and its Biological Applications,June 2–4, 1971, in press.
Y. Hatefi, Ada. Enzymol.,F. F. Nord (ed.), 25 (1963) 275.
D. E. Green and R. F. Brucker, Bio Science (1972), 22 (1972) 13.
H. Muirhead and M. F. Perutz, Cold Spring Harbor Symp. Quant. Biol., 28 (1963) 451.
J. C. Brooks, (unpublished observation).
E. F. Korman and J. McLick, Proc. Nat. Acad. Sci. U.S.A., 67 (1970) 1130.
J. T. Penniston (unpublished observation).
P. B. Garland, R. A. Clegg, P. A. Light and C. I. Raglan, in: Inhibitors: Tools in Cell Research, T. Bücher and H. Sies (eds.), Springer-Verlag, New York, 1969, p. 217.
J. A. Berden and E. C. Slater, Biochim. Biophys. Acta, 216 (1970) 237.
E. Racker, Mechanisms in Bioenergetics, Academic Press, New York, 1965, p. 145.
G. R. Drysdale and M. Cohen, J. Biol. Chem., 233 (1958) 1574.
P. G. Heytler, Biochemistry, 2 (1963) 357.
M. E. Pullman, H. S. Penefsky, A. Datta and E. Racker, J. Biol. Chem., 235 (1960) 3322.
E. Racker, J. Biol. Chem., 235 (1960) 148.
D. H. MacLennan and A. Tzagoloff, J. Biol. Chem., 241 (1966) 1933.
H. A. Lardy and G. Feldott, Ann. N.Y. Acad. Sci., 54 (1951) 636.
P. D. Boyer, in: Biological Oxidations, T. P. Singer (ed.), Interscience Publishers, New York, 1968, p. 210.
A. E. Senior and J. C. Brooks, Arch. Biochem. Biophys., 141 (1970) 257.
L. Ernster, C. P. Lee and S. Janda, in: Biochemistry of Mitochondria, E. C. Slater, Z. Kaninga and L. Wojtczak (eds.), Academic Press, London, 1967, p. 29.
H. A. Lardy, J. L. Connelly and D. Johnson, Biochemistry, 3 (1964) 1961.
G. D. Greville, in: Current Topics in Bioenergetics, Vol. 3, Academic Press, New York, 1969, p. I.
D. H. Jones and P. D. Boyer, J. Biol. Chem., 244 (1969) 5767.
P. D. Mitchell, Chemiosmotic Coupling. and Energy Transduction, Glynn Research Ltd., Bodmin, 1968.
J. H. Young, G. A. Blondin and D. E. Green, Proc. Nat. Acad. Sci. U.S.A., 68 (1971) 1364.
L. Packer and K. Utsumi, Arch. Biochem. Biophys., 131 (1969) 386.
R. S. Cockrell, E. J. Harris and B. C. Pressman, Biochemistry, 5 (1966) 2326.
C. Moore and B. C. Pressman, Biochem. Biophys. Res. Commun., 15 (1964) 562.
A. Fonyo, Biochem. Biophys. Res. Commun., 32 (1968) 624.
D. D. Tyler, Biochem. J., 111, 665 (1969).
H. Rasmussen, B. Chance and E. Ogata, Proc. Nat. Acad. Sci. U.S.A., 53 (1965) 1069.
M. Montai, B. Chance and C. P. Lee, J. Mem. Biol., 2 (1970) 201.
A. L. Lehninger, in Biomembranes, Vol. 2 (Ed. L. A. Manson ), Plenum Publishing Corp., New York, 1971 ), p. 147.
D. H. MacLennan (unpublished observation).
C. P. Lee and L. Ernster, in: Regulation of Metabolic Processes in Mitochondria, Tager, et al. (eds.), Elsevier Publishing Company, Amsterdam, 1966, p. 218.
H. R. Mahler and E. H. Cordes, Biological Chemistry, Harper and Row, Publishers, New York, 1966, p. 619.
K. Van Dam and H. F. Ter Welle, ref. 83, p. 235.
D. H. MacLennan, J. M. Smoly and A. Tzagoloff, J. Biol. Chem., 243 (1968) 1589.
C. P. Lee and L. Ernster, Biochem. Biophys. Acta., 81, (1964) 187.
P. Mitchell and J. Moyle, Nature, 208 (1965) 1205.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1972 Plenum Publishing Company Limited
About this chapter
Cite this chapter
Green, D.E., Ji, S. (1972). The Electromechanochemical Model of Mitochondrial Structure and Function. In: Avery, J. (eds) Membrane Structure and Mechanisms of Biological Energy Transduction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2016-6_15
Download citation
DOI: https://doi.org/10.1007/978-1-4684-2016-6_15
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-2018-0
Online ISBN: 978-1-4684-2016-6
eBook Packages: Springer Book Archive