Abstract
In the last few years considerable evidence has accumulated indicating that the secretion of pituitary gonadotropins in adult animals is regulated by multiple mechanisms. The existence of an inhibitory control exerted by the pineal gland and by its principles is now generally admitted (Fraschini 1969, Reiter and Fraschini 1969, Fraschini and Martini 1970); on the other hand, it has been shown that brain catecholamines may exert a tonic stimulatory effect on the secretion of these hormones (Barraclough and Sawyer 1957, 1959, Coppola et al. 1965, Schneider and McCann 1969, Kamberi et al. 1970). The aim of the studies here to be reported was to investigate whether these two mechanisms are active also in prepuberal rats.
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References
Andén, N. E., Corrodi, H., Dahlström, A., Fuxe, K. and Hökfelt, T. (1966): Effects of tyrosine hydroxylase inhibition on the amine levels of central monoamine neurons. Life Sci.5, 561–568.
Barraclough, C. A. and Sawyer, C. H. (1957): Blockade of the release of pituitary ovulating hormone in the rat by chlorpromazine and reserpine: possible mechanisms of action. Endocrinology61, 341–351.
Barraclough, C. A. and Sawyer, C. H. (1959): Induction of pseudopregnancy in the rat by reserpine and chlorpromazine. Endocrinology65, 563–571.
Benson, B. (1968): On the mechanism of compensatory ovarian hypertrophy. Anat. Rec.160, 314.
Benson, B., Sorrentino, S. and Evans, S. (1969): Increase in serum FSH following unilateral ovariectomy in the rat. Endocrinology84, 369–374.
Coppola, J. A., Leonardi, R. G., Lippmann, W., Perrine, J. W. and Ringler, I. (1965): Induction of pseudopregnancy in rats by depletors of endogenous catecholamines. Endocrinology77, 485–490.
Corbin, A. and Daniels, E. L. (1967): Changes in concentration of female rat pituitary FSH and stalk-median eminence follicle stimulating hormone releasing factor with age. Neuroendocrinology2, 304–314.
Corrodi, H., Fuxe, K. and Hökfelt, T. (1966): Refillment of the catecholamine stores with 3,4-dihydroxyphenylalanine after depletion induced by inhibition of tyrosine-hydroxylase. Life Sci. 5, 605–611.
Creveling, C. R., Daly, J., Tokuyama, T. and Witkop, B. (1968): The combined use of α-methyltyrosine and threo-dihydroxyphenylserine selective reduction of dopamine levels in the central nervous system. Biochem. Pharmacol.17, 65–70.
D’Angelo, A. and Kravatz, A. S. (1960): Gonadotropine hormone function in persistent estrous rats with hypothalamic lesions. Proc. Soc. exp. Biol. (N. Y.) 104, 130–133.
Fraschini, F. (1969): The pineal gland and the control of LH and FSH secretion. In: Progress in Endocrinology. Ed. by C. Gual. Excerpta Medica, Amsterdam. pp. 637–644.
Fraschini, F. and Martini, L. (1970): Rhythmic phenomena and pineal principles. In: The Hypothalamus. Ed. by L. Martini, M. Motta and F. Fraschini. Academic Press, New York. pp. 529–549.
Greep, R. O. (1961): Physiology of the anterior hypophysis in relation to reproduction. In: Sex and Internal Secretions. Ed. by W. C. Young and G. W. Comer. Williams and Wilkins, Baltimore, pp. 240–301.
Kamberi, I. A., Schneider, H. P. G. and McCann, S. M. (1970): Action of dopamine to induce release of FSH-releasing factor (FRF) from hypothalamic tissue “in vitro”. Endocrinology86, 278–284.
Ramirez, V. and Sawyer, H. (1966): Changes in hypothalamic luteinizing hormone releasing factor (LHRF) in the female rat during puberty. Endocrinology78, 958–964.
Reiter, R. J. and Fraschini, F. (1969): Endocrine aspects of the mammalian pineal gland. Neuroendocrinology5, 219–255.
Schneider, H. P. G. and McCann, S. M. (1969): Possible role of dopamine as transmitter to promote discharge of LH-releasing factor. Endocrinology85, 121–132.
Spector, S., Sjoerdsma, A. and Udenfriend, S. (1965): Blockade of endogenous norepinephrine synthesis by α-methyl-tyrosine, an inhibitor of tyrosine hydroxylase. J. Pharmacol, exp. Ther.147, 86–95.
Watanabe, S. and McCann, S. M. (1969): Alterations in pituitary follicle-stimulating hormone (FSH) and hypothalamic FSH-releasing factor (FSH-RF) during puberty. Proc. Soc. exp. Biol. (N. Y.) 132, 195–201.
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© 1973 Akadémiai Kiadó, Budapest, Hungary
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Fraschini, F., Collu, R., Müller, E.E. (1973). Mechanisms Controlling Pituitary Gonadotropin Secretion in Prepuberal Rats. In: Lissák, K. (eds) Hormones and Brain Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2007-4_22
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DOI: https://doi.org/10.1007/978-1-4684-2007-4_22
Publisher Name: Springer, Boston, MA
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