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Hypothalamic Mechanisms Controlling Anterior Pituitary Functions

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Hormones and Brain Function

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Abstract

It is now generally accepted that the central nervous system (CNS) plays an essential role in the regulation of many endocrine functions and that the hypothalamus is the crucial element of such regulation (Mangili et al. 1966, Martini et al. 1968a, Mess and Martini 1968, Motta et al. 1969a). The key position of the hypothalamus is due to its strategic location in close contact with the anterior pituitary gland, and to the fact that this region of the brain contains particular neurons which synthesize the chemical messengers necessary for stimulating or for inhibiting the anterior pituitary (the so-called hypothalamic releasing and inhibitory factors), as well as feedback receptors whose activity is modified by hormonal influences (Mangili et al. 1966, Martini et al. 1968a, Mess and Martini 1968; Motta et al. 1969a).

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References

  • Anton-Tay, F., Pelham, R. W. and Wurtman, R. J. (1969): Increased turnover of 3H-norepinephrine in rat brain following castration or treatment with ovine follicle-stimulating hormone. Endocrinology84, 489–492.

    Article  Google Scholar 

  • Baulieu, E. E., Lasnitzki, J. and Robel, P. (1969): Testosterone metabolism in rat prostate grown in organ culture and hormone action. In: Advances in the Biosciences. Vol. III. Ed. by G. Raspé. Pergamon, Oxford-Vieweg, Braunschweig. pp. 169–174.

    Google Scholar 

  • Beyer, C. and Sawyer, C. H. (1969): Hypothalamic unit activity related to control of the pituitary gland. In: Frontiers in Neuro endocrinology. Ed. by W. F. Ganong and L. Martini. Oxford University Press, New York. pp. 255–287.

    Google Scholar 

  • Bruchovsky, N. and Wilson, J. D. (1968): The conversion of testosterone to 5-androstan-17β-ol-3-one by rat prostate “in vivo” and “in vitro”. J. biol. Chem.243, 2012–2021.

    PubMed  CAS  Google Scholar 

  • Corbin, A., Mangili, G., Motta, M. and Martini, L. (1965): Effect of hypothalamic and mesencephalic steroid implantations on ACTH feedback mechanisms. Endocrinology76, 811–818.

    Article  PubMed  CAS  Google Scholar 

  • Corbin, A., Daniels, E. L. and Milmore, J. E. (1970): An “internal” feedback mechanism controlling follicle stimulating hormone releasing factor. Endocrinology86, 735–743.

    Article  PubMed  CAS  Google Scholar 

  • David, M. A., Fraschini, F. and Martini, L. (1965a): An in vivo method for evaluating the hypothalamic follicle stimulating hormone releasing factor. Experientia (Basel)21, 483.

    Article  CAS  Google Scholar 

  • David, M. A., Fraschini, F. and Martini, L. (1965b): Control of LH secretion: role of a “short” feedback mechanism. Endocrinology78, 55–60.

    Article  Google Scholar 

  • Davidson, J. M. (1969): Feedback control of gonadotropin secretion. In: Frontiers in Neuroendocrinology, 1969. Ed. by W. F. Ganong and L. Martini. Oxford University Press, New York. pp. 343–388.

    Google Scholar 

  • Davidson, J. M. and Smith, E. R. (1967): Testosterone feedback in the control of somatic and behavioral aspects of male reproduction. In: Hormonal Steroids. Ed. by L. Martini, F. Fraschini and M. Motta. Excerpta Medica, Amsterdam, pp. 805–813.

    Google Scholar 

  • Desjardins, O. (1969): Alteration of hypophyseal LH and FSH release by exogenous LH and FSH in orchidectomized mice. Proc. Soc. exp. Biol. (N.Y.)130, 535–538.

    CAS  Google Scholar 

  • Fang, S. and Liao, S. (1969): Dihydrotestosterone binding by androphilic proteins of rat ventral prostate. Fed. Proc.28, 846.

    Google Scholar 

  • Fraschini, F., Motta, M. and Martini, L. (1966): Methods for the evaluation of hypothalamic hypophysiotropic principles. In: Methods in Drug Evaluation. Ed. by P. Mantegazza and F. Piccinini. North-Holland Publishing Company, Amsterdam. pp. 424–457.

    Google Scholar 

  • Fraschini, F., Motta, M. and Martini, L. (1968): A “short” feedback mechanism controlling FSH secretion. Experientia (Basel)24, 270–271.

    Article  CAS  Google Scholar 

  • Fuxe, K. and Hökfelt, T. (1969): Catecholamines in the hypothalamus and the pituitary gland. In: Frontiers in Neuroendocrinology, 1969. Ed. by W. F. Ganong and L. Martini. Oxford University Press, New York. pp. 47–96.

    Google Scholar 

  • Ganong, W. F. and Lorenzen, L. (1967): Brain neurohumors and endocrine function. In: Neuroendocrinology. Vol. 2. Ed. by L. Martini and W. F. Ganong. Academic Press, New York. pp. 583–640.

    Google Scholar 

  • Geschwind, I. I. (1969): Mechanism of action of releasing factors. In: Frontiers in Neuroendocrinology, 1969. Ed. by W. F. Ganong and L. Martini. Oxford University Press, New York. pp. 389–431.

    Google Scholar 

  • Gloyna, R. E. and Wilson, J. D. (1969): A comparative study of the conversion of testosterone to 17β-hydroxy-5α-androstan-3-one (dihydroxy-testosterone) by prostate and epididymis. J. clin. Endocr.29, 970–977.

    Article  PubMed  CAS  Google Scholar 

  • Halász, B. (1969): The endocrine effects of isolation of the hypothalamus from the rest of the brain. In: Frontiers in Neuroendocrinology, 1969. Ed. by W. F. Ganong and L. Martini. Oxford University Press, New York. pp. 307–342.

    Google Scholar 

  • Harding, B. W. and Samuels, L. T. (1962): The uptake and subcellular distribution of C14 labelled steroid in rat ventral prostate following “in vivo” administration of testosterone-4-C14. Endocrinology70, 109–118.

    Article  PubMed  CAS  Google Scholar 

  • Hyyppä, M. and Motta, M. (1969): “Ultra-short” feedback control of the secretion of hypothalamic releasing factors. Scand. J. clin. Lab. Invest.23, Suppl. 108, 39.

    Google Scholar 

  • Hyyppä, M. and Valavaara, M. (1970): The effect of castration and hypophysectomy on the content of noradrenaline and serotonin in the hypothalamus of the rat. Experientia (Basel)26, 193–194.

    Article  Google Scholar 

  • Hyyppä, M., Motta, M. and Martini, L. (1971): Ultrashort feedback control of follicle stimulating hormone releasing factor secretion. Neuroendocrinology7, 227–235.

    Article  PubMed  Google Scholar 

  • Jaffe, R. B. (1969): Testosterone metabolism in target tissues: hypothalamic and pituitary tissues of the adult rat and human fetus, and the immature rat epiphysis. Steroids14, 483–499.

    Article  PubMed  CAS  Google Scholar 

  • Kamberi, I. A. and McCann, S. M. (1969): Effect of testosterone implants in the anterior pituitary (AP) of FSH secretion. Fed. Proc.28, 382.

    Google Scholar 

  • Kastin, A. J. and Schally, A. V. (1967): MSH activity in pituitaries of rats treated with hypothalamic extracts from various animals. Gen. comp. Endocr.8, 344–347.

    Article  PubMed  CAS  Google Scholar 

  • Katz, S. H., Molitch, M. and McCann, S. M. (1969): Effect of hypothalamic implants of GH on anterior pituitary weight and GH concentration. Endocrinology85, 725–734.

    Article  PubMed  CAS  Google Scholar 

  • Kawakami, M. and Sawyer, C. H. (1969): Effects of FSH on multiple unit activity in the rat hypothalamus. Anat. Rec.163, 308–315.

    Google Scholar 

  • Kniewald, Z., Massa, R. and Martini, L. (1971): Conversion of testosterone into 5α-androstan-17β-ol-3-one at the anterior pituitary and hypothalamic level. In: Hormonal Steroids. Ed. by V. H. T. James and L. Martini. Excerpta Medica, Amsterdam. pp. 946–953.

    Google Scholar 

  • Kobayashy, H. and Matsui, T. (1969): Fine structure of the median eminence and its functional significance. In: Frontiers in Neuroendocrinology, 1969. Ed. by W. F. Ganong and L. Martini. Oxford University Press, New York. pp. 3–46.

    Google Scholar 

  • Kobayashy, T. and Kato, J. (1968): Short feedback mechanisms in the control of pituitary hormone secretion. Saishin Jgaku23, 1037–1047.

    Google Scholar 

  • Krulich, L., Dhariwal, A. P. S. and McCann, S. M. (1968): Stimulatory and inhibitory effects of purified hypothalamic extracts on growth hormone release from rat pituitary “in vitro”. Endocrinology83, 783–790.

    Article  PubMed  CAS  Google Scholar 

  • Libertun, C., Mogtjilevsky, J. A., Schiaffini, O., and Foglia, V. (1969): Effect of hypophysectomy on the oxidative and glycolytic metabolism of hypothalamus. Experientia (Basel)25, 196–197.

    Article  CAS  Google Scholar 

  • Mainwaring, W. I. P. (1969): A soluble androgen receptor in the cytoplasm of rat prostate. J. Endocr.45, 531–541.

    Article  PubMed  CAS  Google Scholar 

  • Mangili, G., Motta, M. and Martini, L. (1966): Control of adrenocorticotropic hormone secretion. In: Neuroendocrinology. Vol. 1. Ed. by L. Martini and W. F. Ganong. Academic Press, New York. pp. 297–370.

    Google Scholar 

  • Martini, L., Fraschini, F. and Motta, M. (1968a): Neural control of anterior pituitary functions. Recent. Progr. Hormone Res.24, 439–496.

    PubMed  CAS  Google Scholar 

  • Martini, L., Fraschini, F. and Motta, M. (1968b): Comments on “long” and “short” feedback loops. In: Endocrinology and Human Behaviour. Ed. by R. P. Michael. Oxford University Press, London. pp. 175–187.

    Google Scholar 

  • McCann, S. M. and Dhariwal, A. P. S. (1966): Hypothalamic releasing factors and the neurovascular link between the brain and the anterior pituitary. In: Neuroendocrinology. Vol. 1. Ed. by L. Martini and W. F. Ganong. Academic Press, New York. pp. 261–296.

    Google Scholar 

  • Meites, J. (1966): Control of mammary growth and lactation. In: Neuroendocrinology. Vol. 1. Ed. by L. Martini and W. F. Ganong. Academic Press, New York. pp. 669–707.

    Google Scholar 

  • Mess, B. and Martini, L. (1968): The central nervous system and the secretion of anterior pituitary trophic hormones. In: Recent Advances in Endocrinology. Ed. by V. M. T. James. Churchill, London. pp. 1–49.

    Google Scholar 

  • Mess, B., Fraschini, F., Motta, M. and Martini, L. (1967): The topography of the neurons synthesizing the hypothalamic releasing factors. In: Hormonal Steroids. Ed. by L. Martini, F. Fraschini and M. Motta. Excerpta Medica, Amsterdam. pp. 1004–1013.

    Google Scholar 

  • Motta, M. (1969): The brain and the physiological interplay of long and short feedback systems. In: Progress in Endocrinology. Ed. by C. Gual. Excerpta Medica, Amsterdam. pp. 523–531.

    Google Scholar 

  • Motta, M., Mangili, G. and Martini, L. (1965): A “short” feedback loop in the control of ACTH secretion. Endocrinology77, 392–395.

    Article  PubMed  CAS  Google Scholar 

  • Motta, M., Fraschini, F., Giuliani, G. and Martini, L. (1968): The central nervous system, estrogen and puberty. Endocrinology83, 1101–1107.

    Article  PubMed  CAS  Google Scholar 

  • Motta, M., Fraschini, F. and Martini, L. (1969a): “Short” feedback mechanisms in the control of anterior pituitary function. In: Frontiers in Neuroendocrinology, 1969. Ed. by W. F. Ganong and L. Martini. Oxford University Press, New York. pp. 211–253.

    Google Scholar 

  • Motta, M., Sterescu, N., Piva, F. and Martini, L. (1969b): The participation of “short” feedback mechanisms in the control of ACTH and TSH secretion. Acta neurol. belg.69, 501–507.

    CAS  Google Scholar 

  • Motta, M., Piva, F., Fraschini, F. and Martini, L. (1970a): “Pituitary depletion methods” for the bioassay of hypothalamic releasing factors. In: Hypophysiotropic Hormones of the Hypothalamus: Assay and Chemistry. Ed. by J. Meites. Williams and Wilkins, Baltimore. pp. 44–59.

    Google Scholar 

  • Motta, M., Piva, F., Tima, L., Zanisi, M. and Martini, L. (1970b): Feedback mechanisms and the control of the secretion of the hypothalamic releasing factors. Mem. Soc. Endocr.18, 407–422.

    Google Scholar 

  • Motta, M., Piva, F. and Martini, L. (1970c): The hypothalamus as the center of endocrine feedback mechanisms. In: The Hypothalamus. Ed. by L. Martini, M. Motta and F. Fraschini. Academic Press, New York. pp. 463–489.

    Google Scholar 

  • Negro-Vilar, A., Dickerman, E. and Meites, J. (1968): FSH releasing factor activity in plasma of rats after hypophysectomy and continuous light. Endocrinology82, 939–944.

    Article  PubMed  CAS  Google Scholar 

  • Negro-Vilar, A., Dickerman, E. and Meites, J. (1969): Removal of plasma FSH-RF activity in hypophysectomized rats by testosterone propionate or reserpine. Endocrinology83, 1349–1352.

    Article  Google Scholar 

  • Ojeda, S. R. and Ramirez, V. D. (1970): Failure of estrogen to block compensatory ovarian hypertrophy in prepuberal rats bearing medial basal hypothalamic FSH implants. Endocrinology86, 50–56.

    Article  PubMed  CAS  Google Scholar 

  • Piva, F., Sterescu, N., Zanisi, M. and Martini, L. (1969): Non-steroidal antifertility agents affecting brain mechanisms. Bull. Wld. Hlth. Org.41, 275–288.

    CAS  Google Scholar 

  • Reichlin, S. (1966): Control of thyrotropic hormone secretion. In: Neuroendocrinology. Vol. 1. Ed. by L. Martini and W. F. Ganong. Academic Press, New York. pp. 445–536.

    Google Scholar 

  • Roy, S. F., Jr. and Laumas, K. R. (1969): l,2-3H-Testosterone: distribution and uptake in neural and genital tissues of intact male, castrated male and female rats. Acta Endocr. (Kbh.)61, 629–640.

    CAS  Google Scholar 

  • Saito, T., Sawano, S., Arimura, A. and Schally, A. V. (1967): Follicle stimulating hormone-releasing activity in peripheral blood. Endocrinology81, 1226–1230.

    Article  PubMed  CAS  Google Scholar 

  • Samperez, S., Thieulant, M. L. and Jouan, P. (1969): Mise en évidence d’une association macromoléculaire de la testostérone l-2-3H- dans l’hypophyse antérieure et l’hypothalamus du rat normal et castré. C.B. Acad. Sci. (Paris)268, 2967.

    Google Scholar 

  • Sawyer, C. H. (1967): Effects of hormonal steroids on certain mechanisms in the adult brain. In: Hormonal Steroids. Ed. by L. Martini, F. Fraschini and M. Motta. Excerpta Medica, Amsterdam. pp. 123–135.

    Google Scholar 

  • Schneider, H. P. G. and McCann, S. M. (1969): Possible role of dopamine as transmitter to promote discharge of LH-releasing factor. Endocrinology85, 121–132.

    Article  PubMed  CAS  Google Scholar 

  • Shimazaki, J., Kurihara, H., Ito, Y. and Shida, K. (1965): Testosterone metabolism in prostate; formation of androstan-17β-ol-3-one and androst-4-ene-3,17-dione and the inhibitory effect of natural and synthetic oestrogens. Gunma J. med. Sci.14, 313–323.

    PubMed  CAS  Google Scholar 

  • Sholiton, L. J. and Werk, E. E. (1969): The less-polar metabolites produced by incubation of testosterone-4-14C with rat on bovine brain. Acta Endocr. (Kbh.)61, 641–648.

    CAS  Google Scholar 

  • Steelman, S. L. and Pohley, F. M. (1953): Assay of the follicle stimulating hormone based on the augmentation with human chorionic gonadotropin. Endocrinology53, 604–616.

    Article  PubMed  CAS  Google Scholar 

  • Steiner, F. A., Rue, K. and Akert, K. (1967): Steroid sensitive neurones in rat brain: anatomical localization and response to neurohumours and ACTH. Brain Res.12, 74–85.

    Article  Google Scholar 

  • Szentágothai, J., Flerkó, B., Mess, B. and Halász, B. (1968): Hypothalamic Control of the Anterior Pituitary. Akadémiai Kiadó, Budapest.

    Google Scholar 

  • Terasawa, E., Whitmoyer, D. I. and Sawyer, C. H. (1969): Effects of luteinizing hormone on multiple unit activity in the rat hypothalamus. Amer. J. Physiol.217, 1119–1126.

    PubMed  CAS  Google Scholar 

  • Tima, L., Motta, M. and Martini, L. (1969): Effect of “hypothalamic deafferentation” on hypothalamic follicle stimulating hormone releasing factor (FSH-RF) and on pituitary FSH. In: Program of the 51st Meeting of Endocrine Society. p. 194.

    Google Scholar 

  • Tveter, K. J. and Aakvag, A. (1969): Uptake and metabolism “in vivo” of testosterone-1,2-3H by accessory sex organs of male rats: influence of some hormonal compounds. Endocrinology85, 683–689.

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Pharmacology, University of Milan, Milan, Italy

    L. Martini

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  1. L. Martini
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  1. University Medical School, Pécs, Hungary

    K. Lissák (Member of the Hungarian Academy of Sciences, Professor of Physiology) (Member of the Hungarian Academy of Sciences, Professor of Physiology)

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© 1973 Akadémiai Kiadó, Budapest, Hungary

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Martini, L. (1973). Hypothalamic Mechanisms Controlling Anterior Pituitary Functions. In: Lissák, K. (eds) Hormones and Brain Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2007-4_13

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  • DOI: https://doi.org/10.1007/978-1-4684-2007-4_13

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