Abstract
Dr. William Wallace Scott has focused a considerable portion of his efforts toward defining the clinical parameters and physiological factors which are important in understanding and controlling the growth of the prostate gland. Dr. Scott defined the ultimate clinical goal in his statement, “What a glorious day it will be for urology when we can shrink the benign nodular hyperplastic prostate, quiet the carcinomatous one and increase the libido and potentia all with a tablet. Oh happy day!”(1) Dr. Scott has initiated this long and difficult journey through a series of contributions which have formed a systematic framework for the evaluation and search for new inhibitors of prostatic growth(1–18). This has been exemplified by his leadership in the recent development of antiandrogenic drugs, which introduce a great deal of promise as a new approach for the effective treatment of benign nodular prostatic hyperplasia and prostatic carcinoma(12,14,17,18).
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References
Scott, W. W., Hopkins, W. J., Lucas, W. M., and Tesar, C. A search for Inhibitors of prostatic growth stimulators. J. Urol. 77:652, 1957
Grayhack, J. T., Bunce, P. L., Kearns, J. W., and Scott, W. W. Influence of the pituitary on prostatic response to androgens in the rat. Bull. Johns Hopkins Hosp. 96: 154, 1955.
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Burt, F. B., Finney, R. P., and Scott, W. W. Steroid response to therapy in prostatic cancer. J. Urol. 77: 485, 1957.
Goodwin, D. A., Rasmussen-Taxdal, D. S., Ferreira, A. A., and Scott, W. W. Estrogen inhibition of androgen-maintained prostatic secretion in the hypophysectomized dog. J. Urol. 86: 134, 1961.
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Scott, W. W. Growth and development of the human prostate. In Biology of the Prostate and Related Tissues, U.S.P.H. Monograph No. 12, p. 111, 1963.
Walton, K. N., Schirmer, H. K. A., and Scott, W. W. The effect of prolonged stimulation with pilocarpine upon secretory and metabolic activity of normal dog prostate gland. Invest. Urol. 1: 23, 1963.
Walton, K. N., Schirmer, K. A., and Scott, W. W. Cholinesterase activity in the dog prostate gland. Invest. Urol. 1: 307, 1964.
Kirchheim, D., Gyorkey, F., Brandes, D., and Scott, W. W. Histochemistry of the normal, hyperplastic, and neoplastic human prostate gland. Invest. Urol. 1: 403, 1964.
Schirmer, K. A., Walton, K. N., and Scott, W. W. Prostatic epithelial cells: Their preparation and catalase activity. Invest. Urol. 1: 301, 1964.
Tesar, C., and Scott, W. W. A search for inhibitors of prostate growth stimulators. Invest. Urol. 1: 482, 1964.
Robson, M. C., and Scott, W. W. Effect of portal diversion of testicular blood on prostatic secretion in the dog. Invest. Urol. 1: 92, 1964.
Bridge, R. W., and Scott, W. W. A new antiandrogen, SH-714, Invest. Urol. 2: 99, 1964.
Brandes, D., Kirchheim, D., and Scott, W. W. Ultrastructure of the human prostate: Normal and neoplastic. Lab. Invest. 13: 1541, 1964.
Campbell, E. W., Jr., and Scott, W. W. The effect of thyroxine and thiouracil on prostatic growth in the castrate male rat. Invest. Urol. 2: 387, 1965.
Kirchheim, D., and Scott, W. W. The effect of castration and sex hormones upon aminopeptidase and phosphotases of the rat prostate. Invest. Urol. 2: 393, 1965.
Scott, W. W., and Schirmer, H. K. A. A new oral progestational steroid effective in the treatment of prostatic cancer. Trans. Am. Assoc. Genitourin. Surg. 58: 54, 1966.
Scott, W. W., and Wade, J. C. Medical treatment of benign nodular prostatic hyperplasia with cyproterone acetate. J. Urol. 101: 81, 1969.
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Fang, S., and Liao, S. Antagonistic action of anti-androgens on the formation of a specific dihydrotestosterone receptor protein complex in rat ventral prostate. Molec. Pharmacol. 5: 420, 1969.
Stein, J. M., and Eisenfeld, A. J. Androgen accumulation and binding to macromolecules in seminal vesticles: Inhibition by cyproterone acetate. Science 166: 233, 1969.
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Liao, S., Barton, R. W., and Lin, A. H. Differential synthesis of ribonucleic acid in prostatic nuclei: Evidence for selective gene transcription induced by androgens. Proc. Natl. Acad. Sci. 55: 1593, 1966.
Liao, S., and Fang, S. Receptor-proteins for androgens and the mode of action of androgens on gene transcription in ventral prostate. Vitamins and Hormones 27: 17, 1970.
Coffey, D. S., Shimazaki, J., and Williams-Ashman, H. G. Polymerization of deoxyribonucleotides in relation to androgen-induced prostatic growth. Arch. Biochem. Biophys. 24: 184, 1968.
Tesar, C., and Scott, W. W. A search for inhibitors of prostatic growth stimulators. Invest. Urol. 1: 482, 1964.
Bridge, R. W., and Scott, W. W. A new antiandrogen, SH-714. Invest. Urol. 2: 99, 1964.
Scott, W. W., and Schirmer, H. K. A. A new oral progestational steroid effective in treating prostatic cancer. Trans. Am. Assoc. Genitourin. Surg. 58: 54, 1966.
Scott, W. W., and Wade, J. C. Medical treatment of benign nodular prostatic hyperplasia with cyproterone acetate. J. Urol. 101: 81, 1969.
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© 1972 Plenum Press, New York
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Carter, M.F., Chung, L.W.K., Coffey, D.S. (1972). The Temporal Requirements for Androgens During the Cell Cycle of the Prostate Gland. In: Urological Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1941-2_5
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DOI: https://doi.org/10.1007/978-1-4684-1941-2_5
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