Abstract
We have used both differential renal function studies and measurements of plasma renin activity in the evaluation of our hypertensive patients during the past few years. Using the renin method of Boucher(1), and the technique of differential function studies described earlier(2,3), we can make the following general comparisons:
The advantages of measurement of renal vein renins over differential function studies are that (a) samples can be collected with relative ease and safety and (b) renin determinations are the only way to asscess the significance of unilaterally small kidneys with parenchymal disease but normal main renal arteries.
Measurements of plasma renin activity are now widely used in the evaluation of patients with potentially curable renovascular hypertension, and justifiably so. But a short decade ago, differential renal function studies were received with equal enthusiasm. What are the relative merits of these two methodologies? Because my first research efforts under the guidance of Dr. William Wallace Scott were in the field of renovascular hypertension, I have chosen this subject as my part of the Festschrift in his honor.
Supported by U.S. Public Health Service Training Grant No. 5 TOI AM 05513.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Boucher, R., Veyrat, R., de Champlain, J., and Genest, J. New procedures for measurement of human plasma angiotensin and renin activity levels. Canad. Med. Assoc. J. 90: 194, 1964.
Stamey, T. A., Nudelman, I. J., Good. P. H., Schwentker, F. N., and Hendricks, F. Functional characteristics of renovascular hypertension. Medicine 40: 347, 1961.
Stamey, T. A. Reno vascular Hypertension, Williams and Wilkins, Baltimore, 1963.
Phillips, R. A., Dole, V. P., Hamilton, P. B., Emerson, K., Jr., Archibald, R. M., and Van Slyke, D. D. Effects of acute hemorrhagic and traumatic shock on renal function of dogs. Am. J. Physiol. 145: 314, 1946.
Assaykeen, T. A., Otsuka, K., and Ganong, W. F. Rate of disappearance of exogenous dog renin from the plasma of nephrectomized dogs. Proc. Soc. Exptl. Biol. Med. 127: 306, 1968.
Boyd, G. W., Fitz, A. E., Adamson, A. R., and Peart, W. S. Radioimmunoassay determination of plasma-renin activity. Lancet 2: 213, 1969.
Cohen, E. L., Conn, J. W., and Rovner, D. R. Postural augmentation of plasma renin activity and aldosterone excretion in normal people. J. Clin. Invest. 46: 418, 1967.
Gordon, R. D., Wolfe, L. K., Island, D. P., and Liddle, G. W. A diurnal rhythm in plasma renin activity in man. J. Clin. Invest. 45: 1587, 1966.
Brown, J. J., Davies, D. L., Lever, A. F., and Robertson, J. I. S. Influence of sodium loading and sodium depletion on plasma renin in man. Lancet 2: 278, 1963.
McKenzie, J. K., Ryan, J. W., and Lee, M. R. Effect of laparotomy on plasma renin activity in the rabbit. Nature 215: 542, 1967.
Vander, A. J. Control of renin release. Physiol. Rev. 47: 359, 1967.
Mannick, J. A., Huvos, A., and Hollander, W. E. Post-hydralazine renin release in the diagnosis of renovascular hypertension. Ann. Surg. 170: 409, 1969.
Mohammed, S., Fasola, A. F., Privitera, P. J., Lipicky, R. J., Martz, B. L., and Gaffney, T. E. Effect of methyldopa on plasma renin activity in man. Circ. Res. 25: 543, 1969.
Strong, C. G., Hunt, J. C., Sheps, S. G., Tucker, R. M., and Bematz, P. E. Renal venous renin activity: Enhancement of sensitivity of lateralization by sodium depletion Am. J. Cardiol. 27: 602, 1971.
Simmons, J. L., and Michelakis, A. M. Renovascular hypertension: The diagnostic value of renal vein renin ratios. J. Urol. 104: 497, 1970.
Kaufman, J. J., Lupu, A. N., Franklin, S., and Maxwell, M. H. Diagnostic and predicative value of renal vein renin activity in renovascular hypertension. J. Urol. 103: 702, 1970.
Gunnells, J. C., McGuffin, W. L., Jr., Johnsrude, I., and Robinson, R. R. Peripheral and renal venous plasma renin activity in hypertension. Ann. Int. Med. 71: 555, 1969.
Michelakis, A. M., and Simmons, J. Effect of posture on renal vein renin activity in hypertension: Its implications in the management of patients with renovascular hypertension. J.A.M.A. 208: 659, 1969.
Kaneko, Y., Ikeda, T., Takeda, T., and Ueda, H. Renin release during acute reduction of arterial pressure in normotensive subjects and patients with renovascular hypertension. J. Clin. Invest. 46: 705, 1967.
Gross, F., Schaechtelin, G., Brunner, H., and Peters, G. The role of the renin—angiotensin system in blood pressure regulation and kidney function. Canad. Med. Assoc. J. 90: 258, 1964.
Stamey, T. A. Some observations on the filtration fraction, on the transport of sodium and water in the ischemic kidney, and on the prognostic importance of R.P.F. to the contralateral kidney in renovascular hypertension. In Ciba Foundation Symposium on Antihypertensive Therapy, Springer-Verlag, Heidelberg, p. 555, 1966.
Fair, W. R., and Stamey, T. A. Differential renal function studies in segmental renal ischemia. J.A.M.A. 217: 790, 1971.
Fair,W. R. Difficulties in the evaluation of hypertension secondary to renal ischemia. Urol. Internat. 25:353, 1970.
Stamey, T. A., and Pfau, A. Some functional, pathological, bacteriological, and chemotherapeutic characteristics of unilateral pyelonephritis in man (Part I). Invest. Urol. 1: 134, 1963.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1972 Plenum Press, New York
About this chapter
Cite this chapter
Stamey, T.A. (1972). Measurement of Renal Vein Renins or Differential Renal Function Studies in the Diagnosis of Curable, Renovascular Hypertension?. In: Urological Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1941-2_16
Download citation
DOI: https://doi.org/10.1007/978-1-4684-1941-2_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-1943-6
Online ISBN: 978-1-4684-1941-2
eBook Packages: Springer Book Archive