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Renin and Erythropoietin Levels in Uremic and Anephric Man

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Urological Research

Abstract

The association of uremic renal disease with hypertension and anemia has been clinically identifiable for some time. The kidney is known to play a significant role in the production or release, or both, of two substances: erythropoietin (ESF), a hormone active in regulating the production of red blood cells(1), and renal renin(2). Levels of both of these hormones, ESF and renal renin, may be altered significantly in the presence of uremic renal insuficiency(2–4).

This study was supported in part by USPHS Grant CA-07745 and the J. A. Hartford Foundation, Inc.

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References

  1. Gordon, A. S. Hemopoietin. Physiol. Rev. 39: 1–40, 1959.

    PubMed  CAS  Google Scholar 

  2. Wilkinson, R., Scott, D. F., Uldall, P. R., Kerr, D. N. S., and Swinney, J. Plasma renin and exchangeable sodium in the hypertension of chronic renal failure. Quart. J. Med. 39: 377–394, 1970.

    PubMed  CAS  Google Scholar 

  3. Murphy, G. P., Mirand, E. A., and Kenny, G. M. Erythropoietin alterations in uremia renoprival states and after renal allograft. Urol. Digest 9: 24–32, 1970.

    Google Scholar 

  4. Mirand, E. A., and Murphy, G. P. Erythropoietin alterations in patients with uremia renal allografts, or without kidneys. J.A.M.A. 209: 392–398, 1969.

    Article  PubMed  CAS  Google Scholar 

  5. Gunnells, J. C., Grim, C. E., Robinson, R. R., and Wilderman, B. S. Plasma renin activity in healthy subjects and patients with hypertension. Arch. Int. Med. 119: 232, 1967.

    Article  CAS  Google Scholar 

  6. Weintraub, A. H., Gordon, A. S., Becker, E. L., Camiscoli, J. F., and Contrera, J. F. Am. J. Physiol. 207: 523, 1964.

    PubMed  CAS  Google Scholar 

  7. Fisher, J. W., Hatch, F. E., Roh, B. L., Allen, R. C., and Kelly, B. J. Erythropoietin inhibitor in kidney extracts and plasma from anemic uremic human subjects. Blood 31: 440, 1968.

    PubMed  CAS  Google Scholar 

  8. Mirand, E. A., Murphy, G. P., Steeves, R. A., Groenewald, J. H., and DeKlerk, J. N. Erythropoietin activity in anephric allotransplanted unilaterally nephrectomized and intact man. J. Lab. Clin. Med. 73: 121–128, 1969.

    PubMed  CAS  Google Scholar 

  9. Hampres, C. L., Skillman, J. J., Lyons, J. M., Olsen, J. E., and Merrill, J. P. Circulation 35: 272, 1967.

    Google Scholar 

  10. Hegstrom, R. M., Murray, J. S., Pendras, J. P., Burnell, J. M., and Scribner, B. M. Trans. Am. Soc. Artif. Int. Organs 8: 266, 1962.

    Article  CAS  Google Scholar 

  11. Onesti, G., Swartz, G., Ramirez, O., and Breast, A. N. Trans Am. Soc. Artif Int. Organs 14: 361, 1968.

    CAS  Google Scholar 

  12. Vertes, V., Cangiano, M. D., Berman, L. B., and Gould, A. New Engl. J. Med. 281: 272, 1969.

    Google Scholar 

  13. Toussaint, C. New Engl. J. Med. 281: 272, 1969.

    PubMed  CAS  Google Scholar 

  14. Smolev, J. K., Baer, D. M., and Murphy, G. P. Renin release and utilization by the isolated canine kidney. J. Urol. 106: 163, 1971.

    PubMed  CAS  Google Scholar 

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© 1972 Plenum Press, New York

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Murphy, G.P., Mirand, E.A. (1972). Renin and Erythropoietin Levels in Uremic and Anephric Man. In: Urological Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1941-2_15

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  • DOI: https://doi.org/10.1007/978-1-4684-1941-2_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1943-6

  • Online ISBN: 978-1-4684-1941-2

  • eBook Packages: Springer Book Archive

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