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The Structure of Antibodies

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Biochemistry of Antibodies

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Abstract

Considerable difficulties are involved in the study of immunoglobulins. Data on N-terminal amino acids, which have been useful for an understanding of the structure of many proteins, have not been of any essential help here. As mentioned earlier (cf. Chapter III), only one N-terminal amino acid — alanine (one mole alanine per mole protein) —plus a small quantity of aspartic acid and serine, has been found in rabbit γG-globulins. Three to five N-terminal amino acids have been found in equine and bovine γ-globulins, but their sum was less than one mole per mole protein. The γ-globulins of pigs and man contain two principal N-terminal amino acids. After reduction or denaturation, no new N-terminal amino acid residues appear. Hence, a reliable evaluation of the number of peptide chains in the immunoglobulin molecule cannot be obtained from these investigations.

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  1. Institute of Molecular Biology, Academy of Sciences of the USSR, Moscow, Russia

    Roal’d S. Nezlin

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© 1970 Plenum Press, New York

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Nezlin, R.S. (1970). The Structure of Antibodies. In: Biochemistry of Antibodies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1791-3_4

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  • DOI: https://doi.org/10.1007/978-1-4684-1791-3_4

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