Abstract
The nature of this morning’s meeting on blood and vascular changes resulting from contraceptive medication differs sharply from those previously held. Earlier we have considered significant biochemical changes resulting from contraceptive medication, changes which, in the main, appeared reversible or potentially reversible on discontinuation of medication and which were, generally speaking, clinically asymptomatic.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Inman, W.H. and Vessey, M.P.: Investigation of deaths from pulmonary, coronary and cerebral thrombosis and embolism in women of childbearing age. Brit. Med. J. 2:193 (1968).
Vessey, M.P. and Doll, R.: Investigation of relation between use of oral contraceptives and thromboembolic disease. Brit. Med. J. 2:199 (1968).
Drill, V.A. and Calhoun, D.W.: Oral contraceptives and thromboembolic disease. J.A.M.A. 206:77 (1968).
The Veterans Administration Co-operative Urological Research Group. Treatment and survival of patients with cancer of the prostrate. Surg. Obstet. Gyn. 124: 1011 (1967).
Oliver, M.F. and Boyd, G.S.: Influence of reduction of serum lipids on prognosis of coronary heart-disease. A five year study using oestrogen. Lancet ii:499 (1961).
Stamler, J., Pick, B., Katz, L.N., Pick, A., Berkson, D.M. and Century, D.: Effectiveness of oestrogens for therapy of myocardial infarction in middle-aged men. J. Am. Med. Assoc. 183: 632 (1963).
Daniel, D.G., Campbell, H. and Tumball, A.C.: Puerperal thromboembolism and suppression of lactation. Lancet ii:287 (1967).
Jeffcoate, T.N.A., Miller, J., Roos, R.F. and Tindall, V.B.:Puerpal thromboembolism in relation to the inhibition of lactation by oestrogen therapy. Brit. Med. J. 4:19 (1968).
Mustard, J.F., Roswell, H.C. and Murphy, E.A.: Thrombosis. Amer. J. Med. Sci. 248:469 (1964).
Mustard, J.F. and Packman, M.A.: The biochemistry of primary hemostasis. Page 306 in Plenary Session Papers XII. Congress International Society of Hematology, New York, (1968).
Mitchell, J. R. A.: The pathogenesis of thrombosis. Page 321 in Plenary Session Papers XII. Congress International Society of Hematology, New York (1968).12.
Esnouf, M.P.: Biochemical aspects of blood coagulation. Page 315 in Plenary Session Papers XII. Congress International Society of Hematology, New York (1968).
Crumb, J.D, and Ratnoff, O.D.: Activation of Hageman factor by solutions of ellagic acid. J. Lab. Clin. Med. 62:1006 (1963).
Sise, H.: Anovulatory hormones and blood coagulation. In Blood Coagulation, Thrombosis and Female Hormones. Editors: T. Astrup and I.S. Wright, James F. Mitchell Foundation, Washington, D.C., 1968, p. 19.
Owen, C.A., Thompson, J.H., Jr., Bowie, W., Didisheim, P. and Spittell, J.A.: Coagulation studies during pregnancy and hormone treatment. In Blood Coagulation, Thrombosis and Female Hormones. Editors: T. Astrup and I.S. Wright. James F. Mitchell Foundation, Washington, D.C., 1968, p. 24.
Poller, L., Tabiowa, A. and Thompson, J.M.: Effects of low-dose oral contraceptives on blood coagulation. Brit. Med. J. 2:218 (1968).
Gormsen, J., Fletcher, A.P., Alkjaersig, N. and Sherry, S.: Enzymatic lysis of plasma clots: the influence of fibrin stabilization on lysis rates. Archives of Biochem. and Biophys. 120:654 (1967).
Coopland, A., Fletcher, A.P. and Alkjaersig, N.: Reduction of plasma factor XIII (fibrin stabilizing factor) concentration during pregnancy. J. Lab. Clin. Med. (In Press).
Fletcher, A.P.: The problem of intravascular fibrinolytic reaction. In Platelets: Their Role in Hemostasis and Thrombosis. Editors: K.M. Brinkhous, I.S. Wright, J.P. Samlier, H.R. Roberts and S. Hinnon. Thromb. et diath. Haemorrh. Suppl. 26:343 (1967).
Fletcher, A.P. and Alkjaersig, N.: Plasma fibrinogen and hemostatic function (pathological and genetic disorders) Progress in Hematology (Editors: E.B. Brown and C.V. Moore), 5:246 (1966).
Allison, A.C. and Humphrey, J.H.: A theoretical and experimental analysis of double diffusion precipitin reaction in gels and its application characterization of antigens. Immunology 3:95 (1960).
Alkjaersig, N., Fletcher, A.P. and Bachmann, F.: In Preparation.
Scheraga, H.A. and Laskowski, M., Jr.: The fibrinogen- fibrin conversion. Advances in Protein Chemistry 12: 1(1957).
Alkjaersig, N., Fletcher, A.P. and Sherry, S.: The mechanism of clot dissolution by plasmin. J. Clin. Invest. 38: 1086 (1959).
Fletcher, A.P., Alkjaersig, N. and Sherry, S.: Fibrinolytic mechanisms and the development of thrombolytic therapy. Am. J. Med. 33:738 (1962).
Fletcher, A.P.: Measurement of plasma thrombolytic activity:isotopic method. In Blood Coagulation, Hemorrhage and Thrombosis:Methods of Study. Editors: L.A. Kazal and L.M. Tocantins. Grune and Stratton, 1964, p. 254.
Sawyer, W.D., Fletcher, A.P., Alkjaersig, N. and Sherry, S.: Studies on the thrombolytic activity of human plasma. J. Clin. Invest. 39:426 (1960).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1969 Plenum Press, New York
About this chapter
Cite this chapter
Fletcher, A.P., Alkjaersig, N. (1969). Thromboembolism and Contraceptive Medication: Incidence and Mechanism. In: Salhanick, H.A., Kipnis, D.M., Wiele, R.L.V. (eds) Metabolic Effects of Gonadal Hormones and Contraceptive Steroids. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1782-1_41
Download citation
DOI: https://doi.org/10.1007/978-1-4684-1782-1_41
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-1784-5
Online ISBN: 978-1-4684-1782-1
eBook Packages: Springer Book Archive