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Metabolic Effects of Gonadal Hormones and Contraceptive Steroids pp 232–241Cite as

Studies on the Mechanism of Hypertriglyceridemia Induced by Oral Contraceptives

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Abstract

We have heard convincing evidence this morning of the alterations in plasma lipids induced by a broad range of oral contraceptive preparations. Because of the epidemiological association between atherosclerotic cardiovascular disease and hyperlipoproteinemia, hypertriglyceridemia as well as hypercholesterolemia (1), and the possibility that progestational agents may therefore limit the relative immunity from atherosclerosis enjoyed by premenopausal women, we have begun to explore the mechanism of the hypertriglyceridemia of oral contraceptive therapy. These studies, then, evaluate the altered balance between triglyceride (TG) input and removal which result in a raised plasma TG concentration in women given oral progestational agents.

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Author information

Authors and Affiliations

  1. Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA

    W. R. Hazzard, M. J. Spiger & E. L. Bierman

Authors
  1. W. R. Hazzard
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  2. M. J. Spiger
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  3. E. L. Bierman
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Editor information

Editors and Affiliations

  1. Harvard Medical School, USA

    Hilton A. Salhanick (Professor of Obstetrics and Gynecology, Member) (Professor of Obstetrics and Gynecology, Member)

  2. Center for Population Studies, Harvard School of Public Health, USA

    Hilton A. Salhanick (Professor of Obstetrics and Gynecology, Member) (Professor of Obstetrics and Gynecology, Member)

  3. Washington University School of Medicine, USA

    David M. Kipnis (Professor of Medicine) (Professor of Medicine)

  4. College of Physicians and Surgeons, Columbia University, USA

    Raymond L. Vande Wiele (Professor of Obstetrics and Gynecology) (Professor of Obstetrics and Gynecology)

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© 1969 Plenum Press, New York

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Hazzard, W.R., Spiger, M.J., Bierman, E.L. (1969). Studies on the Mechanism of Hypertriglyceridemia Induced by Oral Contraceptives. In: Salhanick, H.A., Kipnis, D.M., Wiele, R.L.V. (eds) Metabolic Effects of Gonadal Hormones and Contraceptive Steroids. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1782-1_17

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  • DOI: https://doi.org/10.1007/978-1-4684-1782-1_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1784-5

  • Online ISBN: 978-1-4684-1782-1

  • eBook Packages: Springer Book Archive

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