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Photomedicine

Chapter

Abstract

The medical aspects of the science of photobiology are among the most important parts of this discipline, since they are concerned primarily with direct effects of nonionizing radiation on humans. Two organ systems are directly affected by sunlight: the eye and the skin. The eye is discussed in Chapter 10; this chapter will examine primarily cutaneous reactions to the sun.(1–4)

Keywords

Skin Cancer Stratum Corneum Action Spectrum Xeroderma Pigmentosum Unconjugated Bilirubin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    B. E. Johnson, F. Daniels, Jr., and I. A. Magnus, Response of human skin to ultraviolet light, Photophysiology 4, 139–202 (1968).Google Scholar
  2. 2.
    M. A. Pathak and J. H. Epstein, Normal and abnormal reactions of man to light, in: Dermatology in General Medicine (T. B. Fitzpatrick, K. A. Arndt, W. H. Clark, A. Z. Eisen, E. J. Van Scott, and J. H. Vaughan, eds.) pp. 977–1036, McGraw-Hill, New York (1971).Google Scholar
  3. 3.
    F. Urbach (ed.), The Biologic Effects of Ultraviolet Radiation ,Pergamon, New York (1969).Google Scholar
  4. 4.
    T. B. Fitzpatrick, M. A. Pathak, L. C. Harber, M. Seiji, and A. Kukita (eds.), Sunlight and Man ,University of Tokyo Press, Tokyo (1974).Google Scholar
  5. 5.
    I. Willis, A. Kligman, and J. H. Epstein, Effects of long ultraviolet rays on human skin: Photoprotective or photoaugmentative?, J. Invest. Dermatol. 59, 416–420 (1972).CrossRefGoogle Scholar
  6. 6.
    J. H. Epstein, K. Fukuyama, and K. Fye, Effects of ultraviolet radiation on the mitotic cycle and 1. DNA, RNA and protein synthesis in mammalian epidermis in vivo, Photochem. Photobiol. 12, 57–65(1970).Google Scholar
  7. 7.
    J. H. Epstein, Adverse cutaneous reactions to the sun, in: Yearbook of Dermatology (F. D. Malkinson and R. W. Pearson, eds.), pp. 5–43, Yearbook Medical Publ., Chicago, III. (1971).Google Scholar
  8. 8.
    D. S. Snyder and W. H. Eaglstein, Intradermal antiprostaglandin agents and sunburn, J. Invest. Dermatol. 62,47–50(1974).CrossRefGoogle Scholar
  9. 9.
    G. F. Wilgram, R. L. Kidd, W. S. Krawczyk, and P. L. Cole, Sunburn effect on keratinosomes, Arch. Dermatol. 101, 505–519(1970).CrossRefGoogle Scholar
  10. 10.
    K. Wier, K. Fukuyama, and W. L. Epstein, Nuclear changes during light-induced depression of ribonucleic acid and protein synthesis in human epidermis, Lab. Invest. 25, 451–456 (1971).Google Scholar
  11. 11.
    K. Fukuyama, W. L. Epstein, and J. H. Epstein, The effect of ultraviolet light on RNA and protein synthesis in differentiated epidermal cells, Nature 216, 1031–1032 (1967).CrossRefGoogle Scholar
  12. 12.
    G. A. Soffen and H. F. Blum, Quantitative measurements in changes in mouse skin following a single dose of ultraviolet light, J. Cell Comp. Physiol. 58, 81–96 (1961).CrossRefGoogle Scholar
  13. 13.
    W. S. Bullough and E. B. Laurence, Tissue homeostasis in adult mammals, in: Advances in Biology of Skin ,Vol. 7, Carcinogenesis (W. Montagna and R. L. Dobson, eds.), pp. 1–36, Pergamon, Oxford (1966).Google Scholar
  14. 14.
    J. J. Voorhees, E. A. Duell, and W. H. Kelsey, Dibutyryl cyclic AMP inhibition of epidermal cell division, Arch. Dermatol. 105, 384–386(1972).CrossRefGoogle Scholar
  15. 15.
    J. E. Cleaver, Repair of damaged DNA in human and other eukaryotic cells, in: Nucleic Acid-Protein Interactions-Nucleic Acid Synthesis in Viral Infection (D. W. Ribbons, J. F. Woessner, and J. Schultz, eds.), pp. 87–112, North-Holland, Amsterdam (1971).Google Scholar
  16. 16.
    J. E. Cleaver, Repair processes for photochemical damage in mammalian cells, Adv. Radiat. Biol. 4, 1–75(1974).Google Scholar
  17. 17.
    J. E. Cleaver and D. Bootsma, Xeroderma pigmentosum: Biochemical and genetic characteristics, Annu. Rev. Genet. 9, 19–38 (1975).CrossRefGoogle Scholar
  18. 18.
    A. R. Lehman, S. Kirk-Bell, C. F. Arlett, M. C. Paterson, P. H. M. Lohman, E. A. de Weerd-Kastelein, and D. Bootsma, Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation, Proc. Natl. Acad. Sci. USA 72, 219–223 (1975).CrossRefGoogle Scholar
  19. 19.
    R. L. Olson, J. Nordquist, and M. A. Everett, The role of epidermal lysosomes in melanin pigmentation, Br. J. Dermatol. 83, 189–199(1970).CrossRefGoogle Scholar
  20. 20.
    J. H. Epstein, K. Fukuyama, and R. L. Dobson, Ultraviolet light carcinogenesis, in: The Biologic Effects of Ultraviolet Radiation (F. Urbach, ed.), pp. 551–568, Pergamon, New York (1969).Google Scholar
  21. 21.
    W. L. Epstein, K. Fukuyama, and J. H. Epstein, Early effects of ultraviolet light on DNA synthesis in human skin in vivo, Arch. Dermatol. 100, 84–89 (1969).CrossRefGoogle Scholar
  22. 22.
    H. F. Blum, Carcinogenesis By Ultraviolet Light ,Princeton University Press, Princeton, N.J. (1959).Google Scholar
  23. 23.
    J. H. Epstein, Ultraviolet carcinogenesis, Photophysiology 5, 235–273 (1970).Google Scholar
  24. 24.
    V. M. Maher, L. M. Oullette, R. D. Curren, and J. J. McCormick, Frequency of ultraviolet light-induced mutations is higher in xeroderma pigmentosum variant cells than in normal human cells, Nature 261, 593–595 (1976).CrossRefGoogle Scholar
  25. 25.
    J. H. Epstein, Photoallergy: A review, Arch. Dermatol. 106, 741–748 (1972).CrossRefGoogle Scholar
  26. 26.
    H. F. DeLuca, Vitamin D: The vitamin and the hormone, Fed. Proc. 33, 2211–2219 (1974).Google Scholar
  27. 27.
    W. F. Loomis, Skin-pigmentation regulation of vitamin D biosynthesis in man, Science 157, 501–506(1967).CrossRefGoogle Scholar
  28. 28.
    K. H. Kaidbey and A. M. Kligman, Photopigmentation with trioxsalan, Arch. Dermatol. 109, 674–677(1974).CrossRefGoogle Scholar
  29. 29.
    J. A. Parrish, T. B. Fitzpatrick, L. Tanenbaum, and M. A. Pathak, Photochemotherapy of psoriasis with oral methoxsalen and long-wave ultraviolet light, N. Engl. J. Med. 291, 1207–1211 (1974).CrossRefGoogle Scholar
  30. 30.
    L. E. Bockstahler, C. D. Lytle, and K. B. Hellman, A Review of Photodynamic Therapy for Herpes Simplex: Benefits and Potential Risks ,DHEW Publication No. (FDA) 75–8013. (Available from the Bureau of Radiological Health, Rockville, MD 20852.) (1974).Google Scholar
  31. 31.
    Phototherapy in the Newborn ,Final report of the Committee, Division of Medical Sciences, National Research Council (2101 Constitution Ave.) Washington D.C., 20418 (1974).Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  1. 1.Department of DermatologyUniversity of California, School of MedicineSan FranciscoUSA

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