Abstract
The detrimental effects of ultraviolet (UV) radiation are well documented, and appear to be mediated largely through its action upon deoxyribonucleic acid (DNA). The most detrimental effect, of course, is cell killing. Other effects include mutagenesis, carcinogenesis, interference with the synthesis of DNA, ribonucleic acid (RNA), and protein, delay of cell division, and changes in permeability and motility. Except for the production of vitamin D in the skin of man, the beneficial effects of UV radiation are not as well documented (see Section 7.6.).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
K. C. Smith and P. C. Hanawalt. Molecular Photobiology (Inactivation and Recovery), Academic Press. New York (1969).
J. Jagger, Introduction to Research in Ultraviolet Photobiology ,Prentice-Hall, Englewood Cliffs, N.J. (1967).
A. C. Giese, Living With Our Sun’s Ultraviolet Rays ,Plenum Press, New York (1976).
S. Y. Wang (ed.), Photochemistry and Photobiology of Nucleic Acids ,Academic Press, New York (1976).
A. J. Varghese, Photochemistry of nucleic acids and their constituents, Photophysiology 7, 207–274 (1972).
R. O. Rahn, Ultraviolet irradiation of DNA, in: Concepts in Radiation Cell Biology (G. L. Whitson, ed.), pp. 1–56, Academic Press, New York (1972).
K. C. Smith (ed.). Aging, Carcinogenesis and Radiation Biology (The Role of Nucleic Acid Addition Reactions), Plenum Press, New York (1976).
A. D. McLaren and D. Shugar, Photochemistry of Proteins and Nucleic Acids ,Pergamon Press. Oxford (1964).
F. Hutchinson, The lesions produced by ultraviolet light in DNA containing 5-bromouracil, Q. Rev. Biophys. 6, 201–246 (1973).
R. O. Rahn, L. C. Landry, and W. L. Carrier, Formation of chain breaks and thymine dimers in DNA upon photosensitization at 313 nm with acetophenone. acetone or benzophenone. Photochem. Photobiol. 19, 75–78 (1974).
D. Lenov, J. Salomon, and D. Elad, Ultraviolet-and ;-ray-induced reactions of nucleic acid constituents with alcohols. On the selectivity of the reactions for purines, Photochem. Photobiol. 17,465–468(1973).
G. R. Banks, D. M. Brown, D. G. Streeter, and L. Grossman, Mutagenic analogues of cytosine: RNA polymerase template and substrate studies, J. Mol. Biol. 60, 425–439 (1971).
Yu. A. Vladimirov, D. I. Roschupkin, and E. E. Fesenko, Photochemical reactions of amino acid residues and inactivation of enzymes during UV-irradiation. A review, Photochem. Photobiol. 11, 227–246 (1970).
L. I. Grossweiner, Photochemical inactivation of enzymes, Curr. Top Radiat. Res. 11, 141–199 (1976).
A. D. McLaren and O. Hidalgo-Salvatierra, Quantum yields for enzyme inactivation and the amino acid composition of proteins, Photochem. Photobiol. 3, 349–352 (1964).
L. Augenstein and P. Riley, The inactivation of enzymes by ultraviolet light. IV. The nature and involvement of cystine disruption, Photochem. Photobiol. 3, 353–367 (1964); see also, ibid. 6, 423–436 (1967).
P. C. Hanawalt and R. B. Setlow (eds.), Molecular Mechanisms For Repair Of DNA ,Plenum Press, New York (1975).
R. B. Roberts and E. Aldous, Recovery from ultraviolet irradiation in Escherichia coli, J. Bacteriol. 57, 363–375 (1949).
K. C. Smith, The roles of genetic recombination and DNA polymerase in the repair of damaged DNA, Photophysiology 6, 209–278 (1971).
P. A. Swenson, Physiological responses of Escherichia coli to far-ultraviolet radiation, in: Photochemical and Photobiological Reviews (K. C. Smith, ed.), Vol. 1, pp. 269–387, Plenum Press, New York (1976).
D. E. Lea, Actions of Radiation on Living Cells ,Cambridge University Press, London (1955) (Reprinted 1962).
R. H. Haynes, The influence of repair processes on radiobiological survival curves, in: Cell Survival After Low Doses of Radiation: Theoretical and Clinical Implications (T. Alper, ed.), pp. 197–208 Wiley, New York (1975).
W. Harm, C. S. Rupert, and H. Harm, The study of photoenzymatic repair of UV lesions in DNA by flash photolysis, Photophysiology 6, 279–324 (1971).
E. C. Friedberg, K. H. Cook, J. Duncan, and K. Mortelmans, DNA repair enzymes in mammalian cells, in: Photochemical and Photobiological Reviews (K. C. Smith, ed.), Vol. 2, pp. 263–322, Plenum Press, New York (1977).
P. Howard-Flanders, DNA repair, Annu. Rev. Biochem. 37, 175–200 (1968).
R. B. Setlow and J. K. Setlow, Effects of radiation on polynucleotides, Annu. Rev. Biophys. Bioeng. 1, 293–346 (1972).
L. Grossman, Enzymes involved in the repair of DNA, Adv. Radiat. Biol. 4, 77–129 (1974).
C. D. Town, K. C. Smith, and H. S. Kaplan, Repair of X-ray damage to bacterial DNA, Curr. Top. Radiat. Res. 8, 351–399 (1973).
J. E. Cleaver, Repair processes for photochemical damage in mammalian cells, Adv. Radiat. Biol. 4, 1–75 (1974).
E. Witkin, Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli, Bacteriol. Rev. 40, 869–907 (1976).
B. A. Bridges, Mechanisms of radiation mutagenesis in cellular and subcellular systems, Annu. Rev. Nuclear Sci. 19, 139–177 (1969).
C. O. Doudney, Ultraviolet light effects on the bacterial cell, Curr. Top. Microbiol. Immunol. 46, 116–175(1968).
J. D. Watson, Molecular Biology of the Gene (3rd ed.), Benjamin, New York (1976).
W. Hayes, The Genetics of Bacteria and their Viruses (2nd ed.), Wiley, New York (1968).
K. C. Smith, Ultraviolet radiation-induced mutability of uvrD3 strains of Escherichia coli B/r and K-12: A problem in analyzing mutagenesis data, Photochem. Photobiol. 24, 433–437 (1976).
J. McCann and B. N. Ames, Detection of carcinogens as mutagens in the Salmonella/microsome ,test: Assay of 300 chemicals: Discussion, Proc. Natl. Acad. Sci. USA 73, 950–954 (1976).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1977 Plenum Press, New York
About this chapter
Cite this chapter
Smith, K.C. (1977). Ultraviolet Radiation Effects on Molecules and Cells. In: Smith, K.C. (eds) The Science of Photobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1713-5_5
Download citation
DOI: https://doi.org/10.1007/978-1-4684-1713-5_5
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-1715-9
Online ISBN: 978-1-4684-1713-5
eBook Packages: Springer Book Archive