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Signal Transduction by G Protein-Coupled Receptors pp 17–26Cite as

Primary and Secondary Proton Pumps

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Abstract

Primary pups differ highly depending upon the energy source used by the membrane. For example, the respiratory chains of mammalian mitochondria act as oxidation-reduction driven proton pumps, which transfer electrons from the NAD+/NADH couple to the O2/H2O couple. The respiratory chain consists of more than 20 discrete carriers of electrons which are mainly grouped into four polypeptide complexes: NADH-ubiquinone oxidoreductase, succinate dehydrogenase, ubiquinol-cytochrome c oxido-reductase and cytochrome c oxidase. Three of these complexes are involved in proton translocation.

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Authors and Affiliations

  1. Leiden/Amsterdam Center for Drug Research, Amsterdam, The Netherlands

    Paul H. J. Nederkoorn Ph.D., Henk Timmerman Ph.D. & Gabriëlle M. Donné-Op den Kelder Ph.D.

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  1. Paul H. J. Nederkoorn Ph.D.
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  2. Henk Timmerman Ph.D.
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  3. Gabriëlle M. Donné-Op den Kelder Ph.D.
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© 1997 Springer Science+Business Media Dordrecht

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Nederkoorn, P.H.J., Timmerman, H., den Kelder, G.M.DO. (1997). Primary and Secondary Proton Pumps. In: Signal Transduction by G Protein-Coupled Receptors. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1407-3_2

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  • DOI: https://doi.org/10.1007/978-1-4684-1407-3_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1409-7

  • Online ISBN: 978-1-4684-1407-3

  • eBook Packages: Springer Book Archive

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