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Ragab, A., Frech, R., and Vietti, T. Osteoporotic fractures secondary to methotrexate therapy of acute leukemia in remission. Cancer 25: 580, 1970.
Bertino, J. The mechanism of action of the folate antagonists in man. Cancer Res 23: 1286, 1963.
Werkheiser, W. The biochemical, cellular, and pharmacological action and effects of the folic acid antagonists. Cancer Res 23: 1277, 1963.
Wells, W., and Winzler, R. Metabolism of humman leukocytes in vitro. III. Incorporation of formate-C into cellular components of leukemic human leukocytes. Cancer Res 19: 1086, 1959.
Winzler, R., Williams, A., and Best, W. Metabolism of human leukocytes in vitro. I. Effects of a-methopterin on formate-C14 incorporation. Cancer Res 17: 108, 1957.
Roberts, D., and Wodinsky, I. On the poor correlation between the inhibition by methotrexate of dihydrofolate reductase and of deoxynucleoside incorporation into DNA. Cancer Res 28: 1955, 1968.
Fischer, G. Increased levels of folic acid reductase as a mechanism of resistance to amethopterin in leukemic cells. Biochem Pharmacol 7: 75, 1961.
Hakala, M., Lakrzewski, S., and Nichol, C. Relation of folic acid reductase to amethopterin resistance in cultured mammalian cells. J Biol Chem 236: 952, 1961.
Hakala, M. On the role of drug penetration in amethopterin resistance of sarcoma-180 cells in vitro. Biochim Biophys Acta 102: 198, 1965.
Kessel, D., Hall, T., Roberts, D., et al. Uptake as a determinant of methotrexate response in mouse leukemias. Science 150: 752, 1965.
Goldin, A., Venditti, J., Humphreys, S., et al. Modification of treatment schedules in the management of advanced mouse leukemia with amethopterin. J Nat Cancer Inst 17: 203, 1956.
Dameshek, W. The use of folic acid antagonists in the treatment of acute and subacute leukemia. Blood 4: 168, 1949.
Sacks, M., Bradford, G., and Schoenbach, E. The response of acute leukemia to the administration of the folic acid antagonists, aminopterin and a-methopterin: report of 14 cases. Ann Intern Med 32: 80, 1950.
Dameshek, W., Freedman, M., and Steinberg, L. Folic acid antagonists in the treatment of acute and subacute leukemia. Blood 5: 898, 1950.
Burchenal, J., Karnofsky, D., Kingsley-Pillers, E., et al. The effects of the folic acid antagonists and 2, 6diaminopurine on neoplastic disease. Cancer 4: 549, 1951.
Schoenbach, E., Colsky, J., and Greenspan, E. Observations on the effects of the folic acid antagonists, aminopterin and amethopterin, in patients with advanced neoplasms. Cancer 5: 1201, 1952.
Frei, E., Holland, J., Schneiderman, M., et al. A comparative study of two regimens of combination chemotherapy in acute leukemia. Blood 13: 1126, 1958.
Whiteside, J., Philips, F., Dargeon, H., and Burchenal, J. Intrathecal amethopterin in neurological manifestations of leukemia. Arch Intern Med 101: 279, 1958.
Wright, J., Cobb, J., Golomb, F., Gumport, S., Lyall, D., and Safadi, D. Chemotherapy of disseminated carcinoma of the breast. Ann Surg 150: 221, 1959.
Murphy, M. Leukemia and lymphoma in children. Pediat Clin N Amer 6: 611, 1959.
Wright, J., Gumport, S., and Golomb, F. Remissions produced with the use of methotrexate in patients with mycosis fungoides. Cancer Chemother Rep 9: 11, 1960.
Condit, P., and Eliel, L. Effects of large infrequent doses of a-methopterin on acute leukemia in children. JAMA 172: 451, 1960.
Sullivan, R., Miller, E., Wood, A., Clifford, P., Duff, J., Trussell, R., and Burchenal, J. Continuous infusion cancer chemotherapy in humans-effects of therapy with intra-arterial methotrexate plus intermittent intramuscular citrovorum factor. Cancer Chemother Rep 10: 39, 1960.
Sullivan, R., Wood, A., Clifford, P., Duff, J., Trussell, R., Nary, D., and Burchenal, J. Continuous intra-arterial methotrexate with simultaneous, intermittent, intramuscular citrovorum factor therapy in carcinoma of the cervix. Cancer Chemother Rep 8: 1, 1960.
Laurance, B. Intracranial complications of leukemia treated with intrathecal amethopterin. Arch Dis Childh 36: 107, 1961.
Trussell, R., and Mitford-Barberton, G. Carcinoma of the cervix treated with continuous intra-arterial methotrexate and intermittent intramuscular leucovorin. Lancet 1: 971, 1961.
Hreshchyshyn, M., Graham, J., and Holland, J. Treatment of malignant trophoblastic growth in women, with special reference to amethopterin. Amer J Obstet Gyn 81: 688, 1961.
Cahill, J., and Zeit, P. Intra-arterial infusions of pelvic tumors with amethopterin. Amer J Obstet Gyn 81: 970, 1961.
Manahan, C., Benitez, I., and F. Amethopterin Estrella, the treatment of in Amer J Obstet trophoblastic tumors. 82: 641, 1961.
Hertz, R., Lewis, J., and Lipsett, M. Five years’ experience with the chemotherapy of metastatic choriocarcinoma and related trophoblastic tumors in women. Amer J Obstet Gyn 82: 631, 1961.
Shanbrom, E., Miller, S., and Fairbanks, V. Intrathecal administration of amethopterin in leukemic encephalopathy of young adults. New Eng J Med 265: 169, 1961.
Frei, E., et al. Studies of sequential and combination antimetabolite therapy in acute leukemia: 6-mercaptopurine and methotrexate. Blood 18: 431, 1961.
Greening, W. Methotrexate in the treatment of advanced cancer of the breast. In “Methotrexate in the Treatment of Cancer,” (Porter and Wiltshaw, eds.), pp 29–33, 1962.
Perese, D., Day, C., and Chardack, W. Chemotherapy of brain tumors by intra-arterial infusion. J Neurosurg 19: 215, 1962.
Balla, G., Mallams, J., Hutton, S., et al. The treatment of head and neck malignancies by continuous intra-arterial infusion of methotrexate. Amer J Surg 104: 699, 1962.
Condit, P., Shnider, B., and Owens, A. Studies on the folic acid vitamins VII. The effect of large doses of amethopterin in patients with cancer. Cancer Res 22: 706, 1962.
Perrin, J., and Mauer, A. Evaluation of intravenous amethopterin therapy in acute leukemia. J Pediat 61: 283, 1962.
Levick, S., Belmont, O., Cohen, E., and Steinmetz, C. Treatment of malignant melanoma of the orbit with intra-arterial methotrexate. JAMA 182: 300, 1962.
Elliot, J. Treatment of bladder cancer with amethopterin. Cancer Chemother Rep 20: 147, 1962.
Huseby, R., and Downing, V. The use of methotrexate orally in treatment of squamous cancers of the head and neck. Cancer Chemother Rep 16: 511, 1962.
Yollick, B., and Corgill, D. Regional chemotherapy of head and neck tumors by intra-arterial infusion techniques. Texas State J Med 59: 423, 1963.
Benson, J., Kiehn, C., and Holden, W. Cancer chemotherapy by arterial infusion. Arch Surg 87: 125, 1963.
Bagshawe, K. Trophoblastic tumors. Chemotherapy and developments. Brit Med J 5368: 1303, 1963.
Perrin, J., Mauer, A., and Sterling, T. Intravenous methotrexate (amethopterin) therapy in the treatment of acute leukemia. Pediatrics 31: 833, 1963.
Papac, R., Jacobs, E., Foye, L., and Donohue, D. Systemic therapy with amethopterin in squamous carcinoma of the head and neck. Cancer Chemother Rep 32: 47, 1963.
Hertz, R., Ross, G., and Lipsett, M. Primary chemotherapy of non-metastatic trophoblastic disease in women. Amer J Obstet Gyn 86: 808, 1963.
Bellman, S., Hugosson, R., Johansson, B., and Sjogren, S. Chemotherapy of five supratentorial malignant gliomas with intra-arterial infusion of methotrexate. Acta Chir Scand 127: 569, 1964.
Hreshchyshyn, M. Experience with chemotherapy in gynecologic cancer. New York State J Med 64: 2431, 1964.
Bagshawe, K., and Wilde, C. Infusion therapy for pelvic trophoblastic tumors. J Obstet Gynec Brit Comm 71: 565, 1964.
Acquarelli, M., Feder, R., and Gordon, H. Continuous intra-arterial infusion of methotrexate for recurrent squamous cell carcinoma of the head and neck. Amer Surg 30: 423, 1964.
Hayes, D., Wilkins, F., and Meredith, J. Regional arterial infusion for localized malignancies. Arch Surg 88: 1070, 1964.
Jesse, R., Villarreal, R., Letayf, V., et al. Intra-arterial infusion for head and neck cancer. Arch Surg 88: 618, 1964.
Hertz, R., Ross, G., and Lipsett, M. Chemotherapy in women with trophoblastic disease: choriocarcinoma, chorioadenoma destruens, and complicated hydatidiform mole. Ann N Y Acad Sci 114: 881, 1964.
Vogler, W.R., Huguley, C., Lea, J., et al. Treatment of acute leukemia in adults with repeated 5-day courses of methotrexate in multiple small oral doses. Proc Amer Assoc Cancer Res 5: 66, 1964.
Evans, A., D’Angio, G., and Mitus, A. Central nervous system complications of children with acute leukemia. J Pediat 64: 94, 1964.
Brewer, J., Gerbie, A., Dolkart, R., et al. Chemotherapy in trophoblastic diseases. Amer J Obstet Gyn 90: 566, 1964.
Lamb, E., Morton, D., and Byron, R. Methotrexate therapy of choriocarcinoma and allied tumors. Amer J Obstet Gyn 90: 317, 1964.
Condit, P., Ridings, G., Coin, J., et al. Methotrexate and radiation in the treatment of patients with cancer. Cancer Res 24: 1524, 1964.
Espiner, H., and Westbury, G. Continuous chemotherapy by intra-arterial infusion. Acta Un Int Cancr 20: 475, 1964.
Hellman, S., Zanotti, A., and Bertino, J. Determinations of the levels of serum folate in patients with carcinoma of the head and neck treated with methotrexate. Cancer Res 24: 105, 1964.
Watkins, E., and Sullivan, R. Cancer chemotherapy by prolonged arterial infusion. Surg Gyn and Obstet 118: 1, 1964.
Beahrs, O., Caldarola, V., and Harrison, E. Treatment of cancer of the head and neck by chemotherapy. JAMA 189: 163, 1964.
Frei, E., Speers, C., Brindley, C., et al. Clinical studies of dichloromethotrexate (NSC 29630). Clin Pharm Ther 6: 160, 1965.
Baker, R., and Gaertner, R. Regional arterial infusion of antimetabolites. J Surg Res 5: 132, 1965.
Wilson, H., and Louis, J. The use of low dosage drug regimens in the treatments of neoplastic disease. Ann Intern Med 63: 918, 1965.
Vogler, W., Huguley, C., and Kerr, W. Toxicity and antitumor effect of divided doses of methotrexate. Arch Intern Med 115: 285, 1965.
Ross, G., Goldstein, D., Hertz, R., et al. Sequential use of methotrexate and actinomycin D in the treatment of metastatic choriocarcinoma and related trophoblastic diseases in women. Amer J Obstet Gyn 93: 223, 1965.
Selawry, O. (Acute Leukemia Group B). New treatment schedule with improved survival in childhood leukemia. Intermittent parenteral vs daily oral administration of methotrexate for maintenance of induced remission. JAMA 194: 75, 1965.
Burkitt, D., Hutt, M., and Wright, D. The African lymphoma. Preliminary observations on response to therapy. Cancer 18: 399, 1965.
Hodgkinson, C., and Boyce, C. Prolonged intra-arterial therapy for advanced pelvic malignancy. Cancer 18: 1536, 1965.
Ross, C., and Selawry, O. Comparison of three dose schedules of methotrexate in lung cancer. Proc Amer Assoc Cancer Res 6: 54 (0214), 1965.
Burn, J., Johnston, I., Davies, A., and Sellwood, R. Cancer chemotherapy by continuous intra-arterial infusion of methotrexate. Brit J Surg 53: 329, 1966.
Selawry, O., and James, D. Therapeutic index of methotrexate as related to dose schedule and route of administration in children with acute lymphocytic leukemia. Proc Amer Assoc Cancer Res 6: 56 (#224), 1965.
Kligerman, M., Hellman, M., von Essen, C., and Bertino, J. Sequential chemotherapy and radiotherapy. Preliminary results of clinical trial with methotrexate in head and neck cancer. Radiology 86: 247, 1966.
Rubin, R., Ommaya, A., Henderson, E., Bering, E., and Rall, D. Cerebrospinal fluid perfusion for central nervous system neoplasms. Neurology 16: 680, 1966.
Luyendijk, W., and van Beusekom, G. Chemotherapy of cerebral gliomas with intra-carotid methotrexate-infusion. Acta Neurochir 15: 234, 1966.
Gorgun, B., and Watne, A. Infusion chemotherapy in head and neck tumors. Arch Surg 92: 951, 1966.
Dietzel, H., and Schwarz, R. Primary treatment of choriocarcinoma with methotrexate. Arch Surg 92: 301, 1966.
Krivit, W., Brubaker, C., Hartmann, J., et al. Induction of remission in acute leukemia of childhood by combination of prednisone and either 6-mercaptopurine or methotrexate. J Pediat 68: 965, 1966.
Laufe, L., Blockstein, R., Parsi, F., and Lowy, A. Infusion through inferior gluteal artery for pelvic cancer. Obstet Gyn 28: 650, 1966.
Bateman, J., Hazen, J., Stolinsky, D., and Steinfeld, J. Advanced carcinoma of the cervix treated by intra-arterial methotrexate. Amer J Obstet Gyn 96: 181, 1966.
Roy, D. Treatment of advanced or recurrent carcinoma of the cervix by cytotoxic drugs. Indian J Cancer 4: 32, 1967.
Hardisty, R., and Norman, P. Meningeal leukemia. Arch Dis Childh 42: 441, 1967.
Eastern Cooperative Group in Solid Tumor Chemotherapy. Comparison of antimetabolites in the treatment of breast and colon cancer. JAMA 200: 770, 1967.
Wei, P., and Ouyang, P. The use of methotrexate in the treatment of trophoblastic disease, especially choriocarcinoma. Amer J Obstet Gyn 98: 79, 1967.
Hammond, C., Hertz, R., Ross, G., et al. Primary chemotherapy for non-metastatic gestational trophoblastic neoplasms. Amer J Obstet Gyn 98: 71, 1967.
Vogler, W., Huguley, C., and Rundles, R. Comparison of methotrexate with 6-mercaptopurine-prednisone in treatment of acute leukemia in adults. Cancer 20: 1221, 1967.
Djerassi, I. Methotrexate infusions and intensive supportive care in the management of children with acute lymphocytic leukemia: follow-up report. Cancer Res 27: 2561, 1967.
Norrell, H., and Wilson, C. Brain tumor chemotherapy with methotrexate given intrathecally. JAMA 201: 15, 1967.
Sullivan, R., Miller, E., Zurek, W., Oberfield, R., and Ojima, Y. Re-evaluation of methotrexate as an anticancer drug. Surg Gyn and Obstet 125: 819, 1967.
Tindel, S. Intra-arterial chemotherapy for recurrent neoplasms. JAMA 200: 913, 1967.
Lefkowitz, E., Papac, R., and Bertino, J. Head and neck cancer. III. Toxicity of 24-hour infusions of methotrexate (NSC 740) and protection by leucovorin (NSC 3590) in patients with epidermoid carcinomas. Cancer Chemother Rep 51: 305, 1967.
Wyatt, J., and McAninch, L. A chemotherapeutic approach to advanced testicular carcinoma. Canad J Surg 10: 421, 1967.
Papac, R., Lefkowitz, E., and Bertino, J. Methotrexate (NSC 740) in squamous cell carcinoma of the head and neck. II. Intermittent intravenous therapy. Cancer Chemother Rep 51: 69, 1967.
Reed, L., Muggia, F., Klipstein, F., and Gellhorn, A. Intermittent parenteral methotrexate (NSC 740) therapy for carcinoma of the lung. Cancer Chemother Rep 51: 475, 1967.
Andrews, N., and Wilson, W. Phase II study of methotrexate in solid tumors. Cancer Chemother Rep 51: 471, 1967.
Johnson, F., Jacobs, E., and Silliphant, W. Trophoblastic tumors of the uterus. Problems of methotrexate therapy. Calif Med 108: 1, 1968.
Newton, W., Sayers, M., and Samuels, L. Intrathecal methotrexate (NSC 740) therapy for brain tumors in children. Cancer Chemother Rep 52: 257, 1968.
Brubaker, C., Gilchrist, G., Hammond, D., et al. Induction of remission in acute leukemia with prednisone and intravenous methotrexate. J Pediat 73: 623, 1968.
Couture, J. Intra-arterial infusion therapy for oral cancer. Canad J Surg 11: 420, 1968.
Lane, M., Moore, J., Levin, H., et al. Methotrexate therapy for squamous cell carcinomas of the head and neck. JAMA 204: 561, 1968.
Selawry, O., and Odom, S. On eradication of leukemic meningiopathy. Proc Amer Assoc Cancer Res 9: 62 (#246), 1968.
Nevinny, H., Hall, T., Haines, C., et al. Comparison of methotrexate (NSC 740) and testosterone propionate (NSC 9166) in the treatment of breast cancer. J Clin Pharm 8: 126, 1968.
Vogler, W., Furtado, V., and Huguley, C. Methotrexate for advanced cancer of the breast. Cancer 21: 26, 1968.
Leone, L., Albala, M., and Rege, V. Treatment of carcinoma of the head and neck with intravenous methotrexate. Cancer 21: 828, 1968.
Weiss, S., and Raskind, R. Treatment of malignant brain tumors by local methotrexate. A preliminary report. Int Surg 51: 149, 1969.
Hsu, C., and Cheng, Y. Methotrexate therapy in trophoblastic disease at the Provincial Taipei Hospital (1955–1966). A re-evaluation and proposals. Amer J Obstet Gyn 103: 60, 1969.
Wilson, C., and Norrell, H. Brain tumor chemotherapy with intrathecal methotrexate. Cancer 23: 1038, 1969.
Acute Leukemia Group B. Acute lymphocytic leukemia in children. Maintenance therapy with methotrexate administered intermittently. JAMA 207: 923, 1969.
Sullivan, M., Haggard, M., Donaldson, M., et al. Comparison of the prolongation of remission in meningeal leukemia with maintenance intrathecal methotrexate and intravenous bisnitrosourea (BCNU). Proc Amer Assoc Cancer Res 11: 77 (0306), 1970.
VA Lung Group, unpublished data. (Personal communication, Dr. Julius Wolf).
Goldin, A., Venditti, J., Kline, I., et al. Eradication of leukemic cells (L1210) by methotrexate and methotrexate plus citrovorum factor. Nature 212: 1548, 1966.
Selawry, O. Tolerance to sequential use of methotrexate and leukovorin in cancer patients. Proc Amer Assoc Cancer Res 11: 72 (#283), 1970.
Moertel, C., Reitemeier, R., and Hahn, R. Oral methotrexate therapy of gastrointestinal carcinoma. Surg Gyn Obstet 130: 292, 1970.
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Livingston, R.B., Carter, S.K. (1970). Methotrexate. In: Single Agents in Cancer Chemotherapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1378-6_7
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