Abstract
Investigation into the fibrogenic and possibly carcinogenic effects of asbestos fibres have been centred largely on the structural and aerodynamic properties of the fibres (Timbrell, 1973). However, other factors, particularly the body’s defences and altered immune competence, have also been linked with asbestos exposure. Epidemiological and immunological studies of asbestos workers have documented abnormalities in both humoral and cell-mediated immunity (Doll et al., 1983). Immune response to asbestos has been suggested as an important component in the pathophysiology of asbestosis (Pernis & Vigliani, 1982), however, the effect of asbestos inhalation on local or systemic immunity is not well understood. The majority of workers developing asbestosis have been exposed to high dust concentrations for a prolonged periods of time. There are, however, many workers who remain healthy in spite of the significant exposure to asbestos (Turner-Warwick, 1973). The aim of this study was to compare the immunological alterations that occur in an asbestos-exposed diseased group and in an asbestos-exposed non-diseased group.
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References
Doll, N.J., Stankus, R.P. and Barkman, H.W. (1983) Immunopathogenesis of Asbestosis, Silicosis, and Coal Workers’ Pneumoconiosis. Clinics in Chest Medicine 4: 3–14.
Holm, G., Pettersson, D., Mellstedt, H., Hedfors, E. and Bloth, B. (1975) Lymphocyte subpopulations in peripheral blood of healthy persons. Characterization by surface markers and lack of selection during purification. Clin. Exp. Immunol. 20: 443–457.
Pernis, B., Vigliani, E.C. (1982) The Role of Macrophages and Immunocytes in the Pathogenesis of Pulmonary Diseases Due to Mineral Dusts. Am. J. Indust. Med. 3: 133–137.
Timbrell, V. (1973) Physical factors as etiological mechanisms. Biological Effects of Asbestos - Proceedings of a Working Conference, held at the International Agency for Research on Cancer, Lyon, France, 2–6 Oct. 1972.
Turner-Warwick, M. (1973) Immunology and Asbestosis. Proc. Roy. Soc. Med. 66: 927–930.
Willemsen, E.W. (1974) Understanding Statistical Reasoning. Atkinson, R.C., Freedman, J. and Thompson. G.F., eds. Library of Congress Cataloging in Publication Data. San Francisco, (1974) pp. 168–196.
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© 1991 Plenum Press, New York
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Trosic, I., Saric, M., Pisl, Z., Stilinovic, L. (1991). Influence of Long-Lasting Asbestos Exposure on Immunological Status of Asbestos Exposed Shipyard Workers. In: Brown, R.C., Hoskins, J.A., Johnson, N.F. (eds) Mechanisms in Fibre Carcinogenesis. NATO ASI Series, vol 223. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1363-2_4
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DOI: https://doi.org/10.1007/978-1-4684-1363-2_4
Publisher Name: Springer, Boston, MA
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