Abstract
Promoters of carcinogenesis, are themselves neither mutagenic nor carcinogenic,one possible mechanism of their action is through enhanced cellular division and proliferation, processes necessary for neoplastic transformation. There is considerable evidence that asbestos, and other mineral fibres, have tumour promoting properties. Several in vivo experimental studies have demonstrated synergy between asbestos and a chemical carcinogen (e.g. Harrison & Heath, 1988) and this might indicate that asbestos may function as a tumour promoter. There is also epidemiological evidence for its tumour-promoting activities including the synergism between asbestos exposure and smoking in the aetiology of lung cancer in humans (NRC, 1984).
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© 1991 Plenum Press, New York
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Hoskins, J.A., Brown, R.C., Evans, C.E. (1991). Promoting Effects of Fibres. Fibres and the Second Messenger Pathways. In: Brown, R.C., Hoskins, J.A., Johnson, N.F. (eds) Mechanisms in Fibre Carcinogenesis. NATO ASI Series, vol 223. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1363-2_39
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DOI: https://doi.org/10.1007/978-1-4684-1363-2_39
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