Abstract
Asbestos-induced lipid peroxidation in different systems is well documented in the literature. Many reports note the detection of malondialdehyde as a measure of peroxidation of unsaturated fatty acids by the thiobarbituric acid (TBA) method. Although the TBA method is quite simple and easy to use, it has many limitations and therefore has to be cross-checked by reference to one or more other methods.
Electron spin resonance was employed to monitor the peroxidation of lipids in multilamellar liposomal suspensions in the presence of hydrogen peroxide and different asbestos fibres. A correlation could be found between the ability of these minerals to generate hydroxyl radical and the ability to support peroxidation of lipids in multilamellar liposomes. This correlation agreed well with the fibrogenicity and/or carcinogenicity of the fibres tested.
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© 1991 Plenum Press, New York
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Gulumian, M., van Wyk, J.A. (1991). Oxygen Consumption, Lipid Peroxidation and Mineral Fibres. In: Brown, R.C., Hoskins, J.A., Johnson, N.F. (eds) Mechanisms in Fibre Carcinogenesis. NATO ASI Series, vol 223. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1363-2_37
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DOI: https://doi.org/10.1007/978-1-4684-1363-2_37
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