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Asbestos Mediated Gene Expression in Rat Lung

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Mechanisms in Fibre Carcinogenesis

Part of the book series: NATO ASI Series ((NSSA,volume 223))

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Abstract

The term “asbestos” refers to a family of hydrated silicates with an aspect (length to diameter) ratio of > 3:1 as defined by regulatory policy in the United States. Physicochemical characteristics vary considerably amongst the various types of asbestos. Chrysotile asbestos [Mg6Si4O10(OH)8], the most common asbestos type, accounts for most of the world’s production of asbestos. Crocidolite asbestos [Na2Fe(III)2Fe(II)3Si8O22(OH)2], an iron containing fiber, belongs to the amphibole family. It is of less industrial importance than chrysotile but is more pathogenic than chrysotile in man in the causation of malignant mesothelioma (Mossman et al., 1990a).

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Author information

Authors and Affiliations

  1. Department of Pathology, University of Vermont, Burlington, Vermont, 05405, USA

    Yvonne M. W. Janssen, Joanne P. Marsh, Piyawan Surinrut, Kaaren Haldeman & Brooke T. Mossman

  2. Department of Occupational Medicine, University of Limburg, Maastricht, The Netherlands

    Paul J. A. Borm

Authors
  1. Yvonne M. W. Janssen
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  2. Joanne P. Marsh
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  3. Paul J. A. Borm
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  4. Piyawan Surinrut
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  5. Kaaren Haldeman
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  6. Brooke T. Mossman
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Editor information

Editors and Affiliations

  1. Medical Research Council Toxicology Unit, Carshalton, Surrey, UK

    Robert C. Brown  & John A. Hoskins  & 

  2. Inhalation Toxicology Research Institute, Albuquerque, New Mexico, USA

    Neil F. Johnson

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© 1991 Plenum Press, New York

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Janssen, Y.M.W., Marsh, J.P., Borm, P.J.A., Surinrut, P., Haldeman, K., Mossman, B.T. (1991). Asbestos Mediated Gene Expression in Rat Lung. In: Brown, R.C., Hoskins, J.A., Johnson, N.F. (eds) Mechanisms in Fibre Carcinogenesis. NATO ASI Series, vol 223. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1363-2_29

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  • DOI: https://doi.org/10.1007/978-1-4684-1363-2_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1365-6

  • Online ISBN: 978-1-4684-1363-2

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