Abstract
The biological activities of mineral fibres including their ability to cause disease are primarily related to their physical form. Fibres with widely different chemical compositions and composed of crystalline or amorphous materials can all cause the same biological effects if the fibres are within certain size ranges (Chamberlain & Brown, 1978, Stanton & Layard, 1978, Brown et al.1978, Pott et al., 1987; Donaldson et al., 1989). However to cause disease such fibres must persist in situ in animals or man for a period probably related to life span and therefore shorter in animals than man. In in vitro systems with a time of exposure only rarely exceeding a few days even very soluble fibres can exert an effect even if that effect is still dependent on fibre dimension.
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© 1991 Plenum Press, New York
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Brown, R.C., Hoskins, J.A., Sara, E.A., Evans, C.E., Cole, K.J. (1991). Fibre Size and Chemistry Effects in Vitro and in Vivo Compared. In: Brown, R.C., Hoskins, J.A., Johnson, N.F. (eds) Mechanisms in Fibre Carcinogenesis. NATO ASI Series, vol 223. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1363-2_12
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DOI: https://doi.org/10.1007/978-1-4684-1363-2_12
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