Abstract
The results of biological and physico-chemical investigations relating to fiber toxicology during the last decade indicate that a “black box” model could be developed for the correlation of the physical and chemical properties of fibrous particles and their toxic and carcinogenic effects. Fiber size, fiber persistency, fiber charge and catalytic properties show correlations to their experimentally determined biological effects. Practical importance of such correlations is discussed and a series of standardized screening tests is proposed.
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References
Barrett, J.C., Lamb, P.W. and Wiseman, R.W. (1989) Multiple mechanisms for the carcinogenic effects of asbestos and other mineral fibers. Environ. Hlth Perspect. 81: 81–89.
Bignon, J., Peto, J. and Saracci, R. (1989) Non-occupational exposure to mineral fibres. IARC Scientific Publications 90, Lyon, pp. 1–529.
Case, B.W. et al (1986) Asbestos effects on superoxide production. Environ. Res. 39: 299–306.
Graceffa, P. and Weitzman, S.A. (1987) Asbestos catalyzes the formation of the 6- oxobenzo(a)pyrene radical from 6-hydroxy-benzo-[al-pyrene. Arch. Biophys. 257: 481–484.
Jolicoer, C. and Pisson, D. (1987) Surface physico-chemical studies of chrysotile asbestos and related minerals. Drug Chem. Toxicol. 10: 1–47.
Korkina, L.G., Suslova, T.B., Cheremisina, Z.P. and Velichkovski, B.T. (1988) Catalytic proper- ties of asbestos fibers and their biological activity. Studia Biophysica 2: 99–104.
Light, W.G. and Wei, E.T. (1977) Surface charge and asbestos toxicity. Nature 265: 537–539.
McDonald, J.C., Amstrong, B., Case, B., Doell, D., McCaughey, T.E., McDonald, A.D. and Sebas- tien, P. (1989) Mesothelioma and asbestos fiber type. Cancer 63: 1544–1547.
Pinkerton, K.L., Brody, A.R., Miller, F.J. and Crapo, J.D. (1989) Exposure to low levels of ozone results in enhanced pulmonary retention of inhaled asbestos fibers. Am. Rev. Respir. Dis. 140: 1075–1081.
Pott, F. (1978) Some aspects of the dosimetry of the carconigenic potency of asbestos and other fibrous dust. Straub-Reinhalt Luft. 38: 486–489.
Pott, F. (1987) The fiber as a carcinogenic agent. Zbl. Bakt. Hyg. B 184: 1–23.
Scheule, R.K., Holian, A. (1989) I5G specifically enhances chrysotile asbestos-stimulated superox-ide anion production by alveolar macrophage. Am. J. Respir. Cell Mol. Biol. 1: 313–318.
Spurny, K.R. et al (1983) On the chemical changes of asbestos fibers and MMMFs in biologic residence and in the environment. Am. Ind. Hyg. Assoc. J. 11: 833–845.
Stanton, M.F., Layard, M., Tegeris, A., Miller, E., May, M. and Kent, E.J. (1977) Carcinogenesis of fibrous glass: pleural response in relation to fiber dimension. J. Natl. Cancer Inst. 58: 587–603.
Vasilieva, L.A., Pylev, L.N., Vezencev, A.I. and Smolikov, A.A. (1989) The carcinogenic activity of the synthetic chrysotile asbestos with different sizes of fibers and chemical composition. Exp. Oncology (Russ) 11: 26–29.
Walton, W.H. and Coppock, S.M. (1987) Man-made mineral fibres in the working environment. Ann. Occup. Hyg. 31B: 517–834.
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© 1991 Plenum Press, New York
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Spurny, K.R. (1991). Carcinogenic Effect Related to the Fiber Physics and Chemistry. In: Brown, R.C., Hoskins, J.A., Johnson, N.F. (eds) Mechanisms in Fibre Carcinogenesis. NATO ASI Series, vol 223. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1363-2_11
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DOI: https://doi.org/10.1007/978-1-4684-1363-2_11
Publisher Name: Springer, Boston, MA
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