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Clinical Studies

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Book cover Clinical Magnetic Resonance Spectroscopy

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Abstract

After a very slow start, the clinical application of MRS is now beginning to expand. This expansion is in part related to the increased availability in hospital environments of suitable high-field imaging spectrometers with bores up to whole-body diameter. Other factors are also involved. Although the modality has been shown to be effective in certain specialized fields, the more general usefulness of MRS in health care has only recently become apparent. With the primitive methods of signal localization available using a surface coil alone, investigations were initially limited to superficial tissues (e.g., skeletal muscle) and a few special situations. Clinical users of MRS now have a selection of effective localization methods, which show great promise and can be applied to studies with many different nuclei (see Chapter 5). These techniques permit the selection of a volume of interest from a series of 1H magnetic resonance images obtained from contiguous slices and the collection of spectroscopic data only from tissue within that selected volume. The power of these noninvasive biochemical assay methods is greatly enhanced by the fact that, in many tissues, magnetic susceptibility changes are small. This allows much better homogeneity of the field within the volume of interest and hence improved spectroscopic resolution.1 As a result, it is becoming evident that 1H and other nuclei will have a role in the future which will be as important as that of the 31P nucleus. In addition, localization techniques are now available which allow some degree of flexibility not only in the position and size of the sensitive volume but also in its orientation and shape.

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    Ernest B. Cady

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© 1990 Plenum Press, New York

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Cady, E.B. (1990). Clinical Studies. In: Clinical Magnetic Resonance Spectroscopy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1333-5_3

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