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Pharmacological Characterization of Insecticide-Binding Domains of the Voltage-Sensitive Sodium Channel

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Insecticide Action

Abstract

The voltage-sensitive sodium channel mediates the transient sodium permeability of the cell membrane that is associated with action potentials in vertebrate and invertebrate nerves and vertebrate skeletal muscle. Since this channel is gated by changes in cell membrane potential rather than by the binding of a ligand, it is not considered to be a “receptor” as that term is understood by neurobiologists. Nevertheless, the voltage-sensitive sodium channel has been shown to possess binding domains for a variety of potent neurotoxins, and it is implicated as the principal molecular target for the action of pyrethroid insecticides and DDT and its analogs. More recent studies have suggested that synthetic analogs of naturally-occurring N-alkylamide insecticides may also act at the sodium channel. In this paper, we summarize current information on the number and properties of neurotoxin binding domains on the voltage-sensitive sodium channel and review recent studies from this laboratory that implicate the involvement of these and other binding domains in the action of insecticides.

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Author information

Authors and Affiliations

  1. Department of Entomology New York State Agricultural Experiment Station, Cornell University, Geneva, NY, 14456, USA

    David M. Soderlund, Jeffrey R. Bloomquist, Gregory T. Payne & James A. Ottea

  2. Department of Entomology, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA

    Jeffrey R. Bloomquist

Authors
  1. David M. Soderlund
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  2. Jeffrey R. Bloomquist
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  3. Gregory T. Payne
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  4. James A. Ottea
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Editor information

Editors and Affiliations

  1. Northwestern University Medical School, Chicago, Illinois, USA

    Toshio Narahashi

  2. Mississippi State University, Mississippi State, Mississippi, USA

    Janice E. Chambers

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© 1989 Plenum Press, New York

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Soderlund, D.M., Bloomquist, J.R., Payne, G.T., Ottea, J.A. (1989). Pharmacological Characterization of Insecticide-Binding Domains of the Voltage-Sensitive Sodium Channel. In: Narahashi, T., Chambers, J.E. (eds) Insecticide Action. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1324-3_5

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  • DOI: https://doi.org/10.1007/978-1-4684-1324-3_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1326-7

  • Online ISBN: 978-1-4684-1324-3

  • eBook Packages: Springer Book Archive

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