Abstract
Clinical observation on various genetic combinations of sensory neural hearing impairments with pigmentation disorders (Schuknecht, 1974) as well as animal mutants (Schrott and Spoendlin, 1987; Steel et al., 1987) indicate a crucial position of the melanocytes onto the sensory areas. The audiological findings of minor susceptibility to noise exposure by pigmented animals and humans suggest an influence of melanin on inner ear physiology and pathophysiology (Conlee et al., 1986; Hood et al., 1976; Westerstrom, 1984; Tota and Bocci, 1967).
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References
Benedetto, J.-P., Ortonne, J. P., Voulot, C., Khatchadourian, C., Prota, G. and Thivolet, J., 1981, Role of thiol compounds in mammalian melanin pigmentation: part I. Reduced and oxidized glutathione, J. of Investigative Dermatology, 77:402–405.
Conlee, J. W., Khader, J. Addul-Baqi, McCandless, G. A. and Creel, D. J., 1986, Differential susceptibility to noise-induced permanent threshold shift between albino and pigmented guinea pigs, Hearing Res., 23:81–91.
Conlee, J. W., Parks, T. N., Romero, C. and Creel, D. J., 1984, Auditory brainstem anomalies in albino cats: II. neuronal atrophy in the superior olive, J. Comp. Neurol., 225:141–148.
Creel, D. J., Bendel, C. M., Wiesner, G. L., Wirtschfter, J. D., Arthur, D. O. and King, R. A., 1986, Abnormalities of the central visual pathway in Prader-Willi syndrome associated with hypopigmentation, New England Journal of Medicine, 314:1606–1609.
Dräger, U. C., 1985, Calcium binding in pigmented and albino eyes, Proc. Natl. Acad Sci. USA, 82:6716–6720.
Fain, G. L. and Schröder, W. H., 1987, Calcium in dark-adapted toad rods: Evidence for pooling and cyclic-guanosine-3’-5’-monophosphate- dependent release, J. Physiol., (in press).
Hilding, D. A. and Ginzberg, R. D., 1977, Pigmentation of the stria vascularis, Acta Otolaryngol. (Stockh) 84:24–37.
Hood, J. D., Poole, P. J. and Freedman, L., 1976, Eye color and susceptibility to TTS, J. Acoust. Soc. Am., 59:706–707.
Korytowski, Hintz, W. R., Sealy, R. C. and Kalzanaraman, B., 1985, Mechanism of dismutation of superoxide produce during autooxidation of melanin pigments, Biochem. Biophys. Res. Comm., 131:659–665.
Leventhal, A. H. and Vitek, D. J., Abnormal visual pathways in normally pigmented cats that are heterozygous for albinism, Science, 229.
Moorjani, P. A., Glenn, N. and Steel, K. P., 1986, Strial vasculature in mice with cochlea-saccular abnormalities, XXIII Workshop on Inner Ear Biology, Berlin
Meyer zum Gottesberge-Orsulakova and Kaufmann, R., Is an imbalanced calcium-homeostasis responsible for the experimentally induced endolymphatic hydrops? Acta Otolaryngol. (Stockh) 102:92–98.
Meyer zum Gottesberge-Orsulakova, A. M., 1986, Melanin in the inner ear: micromorphological and microanalytical investigations, Acta histochemica, Suppl. Band XXXII:245–253.
Meyer zum Gottesberge, A. M., 1988a, Modulation of melanocytes during experimentally induced endolymphatic hydrops, in press.
Meyer zum Gottesberge, A. M., 1988b, Microanalytical investigations of the inner ear, uveal tract and retina pigment epithelium melanin, Adv. of Bioscience, in press.
Negishi, S. and Obiha, M., 1985, The role of calcium and magnesium on pigment translocation in melanophores of Oryzions latipes. Pigment Cell, 235–259.
Orsulakova, A., Morgenstern, C., Kaufmann, R. and D’Haese, M., 1982, The laser microprobe mass analysis technique in the studies of the inner ear, Scanning Electron Microsc., 4:1763–1766.
Peters, T., 1986, Calcium in physiological and pathological cell function, European Neurology, 25:Suppl. 1, 27–44.
Schallreuter, K. U., Pittelkow, M. R., Gleason, F. K. and Wood, J. M., 1986, The role of calcium in the regulation of free radical reduction by thioredoxin reductase at the surface of the skin, J. of Inorganic Biochemistry, 28:227–238.
Schrott, A. and Spoendlin, H., 1987, Pigment anomaly-associad inner ear deafness, Acta Otolaryngol. (Stockh), 103:451–457.
Schuknecht, H. F., 1974, in: “Pathology in the inner ear”.
Sealy, R. C., Felix, C. C., Hyde, J. S. and Swartz, H. M., 1980, Structure and reactivity of melanin: Influence of free radicals and metal ions, Free Radicals in Biology, Vol. IV: 209–259.
Steel, K. P., Barkway, C. and Bock, G. R., 1987, Strial dysfunction in mice with cochleo-saccular abnormalities, Hearing Res. 27:11–26.
Tota, G. and Bocci, G., 1967, Importance of the color of the iris in the evaluation of resistance of hearing to fatigue, Riv. Otoneurooftal- mol., 43:183–192.
Wästerström, S. A., 1984, Accumulation of drugs on inner ear melanin, Scand. Audiol., Suppl. 23:1–40.
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© 1988 Plenum Press, New York
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zum Gottesberge, A.M.M., Schallreuter, K. (1988). Further Investigation About the Function of Inner Ear Melanin. In: Syka, J., Masterton, R.B. (eds) Auditory Pathway. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1300-7_5
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DOI: https://doi.org/10.1007/978-1-4684-1300-7_5
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