Skip to main content

Anatomy of the Mammalian Cochlear Nuclei; a Review

  • Chapter

Abstract

Nearly half a century after his first publications on the anatomy of the eighth nerve, Lorente de No (1981) portrayed “the primary acoustic nuclei” as “a miniature brain that has a cerebellum of its own, the tuberculum acousticum”. Here, selected aspects of this “brain” are discussed on the basis of recent literature. Included are also some preliminary immunocytochemical data from our institute (Osen et al., 1987), obtained by postembedding staining of 0.5 Aim resin sections of glutaraldehydefixed tissue, using locally produced antisera against conjugated glycine and GABA (Storm-Mathisen et al., 1983; Somogyi et al., 1984; Ottersen and Storm-Mathisen, 1984; Ottersen et al., 1987). As specificity tests are used preabsorption with amino acid glutaraldehyde complexes and coincubation with test sections containing six spatially separate amino acid conjugates (Ottersen, 1987).

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adams, J. C., 1979, Ascending projections to the inferior colliculus, J. Comp. Neurol., 183: 519–538.

    Article  PubMed  CAS  Google Scholar 

  • Adams, J. C., 1983, Multipolar cells in the ventral cochlear nucleus project to the dorsal cochlear nucleus and the inferior colliculus, Neurosci. Lett., 37:205–208.

    Article  PubMed  CAS  Google Scholar 

  • Arnesen, A. R. and Osen, K. K., 1978, The cochlear nerve in the cat: topography, cochleotopy, and fiber spectrum, J. Comp. Neurol., 178: 661–678.

    Article  PubMed  CAS  Google Scholar 

  • Blackstad, T. W., Osen, K. K. and Mugnaini, E., 1984, Pyramidal neurones of the dorsal cochlear nucleus: a Golgi and computer reconstruction study in cat, Neuroscience, 13:827–854.

    Article  PubMed  CAS  Google Scholar 

  • Bourk, T. R., Mielcarz, J. P. and Norris, B. E., 1981, Tonotopic organization of the anteroventral cochlear nucleus of the cat, Hearing Res., 4:215–241.

    Article  CAS  Google Scholar 

  • Brawer, J. R., Morest, D. K. and Kane, E. C., 1974, The neuronal architecture of the cochlear nucleus of the cat, J. Comp. Neurol., 155: 251–300.

    Article  PubMed  CAS  Google Scholar 

  • Brown, M. C., 1987, Morphology of labeled afferent fibers in the guinea pig cochlea, J. Comp. Neurol., 260:591–604.

    Article  PubMed  CAS  Google Scholar 

  • Cant, N. B. and Casseday, J. H., 1986, Projections from the anteroventral cochlear nucleus to the lateral and medial superior olivary nuclei, J. Comp. Neuro1., 247:457–476.

    Article  CAS  Google Scholar 

  • Cant, N. B. and Gaston, K. C., 1982, Pathways connecting the right and left cochlear nuclei, J. Comp. Neurol., 212:313–326.

    Article  PubMed  CAS  Google Scholar 

  • Cant, N. B. and Morest, D. K., 1978, Axons from non-cochlear sources in the anteroventral cochlear nucleus of the cat. A study with the rapid Golgi method, Neuroscience, 3:1003–1029.

    Article  PubMed  CAS  Google Scholar 

  • Cant, N. B. and Morest, D. K., 1979, Organization of the neurons in the anterior division of the anteroventral cochlear nucleus of the cat. Light-microscopic observations, Neuroscience, 4:1909–1923.

    Article  PubMed  CAS  Google Scholar 

  • Caspary, D. M., Rybak, L. P. and Faingold, C. L., 1985, The effects of inhibitory and excitatory amino-acid neurotransmitters on the response properties of brainstem auditory neurons, in: “Auditory biochemistry”, D. G. Drescher, ed., Charles C. Thomas Publ., Springfield Ill.

    Google Scholar 

  • Faye-Lund, H. and Osen, K. K., 1985, Anatomy of the inferior colliculus in rat, Anat. Embryo1., 171:1–20.

    Article  CAS  Google Scholar 

  • Hackney, C. M. and Pick, G. F., 1986, The distribution of spherical cells in the anteroventral cochlear nucleus of the guinea pig. Brit. J. Audiol., 20:215–220.

    Article  CAS  Google Scholar 

  • Harrison, J. M. and Feldman, M. L., 1970, Anatomical aspects of the cochlear nucleus and superior olivary complex, in: “Contributions to sensory physiology”, W. D. Neff, ed., Academic Press, New York and London.

    Google Scholar 

  • Harrison, J. M. and Irving, R., 1964, Nucleus of the trapezoid body: dual afferent innervation, Science, 143:473–474.

    Article  PubMed  CAS  Google Scholar 

  • Harrison, J. M. and Irving, R., 1965, The anterior ventral cochlear nucleus, J. Comp. Neurol., 124:15–21.

    Article  PubMed  CAS  Google Scholar 

  • Harrison, J. M. and Irving, R., 1966, The organization of the posterior ventral cochlear nucleus in the rat, J. Comp. Neurol., 126:391–402.

    Article  PubMed  CAS  Google Scholar 

  • Itoh, K., Nomura, S., Konishi, A., Yasui, Y., Sugimoto, T. and Muzino, N., 1986, A morphological evidence of direct connections from the cochlear nuclei to tensor tympani motoneurons in the cat: a possible afferent limb of the acoustic middle ear reflex pathways, Brain. Res., 375:214–219.

    Article  PubMed  CAS  Google Scholar 

  • Itoh, K., Kamiya, H., Mitani, A., Yasui, Y., Takada, M. and Mizuno, N., 1987, Direct projections from the dorsal column nuclei and the spinal trigeminal nuclei to the cochlear nuclei in the cat, Brain Res., 400:145–150.

    Article  PubMed  CAS  Google Scholar 

  • Liberman, M. C. and Simmons, D. D., 1985, Applications of neuronal labeling techniques to the study of the peripheral auditory system, J. Acoust. Soc. Am., 78:312–319.

    Article  PubMed  CAS  Google Scholar 

  • Lorente de Nó, R., 1933, Anatomy of the eighth nerve. III. General plan of structure of the primary cochlear nuclei, Laryngoscope, 43:327–350.

    Google Scholar 

  • Lorente de Nó, R., 1981, “The primary acoustic nuclei”, Raven Press, New York.

    Google Scholar 

  • Moore, J. K., 1980, The primate cochlear nuclei: loss of lamination as a phylogenetic process, J. Comp. Neurol., 193:609–629.

    Article  PubMed  CAS  Google Scholar 

  • Mugnaini, E., 1985, GABA neurons in the superficial layers of the rat dorsal cochlear nucleus: light and electron microscopic immunocy- tochemistry, J. Comp. Neurol., 235:61–81.

    Article  PubMed  CAS  Google Scholar 

  • Mugnaini, E., Osen, K. K., Dahl, A.-L., Friedrich, V. L., jr., and Korte, G., 1980, Fine structure of granule cells and related interneurons (termed Golgi cells) in the cochlear nuclear complex of cat, rat and mouse, J. Neurocytol., 9:537–570.

    Article  PubMed  CAS  Google Scholar 

  • Osen, K. K., 1969a, Cytoarchitecture of the cochlear nuclei in the cat, J. Comp. Neurol., 136:453–484.

    Article  PubMed  CAS  Google Scholar 

  • Osen, K. K., 1969b, The intrinsic organization of the cochlear nuclei in the cat, Acta Otolaryngol., 67:352–359.

    Article  PubMed  CAS  Google Scholar 

  • Osen, K. K., 1970, Course and termination of the primary afferents in the cochlear nuclei of the cat. An experimental anatomical study, Arch. Ital. Biol., 108:21–51.

    PubMed  CAS  Google Scholar 

  • Osen, K. K., 1983, Orientation of dendritic arbors studied in Golgi sections of the cat dorsal cochlear nucleus, in: “Mechanisms of hearing”, W. R. Webster and L. M. Aitkin, eds., Monash University Press, Clayton.

    Google Scholar 

  • Osen, K. K., Ottersen, O. P. and Storm-Mathisen, J., 1987, Glycine-like immunoreactivity in the rat dorsal cochlear nucleus (DCN), Neuroscience, Suppl. 22:S788.

    Google Scholar 

  • Ottersen, O. P., 1987, Postembedding light- and electron microscopic immunocytochemistry of amino acids: description of a new model system allowing identical conditions for specificity testing and tissue processing, Exp. Brain Res., (in press).

    Google Scholar 

  • Ottersen, O. P., Davanger, S. and Storm-Mathisen, J., 1987, Glycine-like immunoreactivity in the cerebellum of rat and Senegalese baboon, Papio papio: a compari3son with the distribution of GABA-like immunoreactivity and with H glycine and H GABA uptake, Exp. Brain Res., 66:211–221.

    Article  PubMed  CAS  Google Scholar 

  • Ottersen, O. P. and Storm-Mathisen, J., 1984, Glutamate- and GABA- containing neurons in the mouse and rat brain, as demonstrated with a new immunocytochemical technique, J. Comp. Neurol., 229:374–392.

    Article  PubMed  CAS  Google Scholar 

  • Rouiller, E. M., Cronin-Schreiber, R., Fekete, D. M. and Ryugo, D. K., 1986, The central projections of intracellularly labeled auditory nerve fibers in cats: an analysis of terminal morphology. J. Comp. Neurol., 249:261–278.

    Article  PubMed  CAS  Google Scholar 

  • Smith, P. H. and Rhode, W. S., 1985, Electron microscopic features of physiologically characterized, HRP-labeled fusiform cells in the cat dorsal cochlear nucleus, J. Comp. Neurol., 237:127–143.

    Article  PubMed  CAS  Google Scholar 

  • Somogyi, P., Hodgson, A. J., Smith, A. D., Nunzi, M. G., Gorio, A. and Wu, J.-Y., 1984, Different populations of GABA ergic neurons in the visual cortex and hippocampus of cat contains somatostatin- or cholecystokinin-immunoreactive material, J. Neurosci., 4:2590–2603.

    PubMed  CAS  Google Scholar 

  • Storm-Mathisen, J., Leknes, A. K., Bore, A. T., Vaaland, J. L., Edminson, P., Haug, F.-M. S. and Ottersen, O. P., 1983, First visualization of glutamate and GABA in neurones by immunocytoche- mistry, Nature, London, 301:517–520.

    Article  CAS  Google Scholar 

  • Wenthold, R. J., 1987, Evidence for a glycinergic pathway connecting the two cochlear nuclei; an immunocytochemical and retrograde transport study, Brain Res., 415:183–187.

    Article  PubMed  CAS  Google Scholar 

  • Wouterlood, F. G., and Mugnaini, E., 1984, Cartwheel neurons of the dorsal cochlear nucleus: A Golgi-electron microscopic study in rat, J. Comp. Neurol., 227:136–157.

    Article  PubMed  CAS  Google Scholar 

  • Wouterlood, F. G., Mugnaini, E., Osen, K. K. and Dahl, A.-L., 1984, Stellate neurons in rat dorsal cochlear nucleus studied with combined Golgi impregnation and electron microscopy: synaptic connections and mutual coupling by gap junctions, J. Neurocytol., 13: 639–664.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Plenum Press, New York

About this chapter

Cite this chapter

Osen, K.K. (1988). Anatomy of the Mammalian Cochlear Nuclei; a Review. In: Syka, J., Masterton, R.B. (eds) Auditory Pathway. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1300-7_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-1300-7_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1302-1

  • Online ISBN: 978-1-4684-1300-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics