Cellular and Tissue Mechanisms of Primate Uterine Endometrial Renewal: An Hypothesis

  • Helen A. Padykula
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 230)


Recent advances in hormonal regulation of cyclic uterine differentiation and preimplantation biology are evident in the remarkable announcements that normal live primate newborns can be produced through artificial menstrual cycles in ovariectomized rhesus monkeys and women (1–3). Such fertile menstrual cycles are produced in rhesus monkeys by a program of insertion and removal of subcutaneous silastic implants of estradiol and progesterone that serve as effective “artificial ovaries” until the placenta takes over the maintenance of pregnancy. These tangible demonstrations provide new stimulus for experimental analysis of endometrial cell and tissue compartments in the primate (rhesus) uterus with regard to the hormonal mechanisms that control cyclic renewal.


Menstrual Cycle Rhesus Monkey Luteal Phase Endometrial Cell Germinal Cell 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Helen A. Padykula
    • 1
  1. 1.Department of AnatomyUniversity of Massachusetts Medical SchoolWorcesterUSA

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