Abstract
Correlated approaches (as in title) have been used to assess mechanisms of metal- or metalloid-induced cell injury following in vivo (usually rat) exposure to these agents. Relationships have been studied between indium- and thallium-induced perturbations of hepatic haem metabolism and associated changes in e.r.* and mitochondrial membrane structure. Seemingly such structural changes largely mediate the inhibitions of cytochrome P-450-dependent enzyme activities observed following acute administration of various metals.
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© 1987 Plenum Press, New York
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Fowler, B.A. (1987). Ultrastructural Morphometric/Biochemical Approaches to Assessing Metal-Induced Cell Injury. In: Reid, E., Cook, G.M.W., Luzio, J.P. (eds) Cells, Membranes, and Disease, Including Renal. Methodological Surveys in Biochemistry and Analysis, vol 17. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1283-3_9
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DOI: https://doi.org/10.1007/978-1-4684-1283-3_9
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