Abstract
Although proliferation of mitochondria has been noted in the liver of patients suffering from a number of illnesses, the relation of this phenomenon to the disease is not known. Several liver carcinogens are known to induce mitochondrial proliferation shortly after administration; but again, the relationship to hepatocarcinogenesis is not known. Several carcinogens having this effect are not detectably mutagenic, suggesting that their effect on mitochondria might be related to carcinogenesis. The most notable mitochondrial-proliferation carcinogens are methapyrilene (formerly a commonly used antihistaminic), diethylhexylphthalate (DEHP; a widely used plasticizer), nitrosodiethanolamine and nitrosomethylethanolamine (both contaminants of cutting oils and cosmetics). Methapyrilene induces liver tumours in rats, but not in other species, and several structurally close analogues are not carcinogenic. These analogues do not induce mitochondrial proliferation, nor does methapyrilene in species other than the rat.
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© 1987 Plenum Press, New York
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Lijinsky, W. (1987). Drug-Induced Mitochondrial Proliferation. In: Reid, E., Cook, G.M.W., Luzio, J.P. (eds) Cells, Membranes, and Disease, Including Renal. Methodological Surveys in Biochemistry and Analysis, vol 17. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1283-3_8
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DOI: https://doi.org/10.1007/978-1-4684-1283-3_8
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