Abstract
With emphasis on methodology, this article concerns effects, in the rat, of LL\(\otimes\) drugs (clofibrate, fenofibrate) and DEEP, administered for up to 18 months. Short-term alterations were also studied in hepatocytes, both freshly isolated and cultured. Alterations were found in the liver, as eozpected, and in several other tissues. Similarly to liver, the kidney proximal tubule showed an initial increase in peroxisomes and then an enlargement of lysosomes which were filled with material staining as for lipofuscin. The pancreas showed exocrine-cell hyperactivity, and with prolonged treatment the islets did not show the hypertrophy normally observed in ageing rats. All the alterations may well relate to alterations in fat metabolism.
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© 1987 Plenum Press, New York
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Price, S.C. et al. (1987). Studies on the Mechanisms of Changes Produced in the Liver, Thyroid, Pancreas and Kidney by Hypolipidaemic Drugs and DI-(2-Ethylhexyl) Phthalate. In: Reid, E., Cook, G.M.W., Luzio, J.P. (eds) Cells, Membranes, and Disease, Including Renal. Methodological Surveys in Biochemistry and Analysis, vol 17. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1283-3_6
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DOI: https://doi.org/10.1007/978-1-4684-1283-3_6
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