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Pharmacological and Toxicological Aspects of Peroxisome Proliferators

  • Chapter
Cells, Membranes, and Disease, Including Renal

Part of the book series: Methodological Surveys in Biochemistry and Analysis ((MSBA,volume 17))

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Abstract

In male rats, LL* drugs including clofibrate, tiadenol, niadenate, nicotinic acid and cholestyramine differed in their effects on hepatic enzymic activities involved in long-chain fatty acyl-CoA (pyCoA) formation and breakdown, and on peroxisome \(\bar{\text S}\) values that could explain some of the observed changes in s.a.’s of fatty acid metabolizing enzymes with multiple subcellular localization. Long-chain acyl-CoA content was strongly correlated with pyCoA hydrolase and peroxisomal β-oxidation activity (which bring about peroxisomal proliferation), pointing to a common regulation mechanism for the enzymes.

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References

  1. Baggio, C., Briani, G., Fellin, R., Martini, S., Baiocchi, M.R. & Crepaldi, C. (1979) Artery 5, 486–494.

    Google Scholar 

  2. Saba, P., Paglial, E., Scalabrino, A., Galeone, F., Giuntoli, F., Guidi, G., Morini, S. & Lavoratti, G. (1980) Curr. Ther. Res. 27, 677–683.

    Google Scholar 

  3. Miettinen, T.A. (1976) in Lipid Pharmacology (Paoletti, R. & Glueck, C.I., eds.), Vol. 2, Academic Press, New York, pp. 83–87.

    Google Scholar 

  4. Grundy, S.M., Mok, H.Y.I., Zech, L. & Berman, M. (1983) J. Lipid Res. 22, 24–30.

    Google Scholar 

  5. Gibbons, G.F., Mitropoulos, K.A. & Myant, N.B. (1982) Biochemistry of Cholesterol, Elsevier, Amsterdam.

    Google Scholar 

  6. Dietschy, I.M. & Brown, M. (1974) J. Lipid Res. 15, 508–516.

    PubMed  CAS  Google Scholar 

  7. Berge, R.K. & Bakke, O.M.(1981) Biochem. Pharmacol. 30, 2251–2256.

    Article  PubMed  CAS  Google Scholar 

  8. Berge, R.K. & Aarsland, A. (1985) Biochim. Biophys. Acta 837, 141–151.

    PubMed  CAS  Google Scholar 

  9. Svoboda, D.I. & Azarnoff, D.L. (1971) Cancer Res. 39, 3419–3428.

    Google Scholar 

  10. Cohen, A.I. & Grasso, P. (1981) Food Cosmet. Toxicol. 19, 585–605.

    Article  PubMed  CAS  Google Scholar 

  11. Lalwani, N.D., Reddy, J.K., Gureshi, S.A., Reddy, M.K. & Moehle, C.M. (1984)Am. J. Path. 114, 171–174.

    PubMed  Google Scholar 

  12. Hashimoto, T. (1982) Ann. N.Y. Acad. Sci. 386, 5–13.

    Article  PubMed  CAS  Google Scholar 

  13. Reddy, J.K., Azarnoff, D.L. & Hignite, C.E. (1980) Nature 283, 397–398.

    Article  PubMed  CAS  Google Scholar 

  14. Berge, R.K. & Thomassen, M.S. (1984) Lipids 20, 49–52.

    Article  Google Scholar 

  15. Thomassen, M.S., Christiansen, E.N. & Norum, K.R. (1982) Biochem. J. 206, 195–202.

    PubMed  CAS  Google Scholar 

  16. Berge, R.K. (1980) Biochim. Biophys. Acta 574, 321–323.

    Google Scholar 

  17. Berge, R.K., Fiatmark, T. & Osmundsen, H. (1984) Eur. J. Biochem., 141, 637–644.

    Article  PubMed  CAS  Google Scholar 

  18. de Duve, C., Pressman B.C., Gianetto, R., Wattiaux, R. & Appelmans, F. (1955) Biochem. J. 60, 604–617.

    Google Scholar 

  19. Berge, R.K. & Farstad, M. (1981) Meths. Enzymol. 71, 234–242.

    Article  CAS  Google Scholar 

  20. Berge, R.K., Slinde, E. & Farstad, M. (1980) Biochim. Biophys. Acta 666, 25–35.

    Google Scholar 

  21. Bakke, O.M. & Berge, R.K. (1984) Biochem. Pharmacol.33, 3077–3080.

    Article  PubMed  CAS  Google Scholar 

  22. Berge, R.K., HosØy, L.H. & Farstad, M. (1984) Int. J. Biochem. 16, 403–410.

    Article  PubMed  CAS  Google Scholar 

  23. Fiatmark, T., Christiansen, E.N. & Kryvi, H. (1981) Eur. J. Cell Biol. 24, 62–69.

    Google Scholar 

  24. Sakurai, T., Miyazawa, S., Osumi, T., Furuta, S. & Hasimoto, T. Toxicol. Appl. Pharmacol. 59, 8–18.

    Google Scholar 

  25. Ishii, H. & Suga, T. (1979) Biochem. Pharmacol. 28, 2829–2834.

    Article  PubMed  CAS  Google Scholar 

  26. Mentlein, R., Lembke, B., Vik, H. & Berge, R.K. (1986) Biochem. Pharmacol. 35, 2727–2730.

    Article  PubMed  CAS  Google Scholar 

  27. Lygre, T., Aarsaether, N., Stensland, E. & Berge, R.K. (1986) J. Chromatog. 381, 95–105.

    Article  CAS  Google Scholar 

  28. Cappuizzi, P.M., Intenzo, C.M., Lackman, R.D., Whereat, A.F. & Scott, D.M. (1985) Biochem. Pharmacol. 32, 2195–2203.

    Article  Google Scholar 

  29. Lillehaug, I.R., Aarsaether, N. Berge, R.K., & Male, R. (1986) Int. J. Cancer 39, 97–100.

    Article  Google Scholar 

  30. Berge, R.K. & Lillehaug, I.R. (1985) Int. J. Cancer 36, 489–494.

    Article  PubMed  CAS  Google Scholar 

  31. Price, S.C., Hall, D.E. & Hinton, R.H. (1985) Toxicol. Lett. 25, 11–13.

    Article  PubMed  CAS  Google Scholar 

  32. Mentlein, R., Schumann, M. & Heymann, E. (1985) Arch. Biochem. Biophys. 234, 612–621.

    Article  Google Scholar 

  33. Mentlein, R., Berge, R.K. & Heymann, E. (1985) Biochem. J. 232, 479–483.

    PubMed  CAS  Google Scholar 

  34. Mondal, S., Brankow, D.W. & Heidelberger, C. (1975) Cancer Res. 36, 2254–2260.

    Google Scholar 

  35. Fahl, W.E., Lalwani, N.D., Watanabe, T., Goel, S.K. & Reddy, I.K. (1984)Proc. Nat. Acad. Sci. 81, 7827–7831.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Laboratory of Clinical Biochemistry, University of Bergen, N-5016, Haukeland Sykehus, Bergen, Norway

    R. K. Berge, N. Aarsæther, A. Aarsland & T. Ghezai

Authors
  1. R. K. Berge
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  2. N. Aarsæther
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  3. A. Aarsland
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  4. T. Ghezai
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Editor information

Editors and Affiliations

  1. Guildford Academic Associates, 72 The Chase, GU2 5UL, Guildford, UK

    Eric Reid

  2. University of Cambridge, Cambridge, UK

    G. M. W. Cook  & J. P. Luzio  & 

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© 1987 Plenum Press, New York

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Berge, R.K., Aarsæther, N., Aarsland, A., Ghezai, T. (1987). Pharmacological and Toxicological Aspects of Peroxisome Proliferators. In: Reid, E., Cook, G.M.W., Luzio, J.P. (eds) Cells, Membranes, and Disease, Including Renal. Methodological Surveys in Biochemistry and Analysis, vol 17. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1283-3_5

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  • DOI: https://doi.org/10.1007/978-1-4684-1283-3_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1285-7

  • Online ISBN: 978-1-4684-1283-3

  • eBook Packages: Springer Book Archive

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