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Studies of the Mechanisms of Mucosal Iron Uptake

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Cells, Membranes, and Disease, Including Renal

Part of the book series: Methodological Surveys in Biochemistry and Analysis ((MSBA,volume 17))

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Abstract

Brush border membrane can be isolated as closed vesicles, and transport components of 59Fe2+ and 59Fe3+ uptake by brush border membrane vesicles have been identified. This brush border membrane transport is subject to adaptive regulation in response to varying whole-body iron requirements and accounts quantitatively and qualitatively for in vivo mucosal 59Fe2+ uptake but not 59Fe3+ uptake. Investigation of the mechanism of 59Fe2+ transport by rabbit brush border membrane vesicles has led to the isolation of a membrane Fe2+- binding constituent, identified as non-esterified fatty acid (NEFA).

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References

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Author information

Authors and Affiliations

  1. Division of Clinical Cell Biology, MRC Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK

    Robert J. Simpson & Timothy J. Peters

Authors
  1. Robert J. Simpson
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  2. Timothy J. Peters
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Editor information

Editors and Affiliations

  1. Guildford Academic Associates, 72 The Chase, GU2 5UL, Guildford, UK

    Eric Reid

  2. University of Cambridge, Cambridge, UK

    G. M. W. Cook  & J. P. Luzio  & 

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© 1987 Plenum Press, New York

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Simpson, R.J., Peters, T.J. (1987). Studies of the Mechanisms of Mucosal Iron Uptake. In: Reid, E., Cook, G.M.W., Luzio, J.P. (eds) Cells, Membranes, and Disease, Including Renal. Methodological Surveys in Biochemistry and Analysis, vol 17. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1283-3_27

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  • DOI: https://doi.org/10.1007/978-1-4684-1283-3_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1285-7

  • Online ISBN: 978-1-4684-1283-3

  • eBook Packages: Springer Book Archive

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