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Cells, Membranes, and Disease, Including Renal pp 255–267Cite as

Structural and Functional Aspects of the Intestinal Brush Border

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Part of the book series: Methodological Surveys in Biochemistry and Analysis ((MSBA,volume 17))

Abstract

The small intestinal brush border membrane contains several peptidases and glycosidases of importance for the final digestion of proteins and carbohydrates. These enzymes typically have a main portion in the intestinal lumen and a small N-terminal portion anchoring them to the membrane. Certain maldigestion diseases can be explained by deficient expression of these enzymes. The enzymes are synthesized in the rough e.r.* and transported to the brush border membrane via the Golgi apparatus, where they are modified. Disturbances in these processes may cause depressed enzyme activities; thus sucraseisomaltase is not fully active if incompletely glycosylated.

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Authors and Affiliations

  1. Department of Biochemistry C The Panum Institute, University of Copenhagen, Blegdamsvej 3C, DK-2200, Copenhagen N, Denmark

    G. M. Cowell, E. M. Danielsen, S. U. Friis, S. U. Gorr, G. H. Hansen, O. Norén, H. Sjöström & H. Skovbjerg

Authors
  1. G. M. Cowell
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  2. E. M. Danielsen
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  3. S. U. Friis
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  4. S. U. Gorr
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  5. G. H. Hansen
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  6. O. Norén
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  7. H. Sjöström
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  8. H. Skovbjerg
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Editor information

Editors and Affiliations

  1. Guildford Academic Associates, 72 The Chase, GU2 5UL, Guildford, UK

    Eric Reid

  2. University of Cambridge, Cambridge, UK

    G. M. W. Cook  & J. P. Luzio  & 

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© 1987 Plenum Press, New York

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Cowell, G.M. et al. (1987). Structural and Functional Aspects of the Intestinal Brush Border. In: Reid, E., Cook, G.M.W., Luzio, J.P. (eds) Cells, Membranes, and Disease, Including Renal. Methodological Surveys in Biochemistry and Analysis, vol 17. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1283-3_26

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  • DOI: https://doi.org/10.1007/978-1-4684-1283-3_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1285-7

  • Online ISBN: 978-1-4684-1283-3

  • eBook Packages: Springer Book Archive

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