Abstract
Tissue biopsy samples have routinely been used for diagnostic purposes for nearly a century. More recently, such material has been employed for biochemical investigations. Studies of organelle abnormalities can be quantitatively assessed by marker enzyme analysis (e.g. N-acetyl-β-glucosaminidase and acid phosphatase for lysosomes, lactate dehydrogenase for cytosol) in combination with subcellular fractionation by density-gradient centrifugation. Thereby hitherto unassigned enzymes etc. can be localized.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Peters, T.J. (1981) J. Clin. Path. 34, 1–12.
O’Morain, C., Smethurst, P., Levi, A.J. & Peters, T.J. (1983) J. Clin. Path. 36, 1312–1316.
Krawisz, J.E., Sharon, P. & Stenson, W.F. (1984) Gastroenterology 87, 1344–1350.
Abraham, R., Fabian, R.J., Goldberg, L. & Coulston, F. (1974) Gastroenterology 67, 1169–1181.
O’Morain, C., Smethurst, P., Levi, A.J. & Peters, T.J. (1985) Scand. J. Gastroenterology 20, 209–214.
O’Morain, G., Smethurst, P., Levi, A.J. & Peters, T.J. (1984) Gut 25, 455–459.
Danovitch, S.H., Gallucci, A. & Shora, W. (1972) Am. J. Digest. Dis. 17, 977–992.
Binder, V., Soltoft, J. & Gudmand-Hoyer, E. (1974) Scand. J. Gastroenterology 9, 293–297.
Kane, S.P. & Vincent, A.C. (1979) Clin. Sci. 57, 295–303.
Peters, T.J. & Bjarnason, I. (1985) in Food and the Gut (Hunter, J.O. & Alun Jones, V., eds.), Baillière Tindall, London, pp. 30–44.
Bjarnason, I., Peters, T.J. & Levi, A.J. (1986) Digest. Dis. 4, 83–92.
Bjarnason, I. & Peters, T.J. (1984) Gut 25, 145–150.
Bjarnason, I., O’Morain, C., Levi, A.J. & Peters, T.J. (1983) Gastroenterology 85, 318–322.
O’Morain, C., Peters, T.J. & Veall, N. (1983) Lancet i, 323–325.
Bjarnason, I., Ward, K. & Peters, T.J. (1984) Lancet i, 179–182.
Cox, T.M. & Peters, T.J. (1979) J. Physiol. 289, 469–478.
Cox, T.M. & Peters, T.J. (1978) Lancet i, 123–124.
Duncombe, V.M., Watts, R.W.E. & Peters, T.J. (1980) Lancet ii, 1334–1336.
Scott, J. & Peters, T.J. (1983) Am. J. Physiol. 244, G532–540.
Hamilton, J.W., Li, B., Shug, A.L. & Olsen, W.A. (1986) Gastroenterology 91, 10–16.
Duncombe, V.M., Watts, R.W.E. & Peters, T.J. (1984) Quart. J. Med. 54, 69–79.
L’Hirondel, C., Doe, W.F. & Peters, T.J. (1976) Clin. Sci. Mol. Med. 50, 425–429.
Jones, P.E., L’Hirondel, C. & Peters, T.J. (1981) Gut 22, 623–627.
Jones, P.E. & Peters, T.J. (1977) Br. Med. J. i, 1130–1134.
Jones, P.E., L’Hirondel, C. & Peters, T.J. (1982) Gut 23, 108–114.
Lieber, C.S. (1985) Acta Med. Scand. (Suppl.) 703, 11–55.
Venkatesan, S., Leung, N.W.Y. & Peters, T.J. (1986) Clin. Sci. 71, 723–728.
Jungas, R.L. (1968) Biochemistry 7, 3708–3717.
Venkatesan, S., Ward, R.J. & Peters, T.J. (1987) Clin. Sci., in press.
Leung, N.W.Y. & Peters, T.J. (1986) Clin. Sci. 71, 253–260.
Jenkins, W.J. & Peters, T.J. (1978) Gut 19, 341–344.
Fischel, P. & Oette, K. (1974) Res. Exp. Med. 163, 1–16.
Grunnet, N., Kondrup, J. & Dich, J. (1985) Biochem. J. 228, 673–681.
Peters, T.J. & Cairns, S.R. (1985) Alcohol 2, 447–451.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Plenum Press, New York
About this chapter
Cite this chapter
Peters, T.J. (1987). Investigation of Subcellular Derangements in Human Biopsy Material. In: Reid, E., Cook, G.M.W., Luzio, J.P. (eds) Cells, Membranes, and Disease, Including Renal. Methodological Surveys in Biochemistry and Analysis, vol 17. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1283-3_2
Download citation
DOI: https://doi.org/10.1007/978-1-4684-1283-3_2
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-1285-7
Online ISBN: 978-1-4684-1283-3
eBook Packages: Springer Book Archive