Abstract
Mouse hepatitis virus (MHV) is a member of the family Coronaviridae and known to induce various types of disease, hepatitis, enteritis and encephalitis in mice depending upon the host strain, age, and immune status1. Using nude or immunomodulated mice, T cell-mediated immunity in MHV infections was suggested to play an important role.2, 3 By the adoptive transfer of spleen cells from immune euthymic mice the growth of MHV in the recipient nude mice was inhibited, and the transfer effect was abolished by treating immune spleen cells with anti-BAT serum and complement3.
Chapter PDF
References
H. Wege, S. Siddell, and V. ter Meulen, The biology and pathogenesis of coronaviruses, Curr. Top. Microbiol. Immunol. 99: 165 (1982).
J. M. Dupuy, E. Levey-Leblond, and C. Le Prévost, Immunopathology of mouse hepatitis virus type 3 infection. II. Effect of immunosuppession in resistant mice, J. Immunol. 114: 226 (1975).
C. Kai, T. Tamura, and K. Fujiwara, Effect of immune heterozygous spleen cell transfer on resistance to mouse hepatitis virus infection in nude mice, Microbiol. Immunol. 25: 1011 (1981).
S. A. Stohlman, G. K. Matsushima, N. Casteel, and L. P. Weiner, In vivo effects of coronavirus-specific T cell clones: DTH inducer cells prevent a lethal infection but do not inhibit virus replication, J. Immunol. 136: 3052 (1986).
H. C. J. Ertl and R. W. Finberg, Characteristics and function of Sendai virus-specific T cell clones, J. Virol. 50: 425 (1984).
S. Kyuwa and K. Fujiwara, Delayed-type hypersensitivity in mouse hepatitis virus infection in mice, Japan J. Exp. Med. 54: 81 (1984).
J. G. Woodward, G. Matsushima, J. A. Frelinger, and S. A. Stohlman, Production and characterization of T cell clones specific for mouse hepatitis virus, strain JHM: in vivo and in vitro analysis, J. Immunol. 133: 1016 (1984).
T. J. Braciale, M. E. Andrew, and V. L. Braciale, Heterogeneity and specificity of cloned lines of influenza virus-specific cytotoxic T lymphocytes, J. Exp. Med. 153: 910 (1981).
J. A. Byrne and M. B. A. Oldstone, Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo, J. Virol. 51: 682 (1984).
K. Fujiwara, Problems in checking innaparent infections in laboratory mouse colonies. An attempt at serological checking by anamnestic response, in: “Defining of the laboratory animals”, H. A. Scheneider, ed., National Academy of Science, Washington, D. C. (1971).
N. Hirano, K. Fujiwara, S. Hino, and M. Matsumoto, Replication and plaque formation of mouse hepatitis virus(MHV-2) in mouse cell line DBT culture, Arch. Ges. Virusforsh. 44: 298 (1974).
S. Gillis, M. M. Fera, W. Ou, and K. A. Smith, T cell growth factor: parameters of production and a quantitative microassay for activity, J. Immunol. 120: 2027 (1978).
T. M. Dexter, J. Garland, D. Scott, E. Scolnick, and D. Metcalf, Growth of factor-dependent hemopoietic precursor cell lines, J. Exp. Med. 152: 1036 (1980).
E. De Maeyer and J. De Maeyer-Guignard, Delayed-type hypersensitivity to Nescastle disease virus in high and low inferferon-producing mice, J. Immunol. 130: 2392 (1983).
D. P. Dialynas, Z. S. Quan, K. A. Wall, A. Pierres, J. Quintan, M. R. Loken, M. Pierres, and F. W. Fitch, Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Lue-3/T4 molecule, J. Immunol. 131: 2445 (1983).
A. L. Glasebrook, M. Sarmiento, M. R. Loken, D. P. Dialynas, J. Quintans, L. Eisenberg, C. T. Lutz, D. Wilde, and F. W. Fitch, Murine T lymphocyte clone with distinct immunological functions, Immuno. Rev. 54: 225 (1981).
D. A. Morgan, F. W. Ruscetti, and R. Gallo, Selective in vitro growth of T lymphocytes from normal human bone marrows, Science 193: 1007 (1976).
S. Gillis and K. A. Smith, Long term culture of tumor-specific cytotoxic T cells, Nature 268: 154 (1977).
T. Suda, J. Suda, M. Ogawa, and J. M. Ihle, Permissive role of interleukin 3(IL 3) in proliferation and differentiation of multipotential hemopoietic progenitors in culture, J. Cell. Physiol. 124: 182 (1985).
A. A. Nash and P. G. H. Gell, Membrane phenotype of murine effector and suppressor T cells involved in delayed hypersensitivity and protective immunity to herpes simplex virus, Cell. Immunol. 75: 348 (1983).
R. D. Schrier, L. I. Pizer, and J. W. Moorhead, Type-specific delayed hypersensitivity and protective immunity induced by isolated herpes simplex virus glycoprotein, J. Immuni. 130: 1413 (1983).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Plenum Press, New York
About this chapter
Cite this chapter
Kyuwa, S., Yamaguchi, K., Hayami, M., Fujiwara, K. (1987). Characterization of Mouse Hepatitis Virus-Reactive T Cell Clones. In: Lai, M.M.C., Stohlman, S.A. (eds) Coronaviruses. Advances in Experimental Medicine and Biology, vol 218. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1280-2_48
Download citation
DOI: https://doi.org/10.1007/978-1-4684-1280-2_48
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-1282-6
Online ISBN: 978-1-4684-1280-2
eBook Packages: Springer Book Archive