Abstract
The F(ab′)2 fragments were prepared from three monoclonal antibodies (MAbs) reactive with either peplomer glycoprotein (E2) or nucleocapsid protein (NP) of a low-virulence mouse hepatitis virus (MHV), MHV-NuU. All the three MAbs could protect mice from challenge infection with virulent MHV-2, whereas only one of the anti-E2 MAbs was capable of neutralizing the virus in vitro. The F(ab′)2 fragment of neutralizing anti-E2 MAb was shown to protect mice from challenge infection, but those of non-neutralizing anti-E2 and anti-NP MAbs were not protective.
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Keywords
- Nucleocapsid Protein
- Challenge Infection
- Mouse Hepatitis Virus
- Viral Nucleocapsid Protein
- Virus Neutralize Titer
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© 1987 Plenum Press, New York
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Nakanaga, K., Yamanouchi, K., Fujiwara, K. (1987). Protective Effect of the F(ab′)2 Fragments of Monoclonal Antibodies to Mouse Hepatitis Virus. In: Lai, M.M.C., Stohlman, S.A. (eds) Coronaviruses. Advances in Experimental Medicine and Biology, vol 218. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1280-2_45
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DOI: https://doi.org/10.1007/978-1-4684-1280-2_45
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