Abstract
Murine coronavirus (MHV) infections of continuous cell lines show a wide spectrum of cell-virus interactions. Cell lines have been identified that can be lytically infected, persistently infected, or non-infectable (1, 2, 3). At present the mechanisms involved in determining the outcome of the infectious process are not clearly understood. In previous work a cell line, the rat C6 glial line, was identified that was resistant to infection by both the MHV3 and JHM strains of MHV (1). Studies have been initiated to examine the reasons for this restriction in order to understand mechanisms whereby cells can be refractory to coronavirus infections and to understand the replication strategy of these agents.
Chapter PDF
Similar content being viewed by others
Keywords
- Infectious Virus
- Vesicular Stomatitis Virus
- Replication Strategy
- Continuous Cell Line
- Coronavirus Infection
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Lucas, A., Coulter, M., Anderson, R., Dales, S., and Flintoff, tW. (1978). In vivo and in vitro models of demyelinating diseases. II. Persistence and host-regulated thermosensitivity in cells of neural derivation infected with mouse hepatitis and measles viruses. Virology 88, 325–337.
Siddell, S., Wege, H., and ter Meulen, V. (1982). The structure and replication of coronaviruses. Cur. Top. Microbiol. Immunol. 99, 131–163.
Sturman, L., and Holmes, K. (1983). The molecular biology of coronaviruses. Adv. Virus Res. 28, 35–112.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Plenum Press, New York
About this chapter
Cite this chapter
Flintoff, W.F., Van Dinter, S. (1987). A Cell Line Defective in Murine Coronavirus Internalization. In: Lai, M.M.C., Stohlman, S.A. (eds) Coronaviruses. Advances in Experimental Medicine and Biology, vol 218. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1280-2_34
Download citation
DOI: https://doi.org/10.1007/978-1-4684-1280-2_34
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-1282-6
Online ISBN: 978-1-4684-1280-2
eBook Packages: Springer Book Archive