Abstract
The spike protein of IBV is a target for virus neutralising antibodies in the chicken (Cavanagh et al, 1984; Mockett, 1985). Vaccinia virus, a poxvirus, has been shown to be a useful and efficient eukaryotic expression vector. Here we describe the expression of the IBV spike from a cDNA clone inserted into vaccinia virus and demonstrate that mice vaccinated with the recombinant produce antibodies to the spike which can neutralise virus infectivity.
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References
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© 1987 Plenum Press, New York
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Tomley, F., Binns, M., Boursnell, M., Mockett, A. (1987). Expression of IBV Spike Protein by a Vaccinia Virus Recombinant. In: Lai, M.M.C., Stohlman, S.A. (eds) Coronaviruses. Advances in Experimental Medicine and Biology, vol 218. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1280-2_17
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DOI: https://doi.org/10.1007/978-1-4684-1280-2_17
Publisher Name: Springer, Boston, MA
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