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The Role of LCAT and Cholesteryl Ester Transfer Proteins for the HDL and LDL Structure and Metabolism

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Lipoproteins and Atherosclerosis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 210))

Abstract

Lecithins: cholesterol acyl transferase (LCAT) is an enzyme of man and many animal species which catalyzes the formation of cholesteryl esters (CE) in plasma. Glomset(l) was first to describe in 1962 that phosphatidyl choline (lecithin) and free cholesterol (FC) are involved in this reactions LCAT transfers the fatty acid of position -2 of lecithin to the -OH group of free cholesterol yielding in lysolecithin and CE.

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References

  1. J.A. Glomset and J.L. Wright, Some properties of a cholesterol esterifying enzyme in human plasma, Biochim. Biophys. Acta 89: 266 (1964).

    PubMed  CAS  Google Scholar 

  2. J.A. Glomset, An exercise in comparative biology. In: Progr. Biochem. Pharmacol. S. Eisenberg ed, Karger Basel (1979) 41pp.

    Google Scholar 

  3. M. Dobiasova, Lecithins cholesterol acyltransferase and the regulation of endogenous cholesterol transport, Adv-Lipid Res. 20: 107 (1983).

    PubMed  CAS  Google Scholar 

  4. G.M. Kostner, LCAT and the cholesterol transfer, Proc. of the IVth. Dresdener Lipid Symposium, VEB Dresden (1982) 640.

    Google Scholar 

  5. J. Kostner, Studies on the cofactor requirements of LCAT, Scand. J. Clin. Lab. Invest. 33,Suppl.137: 19 (1974).

    CAS  Google Scholar 

  6. H. Dieplinger and G.M. Kostner, The determination of LCAT. Ins Handbook of Electrophoresis, L.A. Lewis, J.J. Opplt eds CRC press N.Y., (1983) 57pp.

    Google Scholar 

  7. P.J. Barter, G.J. Hopkins, G.D. Calvert and Y.C. Ha, A model of plasma esterified cholesterol metabolism: The role of esterified cholesterol transfer and exchanges between plasma lipoproteins, In: Lipoprotein Kinetics and Modeling, Acad. Press N.Y.,(1982) 351pp.

    Google Scholar 

  8. D.B. Zilversmit, Lipid transfer proteinss Overview and applications, Methods in Enzymology 98: 565 (1983).

    Article  PubMed  CAS  Google Scholar 

  9. Y.C. Ha, and P.J. Barter, Differences in plasma cholesteryl ester transfer activity in sixteen vertebrate species, Comp. Biochem, Physiol. 71B: 265 (1982).

    CAS  Google Scholar 

  10. R.L. Hamilton, M.C. Williams, C.J. Fielding and R.J. Havel, Discoidal bilayer structure of nascent HDL from perfused rat liver, J. Clin. Invest. 58: 667 (1976).

    Article  PubMed  CAS  Google Scholar 

  11. J.A. Glomset, K.R. Norurn, E. Gjone, Plasma lipoproteins in familial LCAT deficiency: Effects of dietary manipulations, Scand. J. Clin. Lab, Invest. 35,Suppl.142: 3 (1975).

    CAS  Google Scholar 

  12. A.V. Nichols, E.L. Gong and P.J. Blanche, Interconversion of HDL during incubation of human plasma, Biochim. Biophys. Res. Commun. 100: 391 (1981).

    Article  CAS  Google Scholar 

  13. J.R. Patsch, A.M. Botto, T. Olivecrona and S. Eisenberg, Formation of HDL-like particles during lipolysis of VLDL in vitro. Proc. Natl. Acad. Sci. USA 75: 4519 (1978).

    Article  PubMed  CAS  Google Scholar 

  14. H. Dieplinger, R. Zechner and G.M. Kostner, The in vitro formation of HDL-2 during the action of LCAT: the role of triglyceride rich lipoproteins, J. Lipid Res. 26: 273 (1985).

    PubMed  CAS  Google Scholar 

  15. G. Knipping, R. Zechner, G.M. Kostner and A. Holasek, Factors affecting the conversion of HDL: experiments with pig and human plasma, Biochim. Biophys. Acta 835: 244 (1985).

    PubMed  CAS  Google Scholar 

  16. G.M. Kostner, The influence of various lipoproteins and apo-lipoproteins on the in vitro esterification of cholesterol in human serum by the enzyme LCAT, Scand.J. Cl in. Lab. Invest. 38,Suppl. 150: 66 (1978).

    Article  CAS  Google Scholar 

  17. R. Zechner, H. Dieplinger, A. Roscher and G.M. Kostner, The LDL pathway of native and chemically modified LDL isolated from plasma incubated in vitro, Biochem. J. 224: 569 (1984).

    PubMed  CAS  Google Scholar 

  18. G.M. Kostner, F. Krempler, H. Dieplinger, R. Zechner, I. Teubl and F. Sandhofer, Alterd metabolism of low density lipoprotein in humans after prolonged incubation in plasma, Clin. Sci. 68: 411 (1985).

    PubMed  CAS  Google Scholar 

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© 1987 Plenum Press, New York

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Kostner, G.M., Knipping, G., Groener, J.E.M., Zechner, R., Dieplinger, H. (1987). The Role of LCAT and Cholesteryl Ester Transfer Proteins for the HDL and LDL Structure and Metabolism. In: Malmendier, C.L., Alaupovic, P. (eds) Lipoproteins and Atherosclerosis. Advances in Experimental Medicine and Biology, vol 210. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1268-0_12

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  • DOI: https://doi.org/10.1007/978-1-4684-1268-0_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1270-3

  • Online ISBN: 978-1-4684-1268-0

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