A Family Study of Hypoalphalipoproteinemia

  • C. Vergani
  • A. L. Catapano
  • A. Sidoli
Part of the Advances in Experimetal Medicine and Biology book series (AEMB, volume 201)


In recent years the inverse relationship between HDL cholesterol and the risk of coronary artery disease (CAD) has been supported by a lot of clinical and epidemiological data (1,2).


High Density Lipoprotein Chole Sterol Acyltransferase High Density Lipoprotein Level Tangier Disease High Density Lipoprotein Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    G.J. Miller and N.F. Miller. Plasma high density lipoprotein concentration and development of ischaemic heart disease. Lancet 1:16–20(1975)PubMedCrossRefGoogle Scholar
  2. 2.
    T. Gordon, W. P. Castelli, M. C. Hjortland, W.B. Kannel, and T.R. Dawber. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med, 62:707–14(1977).PubMedCrossRefGoogle Scholar
  3. 3.
    J. A. Glomset. The plasma lecithin; cholesterol acyltransferase reaction. J Lipid Res 9:155–67 (1968).PubMedGoogle Scholar
  4. 4.
    C. Vergani, A. C. Plancher, M. Zuin et al. Bile lipid composition and haemostatic variables in a case of high density lipoprotein deficiency (Tangier disease), Eur J Clin Invest 14:49–54 (1984).PubMedCrossRefGoogle Scholar
  5. 5.
    N.E. Miller, A. La Ville, and D. Crook. Direct evidence that reverse cholesterol transport is mediated by high-density lipoprotein in rabbit, Nature 314:109–11 (1985).PubMedCrossRefGoogle Scholar
  6. 6.
    A. Heiberg. The heritability of serum lipoprotein and lipid concentrations. A twin study. Clin Genet 6:307–16 (1974).Google Scholar
  7. 7.
    H. Micheli, D. Pometta, and C. Jornot. High density lipoprotein cholesterol in male relatives of patients with coronary heart disease, Atherosclerosis 32:269–76 (1979).PubMedCrossRefGoogle Scholar
  8. 8.
    M. S. Nupuf and W. H. F. Sutherland. High density lipoprotein levels in children of young men with ischaemic heart disease. Atherosclerosis 33:365–70 (1979).PubMedCrossRefGoogle Scholar
  9. 9.
    S.W. Law, G. Gray, H. B. Jr. Brewer, A. Sakaguchi and S. Naylor. Human apolipoprotein A-I and C-III genes reside in pll-ql3 region of chromosome 11. Biochem Biophys Res Commun 118:934–42(1984).PubMedCrossRefGoogle Scholar
  10. 10.
    T.J. Knott, R.L. Eddy, M.E. Robertson, L.M. Priestley, J. Scott and T.B. Schows. Chromosomal localization of the human apoprotein CI gene and of a polymorphic apoprotein AII gene, Biochem BiophysRes Commun 125:299–305 (1984).CrossRefGoogle Scholar
  11. 11.
    R.A. Norum, J.B. Lakier, S. Goldstein et al. Familial deficiency of apolipoproteins A-I and C-III and precocious coronary-artery disease, N Engl J Med 306:1513–9 (1982).PubMedCrossRefGoogle Scholar
  12. 12.
    C. Vergani and G. Bettale. Familial hypo-alpha-lipoproteinemia. Clin Chim Acta 114:45–52 (1981).PubMedCrossRefGoogle Scholar
  13. 13.
    E. J. Schaefer. Clinical, biochemical and genetic features in familial disorders of high density lipoprotein deficiency. Arteriosclerosis 4:303–22 (1984).PubMedCrossRefGoogle Scholar
  14. 14.
    J. L. Third, J. Montag, M. Flynn, J. Freidel, P. Laskarzewski and C. J. Gluek. Primary and familial high density lipoproteins: their metabolic properties and response to drug therapy. Biochim Biophys Acta, 751:175–88 (1983).CrossRefGoogle Scholar
  15. 15.
    A. Sidoli, G. Giudici, M. Soria and C. Vergani. RFLP haplotype in the AI-CIII gene complex occurring in a family with hypoalphalipo-proteinemia. In press.Google Scholar
  16. 16.
    J. Scott, T.J. Knott, L. M. Priestley, M.E. Robertson, D.V. Mann, G. Kostner, G.J. Miller and N.E. Miller. High-density lipoprotein composition is altered by a common DNA polymorphism adjacent to apoprotein All gene in man, Lancet 1:771–3 (1985).PubMedCrossRefGoogle Scholar
  17. 17.
    C.H. Breier, V. Mühlberger, E. Knapp et al. Apolipoprotein All and coronary artery disease, Lancet 1:1339 (1985).PubMedCrossRefGoogle Scholar
  18. 18.
    S. Eisenberg. High density lipoprotein metabolism. J Lipid, Res. 25:1017–58 (1984).Google Scholar
  19. 19.
    J. M. Ordovas, E.J. Schaefer, D. Salem et al. Apolipoprotein A-I gene polymorphism in the 3’ flanking region associated with familial hypoalphalipoproteinemia and premature coronary artery disease. In press.Google Scholar
  20. 20.
    R.M. Krauss. Regulation of high density lipoprotein levels. Med Clin, N Am 66: 403–30 (1982).Google Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • C. Vergani
    • 1
  • A. L. Catapano
    • 2
  • A. Sidoli
    • 3
  1. 1.Third Department of Clinical MedicineUniversity of MilanItaly
  2. 2.Institute of Pharmacology and PharmacognosyUniversity of MilanItaly
  3. 3.Laboratory of Molecular BiologyFarmitalia Carlo Erba MilanItaly

Personalised recommendations