Advertisement

Familial Hypoalphalipoproteinemia

  • Charles J. Glueck
  • Marc A. Melser
  • I. B. Borecki
  • Jane L. H. C. Third
  • D. C. Rao
  • Peter M. Laskarzewski
Part of the Advances in Experimetal Medicine and Biology book series (AEMB, volume 201)

Abstract

Primary hypoalphalipoproteinemia, characterized by primary depression of high density lipoprotein cholesterol (HDL-C) levels below the age-sex-race-specific 10th percentile (in the absence of other abnormalities of lipoprotein cholesterols), is closely associated with premature atherosclerotic coronary heart. disease, rayocardial infarction, and ischemic cerebrovascular disease.1–4 These premature coronary and cerebrovascular events usually occur in the primary hypoalphalipoproteinemic subjects at young ages, often before age 55, in keeping with the significant inverse association of HDL-C with coronary heart disease (CHD) in population groups.5,6 Primary depression of HDL-C and/or apolipoprotein Al (apo Al) is a valuable marker in identifying individuals at accelerated risk for premature atherosclerosis.1–6

Keywords

High Density Lipoprotein Cholesterol Degree Relative Segregation Analysis Plasma High Density Lipoprotein Cholesterol Complex Segregation Analysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    J.L.H.C. Third, J. Montag, M. Flynn, J. Freidel, P. Laskarzewski, and C.J. Glueck, Primary and familial hypoalphaliporoteinemia. Metabolism 3:16–146, 1984.Google Scholar
  2. 2.
    C.J. Glueck, P. Laskarzewski, D.C. Rao, and J.A. Morrison, Familial aggregations of coronary risk, in “Complications in Coronary Heart Disease”, edited by Connor W and Bristow D, Lippincott Co., 1985, pp 173-193.Google Scholar
  3. 3.
    S.R. Daniels, S. Bates, R. Lukin, C. Benton, J.H.L.C. Third, and C.J. Glueck, Cerebrovascular arteriopathy (arteriosclerosis) and ischemic childhood stroke. Stroke 1:360–365, 1982.CrossRefGoogle Scholar
  4. 4.
    M.J. Malloy and J.P. Kane, Hypolipidemia. Med. Clin. N. Amer. 66:469–484, 1982.PubMedGoogle Scholar
  5. 5.
    W.P. Castelli, J.T. Doyle, T. Gordon, C.J. Hames, M.C. Hjortland, S.B. Hulley, A. Kagan, and W.J. Zuigi, HDL cholesterol and other lipids in coronary heart disease. The cooperative lipoprotein phenotyping study. Circulation 55:767–772, 1977.PubMedCrossRefGoogle Scholar
  6. 6.
    G. Heiss, N.J. Johnson, S. Reiland, C.G. Davis, and H.A. Tyroler, The epidemiology of plasma high density lipoprotein cholesterol levels. Circulation 62 (suppl. IV):116–136, 1980.Google Scholar
  7. 7.
    D.C. Rao, P.M. Laskarzewski, J.A. Morrison, P. Khoury, K. Kelly, R. Wette, J. Russell, and C.J. Glueck, The Cincinnati Lipid Research Clinic Family Study: Cultural and biological determinants of lipids and lipoprotein concentrations. Am. J. Hum. Genet. 34:888–903, 1982.PubMedGoogle Scholar
  8. 8.
    C. Vergani and G. Bettale, Familial hypo-alpha-lipoproteinemia. Clin. Chim. Acta 114:45–52, 1981.PubMedCrossRefGoogle Scholar
  9. 9.
    P.J. Byard, I.B. Borecki, C.J. Glueck, P.M. Laskarzewski, J.L.H.C. Third, and D.C. Rao, A genetic study of hypoalphalipoproteinemia. Genetic Epidemiology 1:43–51, 1984.PubMedCrossRefGoogle Scholar
  10. 10.
    J. Third and C.J. Glueck, Normotriglyceridemic primary and familial hypoalphalipoproteinemia and coronary heart disease. Circulation 68(4):756, 1983; Arteriosclerosis 3(5):A486, 1983. Presented at the 56th Scientific Session of the American Heart Association Nov., 1983.CrossRefGoogle Scholar
  11. 11.
    I.B. Borecki, D.C. Rao, J.H.L.C. Third, P. Laskarzewski, and C.J. Glueck, A major gene for primary hypoalphalipoproteinemia. Am. J. Hum. Genet, in review, 1985.Google Scholar
  12. 12.
    L.H. Myers, N.R. Phillip, and R.J. Havel, Mathematical evaluation of methods for estimation of the concentration of the major lipid components of human lipoproteins. J. Lab. Clin. Med. 88:491–505, 1976.PubMedGoogle Scholar
  13. 13.
    J.A. Morrison, P. Khoury, P.M. Laskarzewski, M.J. Mellies, K. Kelly, and C.J. Glueck, Intrafamilial association of lipids and lipoproteins in kindreds with hypertriglyceridemic probands: The Princeton School Family Study. Circulation 66:67–76, 1982.PubMedCrossRefGoogle Scholar
  14. 14.
    P.O Kwiterovich, D.S. Fredrickson, and R.I. Levy, Familial hypercho-lesterolemia (one form of familial type II hyperlipoproteinemia). J. Clin. Invest. 53:1237–1249, 1974.PubMedCrossRefGoogle Scholar
  15. 15.
    C.J. Glueck, Influence of Gemifbrozil on high-density lipoproteins. Am. J. Cardiology, 52(4):31B–35B, 1983.CrossRefGoogle Scholar
  16. 16.
    J. Marks, Dyslipoproteinaemia — Aspects of Gemfibrozil. Research and Clinical Forums. 4(#2):5–133, 1982.Google Scholar
  17. 17.
    C.B. Laurell, Electroimmunoassay of apolipoprotein Al usng high titer monospecific antibodies. Scand. J. Clin. Lab. Inv. 29(Suppl. 124):21, 1972.CrossRefGoogle Scholar
  18. 18.
    G. Schonfeld, J.S. Chen, W.F. McDonnel, and I. Jeng, Apolipoprotein-A-II content of human plasma and high density lipoprotens measured by radioimmunoassay. J. Lipid Res. 18:645–655, 1977.PubMedGoogle Scholar
  19. 19.
    T. Gordon and W.B. Cannel, Multiple risk factors for predicting coronary heart disease. The concpt, accuracy, and application. Am. Heart J. 103:1031–1039, 1982.PubMedCrossRefGoogle Scholar
  20. 20.
    J. M. Lalouel, D.C. Rao, N.E. Morton, and R.C. Elston, A unified model for complex segregation analysis. Am. J. Hum. Genet. 35:816–826, 1983.PubMedGoogle Scholar
  21. 21.
    J.M. Lalouel and N.E. Morton, Complex segregation analysis with pointers. Hum. Heret. 31:312–321, 1981.CrossRefGoogle Scholar
  22. 22.
    N.E. Morton, D.C. Rao, and J.M. Lalouel, Methods in Genetic Epidemiology. Basel, Switzerland; S. Karger, 1983.Google Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Charles J. Glueck
    • 1
  • Marc A. Melser
    • 1
  • I. B. Borecki
    • 2
  • Jane L. H. C. Third
    • 1
  • D. C. Rao
    • 2
  • Peter M. Laskarzewski
    • 1
  1. 1.Lipid Research Clinic, General Clinical Research Center, and CLINFO Centers, Departments of Medicine and Pediatrics, Lipid Research DivisionUniversity of Cincinnati Medical CenterCincinnatiUSA
  2. 2.Divisions of Biostatistics, Department of Preventive Medicine, Psychiatry, and GeneticsWashington University School of MedicineSt. LouisUSA

Personalised recommendations