Familial Hypoalphalipoproteinemia

  • Charles J. Glueck
  • Marc A. Melser
  • I. B. Borecki
  • Jane L. H. C. Third
  • D. C. Rao
  • Peter M. Laskarzewski
Part of the Advances in Experimetal Medicine and Biology book series (AEMB, volume 201)


Primary hypoalphalipoproteinemia, characterized by primary depression of high density lipoprotein cholesterol (HDL-C) levels below the age-sex-race-specific 10th percentile (in the absence of other abnormalities of lipoprotein cholesterols), is closely associated with premature atherosclerotic coronary heart. disease, rayocardial infarction, and ischemic cerebrovascular disease.1–4 These premature coronary and cerebrovascular events usually occur in the primary hypoalphalipoproteinemic subjects at young ages, often before age 55, in keeping with the significant inverse association of HDL-C with coronary heart disease (CHD) in population groups.5,6 Primary depression of HDL-C and/or apolipoprotein Al (apo Al) is a valuable marker in identifying individuals at accelerated risk for premature atherosclerosis.1–6


High Density Lipoprotein Cholesterol Degree Relative Segregation Analysis Plasma High Density Lipoprotein Cholesterol Complex Segregation Analysis 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Charles J. Glueck
    • 1
  • Marc A. Melser
    • 1
  • I. B. Borecki
    • 2
  • Jane L. H. C. Third
    • 1
  • D. C. Rao
    • 2
  • Peter M. Laskarzewski
    • 1
  1. 1.Lipid Research Clinic, General Clinical Research Center, and CLINFO Centers, Departments of Medicine and Pediatrics, Lipid Research DivisionUniversity of Cincinnati Medical CenterCincinnatiUSA
  2. 2.Divisions of Biostatistics, Department of Preventive Medicine, Psychiatry, and GeneticsWashington University School of MedicineSt. LouisUSA

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