HDL Binding to Human Adipocyte Plasma Membranes: Regional Variation in Omental and Subcutaneous Depots

  • Bessie Fong
  • Andrew Salter
  • Jose Jimenez
  • Jean-Pierre Despres
  • Aubie Angel
Part of the Advances in Experimetal Medicine and Biology book series (AEMB, volume 201)


Human adipose tissue contains one of the largest pools of exchangeable cholesterol in the body, accounting for about 25 percent of total body cholesterol in normal man (1,2). This adipose cholesterol pool is much expanded in obesity and in the massively obese state, well over half of total body cholesterol can be found in the fat tissue (1,2). Obesity is also commonly associated with a number of lipoprotein abnormalities. Increased synthesis and/or turnover of LDL (3) and VLDL (4,5) have been reported. In addition, HDL-cholesterol in plasma is significantly reduced (6–13) and has been attributed primarily to a decrease in the HDL2 subfraction (7).


Human Adipose Tissue Subcutaneous Depot HDL2 Subfraction Adipose Tissue Biopsy Cellular Cholesterol Content 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Bessie Fong
    • 1
  • Andrew Salter
    • 1
  • Jose Jimenez
    • 1
  • Jean-Pierre Despres
    • 1
  • Aubie Angel
    • 1
  1. 1.Department of Medicine and Institute of Medical ScienceUniversity of Toronto and Division of Endocrinology and Metabolism, Toronto General HospitalTorontoCanada

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