Advertisement

HDL Binding to Human Adipocyte Plasma Membranes: Regional Variation in Omental and Subcutaneous Depots

  • Bessie Fong
  • Andrew Salter
  • Jose Jimenez
  • Jean-Pierre Despres
  • Aubie Angel
Chapter
Part of the Advances in Experimetal Medicine and Biology book series (AEMB, volume 201)

Abstract

Human adipose tissue contains one of the largest pools of exchangeable cholesterol in the body, accounting for about 25 percent of total body cholesterol in normal man (1,2). This adipose cholesterol pool is much expanded in obesity and in the massively obese state, well over half of total body cholesterol can be found in the fat tissue (1,2). Obesity is also commonly associated with a number of lipoprotein abnormalities. Increased synthesis and/or turnover of LDL (3) and VLDL (4,5) have been reported. In addition, HDL-cholesterol in plasma is significantly reduced (6–13) and has been attributed primarily to a decrease in the HDL2 subfraction (7).

Keywords

Human Adipose Tissue Subcutaneous Depot HDL2 Subfraction Adipose Tissue Biopsy Cellular Cholesterol Content 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Angel, A. and G.A. Bray. 1979. Eur. J. Clin. Invest. 9:355–362PubMedCrossRefGoogle Scholar
  2. 2.
    Schreibman, P.H. and R.B. Dell. 1975. J. Clin. Invest. 55:986–993PubMedCrossRefGoogle Scholar
  3. 3.
    Kesaniemi, Y.A. and S.M. Grundy. 1983. Arteriosclerosis 3:170–177PubMedCrossRefGoogle Scholar
  4. 4.
    Nestel, P.J. and H. M. Whyte. 1968. Metabolism 17:1122–1128PubMedCrossRefGoogle Scholar
  5. 5.
    Nestel, P. and B. Goldrick. 1976. Clin. Endocrinol. Metabol. 55:313–335CrossRefGoogle Scholar
  6. 6.
    Carlson, L.A. and M. Ericsson. 1975. Atherosclerosis 21:417–433PubMedCrossRefGoogle Scholar
  7. 7.
    Albrink, M.J., R.M. Krauss and F.T. Lindgren. 1980. Lipids 15:668–676PubMedCrossRefGoogle Scholar
  8. 8.
    Phillips, N.R., R.J. Havel and J.P. Kane. 1981. Arteriosclerosis 1:13–24PubMedCrossRefGoogle Scholar
  9. 9.
    Rossner, S. and D. Halberg. 1978. Acta Med. Scand. 204:103–110PubMedCrossRefGoogle Scholar
  10. 10.
    Contaldo, F., P. Strazzullo and A. Postiglione. 1980. Atherosclerosis 37:163–167PubMedCrossRefGoogle Scholar
  11. 11.
    Matter, S., A. Weltman and B.A. Stamford. 1980. J. AM. Diet Assoc. 77:149–152PubMedGoogle Scholar
  12. 12.
    Berchtold, P., M. Berger and V. Jorgens. 1981. Int. J. Obesity 5:1–10Google Scholar
  13. 13.
    Wechsler, J.G., V. Hutt and H. Wenzel. 1981. Int. J. Obesity 5:325–331Google Scholar
  14. 14.
    Fong, B.S., P.O. Rodrigues and A. Angel. 1984. J. Biol. Chem. 259:10168–10174PubMedGoogle Scholar
  15. 15.
    Fong, B.S., P.O. Rodrigues, A.M. Salter, B.P. Yip, J.P. Despres, R.E. Gregg and A. Angel. 1985. J. Clin. Invest. 75:1804–1812PubMedCrossRefGoogle Scholar
  16. 16.
    Rodbell, M. 1964. J. Biol. Chem. 239:375–380PubMedGoogle Scholar
  17. 17.
    Despres, J.P., C. Bouchard, A. Tremblay, R. Savard and M. Marcotte. 1985. Med. Sci. Sports and Exercise 17:113–118Google Scholar
  18. 18.
    Gurr, M.I., R.T. Jung, M.P. Robinson and W.P.T. James. 1982. Int. J. Obesity 6:419–436Google Scholar
  19. 19.
    Livingston, J.N., K.M. Lerea, J. Bolinder, L. Kager, L. Backman and P. Amer. 1984. Diabetologia 27:447–453PubMedCrossRefGoogle Scholar
  20. 20.
    McKeel, D.W. and L. Jarett. 1970. J. Cell Biol. 44:417–432PubMedCrossRefGoogle Scholar
  21. 21.
    Havel, R.J., H. Eder and H.F. Bragden. 1955. J. Clin. Invest. 34:1345–1353PubMedCrossRefGoogle Scholar
  22. 22.
    Shepherd, J., D.K. Bedford, H.G. Morgan and E. Scott. 1976. Clin. Chim. Acta 66:97–109PubMedCrossRefGoogle Scholar
  23. 23.
    Bolinder, J., L. Kager, J. Ostman and P. Arner. 1983. Diabetes 32:117–123PubMedCrossRefGoogle Scholar
  24. 24.
    Ostman, J., P. Arner, P. Engfeldt and L. Kager. 1979. Metabolism 28:1198–1205PubMedCrossRefGoogle Scholar
  25. 25.
    Lithell, H. and J. Boberg. 1978. Int. J. Obesity 2:47–52Google Scholar
  26. 26.
    Rebuffe-Scrive, M., L. Enk, N. Crona, P. Lonnroth, L. Abrahamsson, V. Smith and P. Bjorntorp. 1985. J. Clin. Invest. 75:1973–1976PubMedCrossRefGoogle Scholar
  27. 27.
    Oram, J.F., E.A. Brinton and E.L. Bierman. 1983. J. Clin. Invest. 72:1611–1621PubMedCrossRefGoogle Scholar
  28. 28.
    Lohman, T.G. 1981. Hum. Biol. 53:181–225PubMedGoogle Scholar
  29. 29.
    Despres, J.P., C. Allard, A. Tremblay, J. Talbot and C. Bouchard. 1985. Metabolism 34:967–973PubMedCrossRefGoogle Scholar
  30. 30.
    Wolf, R.N. and S.M. Grundy. 1983. Arteriosclerosis 3:160–169PubMedCrossRefGoogle Scholar
  31. 31.
    Gonen, B., J.D. Halverson and G. Schonfeld. 1983. Metabolism 32:492–496PubMedCrossRefGoogle Scholar
  32. 32.
    Zimmerman, J., N.A. Kaufman, M. Fainaru, S. Eisenberg, Y. Oschry, Y. Friedlander and Y. Steion. 1984. Arteriosclerosis 2:15–123Google Scholar
  33. 33.
    Sorbis, R., B.G. Petersson and P. Nilsson-Ehle. 1981. Eur. J. Clin. Invest. 11:491–498CrossRefGoogle Scholar
  34. 34.
    Friedman, C.I., J.M. Falko, S.T. Patel, M.H. Kim, H.A.I. Newman and H. Barrows. 1982. J. Clin. Endocrinol. Metabl. 55:258–262CrossRefGoogle Scholar
  35. 35.
    Kissebah, A.H., N. Vydelingum, R. Murray, D.J. Evans, A.J. Hartz, R.K. Kalkhoff and P.W. Adams. 1982. J. Clin. Endocrinol. Metab. 54:254–260PubMedCrossRefGoogle Scholar
  36. 36.
    Larsson, B., K. Svardsudd, L. Welin, L. Wilhelmsen, P. Bjorntorp and G. Tibblin. 1984. Brit. Med. J. 288:1401–1404CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Bessie Fong
    • 1
  • Andrew Salter
    • 1
  • Jose Jimenez
    • 1
  • Jean-Pierre Despres
    • 1
  • Aubie Angel
    • 1
  1. 1.Department of Medicine and Institute of Medical ScienceUniversity of Toronto and Division of Endocrinology and Metabolism, Toronto General HospitalTorontoCanada

Personalised recommendations