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The Apo E-System: Genetic Control of Plasma Lipoprotein Concentration

  • Gerd Utermann
Part of the Advances in Experimetal Medicine and Biology book series (AEMB, volume 201)

Abstract

Apolipoprotein E from human plasma is a glycoprotein composed of 299 amino acids of known sequence 1 that is synthezised in the liver and in several peripheral tissues of the body2–3. In plasma apo E is present on different lipoprotein particles. It is a constituent of plasma chylomicrons that carry exogenous lipids and of their catabolic products called remnants that are generated from chylomicrons by hydrolysis of core triglycerides through the action of lipoprotein lipase (LPL). Such remnants are not present in the plasma of healthy fasting humans since they are rapidly taken up by the liver through receptor mediated endocytosis (Fig. 1). The ligand on the surface of chylomicrons that is recognized by the remnant-receptor on liver cells is apo E5.

Keywords

Human Apolipoprotein Elevated Plasma Cholesterol Binding Defect Plasma Lipoprotein Concentration Core Triglyceride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Gerd Utermann
    • 1
  1. 1.Institut für Medizinische Biologie und GenetikUniversität InnsbruckInnsbruckAustria

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