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The Apo E-System: Genetic Control of Plasma Lipoprotein Concentration

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Lipoprotein Deficiency Syndromes

Part of the book series: Advances in Experimetal Medicine and Biology ((AEMB,volume 201))

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Abstract

Apolipoprotein E from human plasma is a glycoprotein composed of 299 amino acids of known sequence 1 that is synthezised in the liver and in several peripheral tissues of the body2–3. In plasma apo E is present on different lipoprotein particles. It is a constituent of plasma chylomicrons that carry exogenous lipids and of their catabolic products called remnants that are generated from chylomicrons by hydrolysis of core triglycerides through the action of lipoprotein lipase (LPL). Such remnants are not present in the plasma of healthy fasting humans since they are rapidly taken up by the liver through receptor mediated endocytosis (Fig. 1). The ligand on the surface of chylomicrons that is recognized by the remnant-receptor on liver cells is apo E5.

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Author information

Authors and Affiliations

  1. Institut für Medizinische Biologie und Genetik, Universität Innsbruck, Schöpfstrasse 41, A-6020, Innsbruck, Austria

    Gerd Utermann

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  1. Gerd Utermann
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Editor information

Editors and Affiliations

  1. Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada

    Aubie Angel

  2. Shaughnessy Hospital, University of British Columbia, Vancouver, British Columbia, Canada

    Jiri Frohlich

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© 1986 Springer Science+Business Media New York

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Utermann, G. (1986). The Apo E-System: Genetic Control of Plasma Lipoprotein Concentration. In: Angel, A., Frohlich, J. (eds) Lipoprotein Deficiency Syndromes. Advances in Experimetal Medicine and Biology, vol 201. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1262-8_23

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  • DOI: https://doi.org/10.1007/978-1-4684-1262-8_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1264-2

  • Online ISBN: 978-1-4684-1262-8

  • eBook Packages: Springer Book Archive

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