Inhibition and Activation of Cholesteryl Ester Transfer and its Significance in Plasma Cholesterol Metabolism
Cholesteryl ester transfer in plasma can be defined as the catalyzed movement of preformed cholesteryl ester between lipoprotein particles. In mammalian plasma, this activity resides in one or more of a class of transfer proteins which show specificity for hydrophobic lipids such as cholesteryl and retinyl esters and triglycerides.1–3 It has been suggested that the mechanism of catalysis is in the ability of such transfer proteins to increase the solubility of these lipids in plasma and in that way increase diffusion rates between lipid surfaces.4 Alternatively, the transfer protein may facilitate complex formation between donor and acceptor lipoprotein particles.5 Studies using labeled cholesteryl esters and triglycerides indicate that transfer is bidirectional.6 However, the effective concentration of these lipids in different lipoproteins in usually not the same; as a result, the forward and back rates of transfer will not be identical and a net transfer of cholesteryl ester will result.
KeywordsHigh Density Lipoprotein Cholesteryl Ester Transfer Protein Free Cholesterol Reverse Cholesterol Transport Cholesterol Acyltransferase
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