Cholesterol Efflux: Mechanism and Regulation

  • George H. Rothblat
  • Michael C. Phillips
Part of the Advances in Experimetal Medicine and Biology book series (AEMB, volume 201)


The removal of cholesterol from peripheral cells by HDL is the first step in what has become known as reverse cholesterol transport. This process involves the efflux of free cholesterol from the membrane of cells and the transport of the cholesterol to the liver1. This report will present data obtained from our studies on cholesterol efflux and then, briefly, discuss some related data on the mechanism of cholesterol uptake by the liver.


Cholesterol Efflux Hepatic Lipase Acceptor Concentration Cellular Cholesterol Unstirred Water Layer 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • George H. Rothblat
    • 1
  • Michael C. Phillips
    • 1
  1. 1.Department of Physiology and BiochemistryThe Medical College of PennsylvaniaPhiladelphiaUSA

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