Skip to main content

Lecithin: Cholesterol Acyltransferase, a Review and Immunochemical Studies

  • Chapter
Lipoprotein Deficiency Syndromes

Part of the book series: Advances in Experimetal Medicine and Biology ((AEMB,volume 201))

  • 194 Accesses

Abstract

Lecithin: cholesterol acyltransferase (LCAT; EC 2.3.1.43) is the major source of cholesteryl esters in human plasma1. Despite the considerable progress made in the characterization of this enzyme, the precise mechanism for the formation of cholesteryl esters and their distribution in the various plasma lipoproteins remains unknown and is still actively studied. We will summarize here some of the most recent investigations made in this area and describe some pertinent results from our laboratory.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Glomset J.A. and Norum K.R. (1973) Adv. Lipid Res. 11, 1–65.

    CAS  Google Scholar 

  2. Marcel Y.L. (1982) Adv. Lipid Res. 19, 85–135.

    Google Scholar 

  3. Rall S.C. Jr., Weisgraber K.H., Mahley R.W., Ogawa Y., Fielding C.J., Utermann G., Haas J., Steinmetz A., Menzel H.-J., and Assmann G. (1984) J. Biol. Chem. 259, 10063–10070.

    PubMed  CAS  Google Scholar 

  4. Utermann G., Haas J., Steinmetz A., Paetzold R., Rall S.C. Jr., Weisgraber K.H. and Mahley R.W. (1984) Eur. J. Biochem. 144, 325–331.

    Article  PubMed  CAS  Google Scholar 

  5. Sparrow J.T. and Gotto A.M. Jr. (1982) C.R.C. Crit. Rev. Biochem. 13, 87–107.

    Article  CAS  Google Scholar 

  6. Chen C.H. and Albers J.J. (1983) Biochim. Biophys. Acta 753, 40–46.

    Article  PubMed  CAS  Google Scholar 

  7. Soutar A.K., Garner C.W., Baker H.N., Sparrow J.T., Jackson R.L., Gotto A.M., and Smith L.C. (1975) Biochemistry 14, 3057–3064.

    Article  PubMed  CAS  Google Scholar 

  8. Albers J.J., Lin J.T. and Roberts G.P. (1979) Artery 5, 61–75.

    PubMed  CAS  Google Scholar 

  9. Jonas A., Sweeny S.A. and Herbert P.N. (1984) J. Biol. Chem. 259, 6369–6375.

    PubMed  CAS  Google Scholar 

  10. Steinmetz A. and Utermann G. (1984) J. Biol. Chem. 260, 2258–2264.

    Google Scholar 

  11. Furukawa Y. and Nishida T. (1979) J. Biol. Chem. 254, 7213–7219.

    PubMed  CAS  Google Scholar 

  12. Boguski M.S., Elshourbagy N., Taylor J.M. and Gordon J.I. (1984) Proc. Natl. Acad. Sci. U.S.A. 81, 5021–5025.

    Article  PubMed  CAS  Google Scholar 

  13. Scanu A.M., Lagocki P. and Chung J. (1980) Ann. N.Y. Acad. Sci. 348, 160–173.

    Article  PubMed  CAS  Google Scholar 

  14. Jahani M. and Lacko A.G. (1981) J. Lipid Res., 22, 1102–1110.

    PubMed  CAS  Google Scholar 

  15. Yamazaki, S., Mitsunaga T., Furukawa Y. and Nishida T. (1983) J. Biol. Chem. 258, 5847–5853.

    PubMed  CAS  Google Scholar 

  16. Chen C.-H. and Albers J.J. (1982) Biochem. Biophys. Res. Commun. 107, 1091–1096.

    Article  PubMed  CAS  Google Scholar 

  17. Fielding P.E. and Fielding C.J. (1980) Proc. Natl. Acad. Sci. U.S.A. 77, 3327–3330.

    Article  PubMed  CAS  Google Scholar 

  18. Cheung M.C. and Albers J.J. (1984) J. Biol. Chem. 259, 12201–12209.

    PubMed  CAS  Google Scholar 

  19. Havel R.J., Eder, H.A. and Bragdon J.H. (1955) J. Clin. Invest. 34, 1345–1353.

    Article  PubMed  CAS  Google Scholar 

  20. Morton, R.E. and Zilversmit D.B. (1981) Biochim. Biophys. Acta 663, 350–355.

    Article  PubMed  CAS  Google Scholar 

  21. Suzue, G., Vézina, C. and Marcel, Y.L. (1980) Can. J. Biochem. 58, 539–541.

    PubMed  CAS  Google Scholar 

  22. Chen C.H. and Albers J.J. (1982) J. Lipid Res. 23 680–691.

    PubMed  CAS  Google Scholar 

  23. Stokke K.J., and Norum K.R. (1971) Scand. J. Clin. Lab. Invest. 27, 21–27.

    Article  PubMed  CAS  Google Scholar 

  24. Pattnaik N.M., Montes A, Hughes L.B. and Zilversmit D.B. (1978) Biochim. Biophys. Acta 530, 428–438.

    Article  PubMed  CAS  Google Scholar 

  25. Milne R.W., Douste-Blazy Ph., Retegui L., and Marcel Y.L. (1981) J. Clin. Invest. 68, 111–117.

    Article  PubMed  CAS  Google Scholar 

  26. Milne R.W., Weech P.K., Blanchette L., Davignon J., Alaupovic P. and Marcel Y.L. (1983) J. Clin. Invest. 73 816–823.

    Article  Google Scholar 

  27. Chalon M.P., Milne R.W. and Vaerman J.P. (1979) Europ. J. Immunol. 9, 747–751.

    Article  CAS  Google Scholar 

  28. Mellman I.S. and Unkeless J.C. (1980) J. Exp. Med. 152, 1048–1069.

    Article  PubMed  CAS  Google Scholar 

  29. Marcel Y.L., Hogue M., Théolis R. Jr., and Milne R.W. (1982) J. Biol. Chem. 257, 13165–13168.

    PubMed  CAS  Google Scholar 

  30. O’Farrell P.H. (1975) J. Biol. Chem. 250, 4007–4021.

    PubMed  Google Scholar 

  31. Doi Y., and Nishida T. (1983) J. Biol. Chem. 258, 5840–5846.

    PubMed  CAS  Google Scholar 

  32. Gambert P., Lallemant C, Athias A. and Padieu P. (1982) Biochim. Biophys. Acta 213 1–9.

    Google Scholar 

  33. Weber K., and Osborne M. (1969) J. Biol. Chem. 244, 4406–4412.

    PubMed  CAS  Google Scholar 

  34. Lowry O.H., Rosebrough N.J., Farr A.L. and Randall R.J. (1951) J. Biol. Chem. 193, 265–275.

    PubMed  CAS  Google Scholar 

  35. Bensadoun A. and Weinstein D. (1976) Anal. Biochem. 70, 241–250.

    Article  PubMed  CAS  Google Scholar 

  36. Weech P.K., Camato R., Milne R.W. and Marcel Y.L. (1985) Manuscript submitted for publication.

    Google Scholar 

  37. Utermann G., Menzel, H.-J., Adler G., Dieker P. and Weber W. (1980) Eur. J. Biochem. 107, 225–241.

    Article  PubMed  CAS  Google Scholar 

  38. Albers J.J., Adolphson J.L. and Chen C.-H. (1981) J. Clin. Invest. 67, 141–148.

    Article  PubMed  CAS  Google Scholar 

  39. Chong K.S., Davidson L, Huttash R.G. and Lacko A.G. (1981) Arch. Biochem. Biophys. 211, 119–124.

    Article  PubMed  CAS  Google Scholar 

  40. McConathy W.J. and Alaupovic P. (1976) Biochemistry 15, 515–520.

    Article  PubMed  CAS  Google Scholar 

  41. Chajek T., and Fielding, C.J. (1978) Proc. Natl. Acad. Sci. USA 75, 3445–3449.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer Science+Business Media New York

About this chapter

Cite this chapter

Marcel, Y.L., Vézina, C.A., Weech, P.K., Tercé, F., Milne, R.W. (1986). Lecithin: Cholesterol Acyltransferase, a Review and Immunochemical Studies. In: Angel, A., Frohlich, J. (eds) Lipoprotein Deficiency Syndromes. Advances in Experimetal Medicine and Biology, vol 201. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1262-8_15

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-1262-8_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1264-2

  • Online ISBN: 978-1-4684-1262-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics