Apoprotein A-I and Lecithin: Cholesterol Acyltransferase in a Patient with Tangier Disease
Tangier disease is a rare autosomal recessive disorder characterized by a virtual absence, of high density lipoprotein (HDL) and an accumulation of cholesteryl esters in a number of peripheral tissues (1). The exact genetic defect has not yet been fully elucidated.
KeywordsHigh Density Lipoprotein Cholesteryl Ester Cholesteryl Ester Transfer Protein Reverse Cholesterol Transport Cholesterol Acyl Transferase
Unable to display preview. Download preview PDF.
- 1.Schaefer EJ (1984) Tangier disease and related disorders Atherosclerosis 4, 303–322.Google Scholar
- 2.Clifton-Bligh P, Nestel PJ Whyte HM (1972) Tangier disease: report of a case and studies on lipid metabolism N Engl J Med 286, 567–571.Google Scholar
- 3.Class C, Pittman RC, Civen M and Steinberg D (1985) Uptake of High Density Lipoproteins-associated apoprotein A-I and cholesterol esters by 16 tissues in the rat in vivo. J. Biol. Chem. 260, 744–750.Google Scholar
- 5.Pritchard PH, Mah E, McLeod R, Frohlich J and Lacko AG (1985) Lecithin: cholesterol acyltransferase in a patient with Tangier disease. Fed. Proc. 44, 1786Google Scholar
- 6.Rail SC, Weisengraber KH, Mahley RW, Ogawa Y, Fielding CJ, Utermann G, Haas J, Steinmetz, Menzel H-J, Assmann G. (1984) Abnormal lecithin:cholesterol acyltransferase activation by a human apolipoprotein A-I variant in which a single lysine residue is deleted. J. Biol. Chem. 259, 10063–10070.Google Scholar