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Statistical Analysis of Drug Disposition Data

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Drug Studies in the Elderly

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Abstract

Pharmacokinetics has become a rigorous science that attempts to relate the interaction of a drug with the biological environment into which it is introduced. Such a relationship is often described by proposing a mathematical model of the system and then using the data to define values for the unknown model parameters. Aris1 points out that “being derived from ‘modus’ (a measure) the word ‘model’ implies a change in representation.” That is, a model attempts to organize observations or measurements of the system under investigation into a form useful for hypothesis testing. The model parameters, which frequently must be determined from the observed data, function as measures for comparison of results within and between experiments. Based on this criterion, at least three tasks confront the analysts when faced with a data set: (1) to define a parametric model that best describes the system under investigation, (2) to estimate values for unknown model parameters, and (3) to determine whether the proposed model is a good or bad prototype of the system under investigation.

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Author information

Authors and Affiliations

  1. Laboratory of Mathematical Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA

    David G. Covell

  2. Clinical Pharmacokinetics Research Laboratory, Pharmacy Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Prem K. Narang

Authors
  1. David G. Covell
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  2. Prem K. Narang
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Editor information

Editors and Affiliations

  1. Department of Geriatrics Cedars-Sinai Medical Center, University of California-Los Angeles School of Medicine, 90048, Los Angeles, California, USA

    Neal R. Cutler M.D. (Director) (Director)

  2. Clinical Pharmacokinetics Research Laboratory Pharmacy Department Clinical Center, National Institutes of Health, 20892, Bethesda, Maryland, USA

    Prem K. Narang Ph.D. (Supervisor) (Supervisor)

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© 1986 Plenum Publishing Corporation

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Covell, D.G., Narang, P.K. (1986). Statistical Analysis of Drug Disposition Data. In: Cutler, N.R., Narang, P.K. (eds) Drug Studies in the Elderly. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1253-6_20

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  • DOI: https://doi.org/10.1007/978-1-4684-1253-6_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1255-0

  • Online ISBN: 978-1-4684-1253-6

  • eBook Packages: Springer Book Archive

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