Abstract
Drugs used to treat Parkinson’s disease fall into six main categories: (1) levodopa; (2) extracerebral decarboxylase inhibitors; (3) artificial dopamine agonists; (4) monoamine oxidase inhibitors; (5) anticholinergic agents; and (6) amantadine. Levodopa is the cornerstone of Parkinsonism disease treatment. The other five drug classes are useful supplements or occasional alternatives to levodopa.
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References
Evans MA, Triggs EJ, Broe GA, et al: Systemic availability of orally administered L-Dopa in the elderly parkinsonian patient. Eur J Clin Pharmacol 1980; 17: 215–221.
Evans MA, Broe GA, Triggs EJ, et al: Gastric emptying rate and the systemic availability of levodopa in the elderly parkinsonian patient. Neurology 1981; 31: 1288–1294.
Wurtman RJ, Hirsch MJ, Growdon JH: Lecithin consumption raises serum free choline levels. Lancet 1977; 2: 68.
Nutt JG, Woodward WR, Hammerstad JP, et al: The “on-off” phenomenon in Parkinson’s disease. N Engl J Med 1984; 310: 483–488.
Nutt JG, Fellman JH: Pharmacokinetics of levodopa. Clin Neuropharnuacol 1984; 7: 35–49.
Ward CD, Trombley IK, Caine DB, et al: L-dopa decarboxylation in chronically treated patients. Neurology 1984; 34: 198–201.
Schwab RS, England AC, Poskanzer DC et al: Amantadine in the treatment of Parkinson’s disease. JAMA 1969; 208: 1168–1170.
Cotzias GC, Papavasiliou MD, Tolosa ES, et al: Treatment of Parkinson’s disease with Aporphines. N Engl J Med 1976; 294: 567–572.
Schran HF, Bhuta SI, Schwarz HJ, et al: The pharmacokinetics of bromocriptine in man, in Goldstein M, Caine DB, Lieberman A, Thorner ML (eds): Ergot Compounds and Brain Function: Neuroendocrine and Neuropsychiatrie Aspects. New York, Raven Press, 1980, pp 125–139.
Burns RS, Caine DB: Disposition of dopaminergic ergot compounds following oral administration, in Caine DB, Horowski R, McDonald RJ, et al (eds): Lisuride and Other Dopamine Agonists. New York, Raven Press, 1983, pp 153–160.
Humpel M, Nieuweboer B, Wendt H: Radioimmunoassay of plasma lisuride in man following intravenous and oral administration of lisuride hydrogen maleate: Effects on plasma prolactin level. Eur] Clin Pharmacol 1981; 20: 47–51.
Glover V, Sandler M, Owen F, et al: Dopamine is a monoamine oxidase B substrate in man. Nature 1977; 265: 80–81.
Schachter M, Marsden CD, Parkes D, et al: Deprenyl in the management of response fluctuations in patients with Parkinson’s disease on levodopa. J Neurol Neurosurg Psychiatry 1980; 43: 1016–1021.
Chiba K, Trevor A, Castagnoli N: Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase. Biochem Biophys Res Commun 1984; 120: 574–578.
Lees AJ, Kohout LJ, Shaw KM, et al: Deprenyl in Parkinson’s disease. Lancet 1977; 2: 791–795.
Rinne UK, Siirtola T, Sonninen V: t.-Deprenyl treatment of on-off phenomena in Parkinson’s disease. J Neural Transmission 1978; 43: 253–262.
Eisler T, Teravainen H, Nelson R, et al: Deprenyl in Parkinson’s disease. Neurology 1981; 31: 19–23.
Duvoisin RC: Cholinergic—anticholinergic antagonism in Parkinsonism. Arch Neurol 1967; 17: 124–136.
Farnebo L, Fuxe K, Hamberger B, et al: Effect of some antiparkinsonian drugs on catecholamine neurons. J Pharm Pharmacol 1970; 22: 733–737.
Quinn NP: Anti-parkinsonian drugs today. Drugs 1984; 28: 236–262.
Burke RE, Fahn S: Pharmacokinetics of trihexyphenidyl after acute and chronic administration. Ann Neural 1982; 12: 94.
Whitehouse PJ, Price DL, Clarke AW, et al: Alzheimer’s disease: evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann Neurol 1981; 10: 122–126.
Pacifici GM, Nadini M, Ferari P: Effect of amantadine on drug-induced parkinsonism: relationship between plasma levels and effect. Br J Clin Pharmacol 1976; 3: 883–889.
Montanari C, Ferrari P, Bavazzano A: Urinary excretion of amantadine by the elderly. Eur J Clin Pharmacol 1975; 8: 349–351.
Kurland LT, Kurtzke JF, Goldberg ID: Epidemiology of Neurologic and Sense Organ Disorders. Cambridge, MA, Harvard University Press, 1973, pp 436.
Fluckiger E, Briner U, Enz A, et al: Dopaminergic ergot compounds: an overview, in DB Calne et al (eds): Lisuride and Other Dopamine Agonists. New York, Raven Press, 1983, pp 1–9.
Larsen TA, Newman R, Le Witt P, et al: Severity of Parkinson’s disease and the dosage of bromocriptine. Neurology 1984; 34: 795–7.
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© 1986 Plenum Publishing Corporation
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Calne, D.B., Laihinen, A. (1986). Pharmacological Treatment of Parkinson’s Disease. In: Cutler, N.R., Narang, P.K. (eds) Drug Studies in the Elderly. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1253-6_15
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DOI: https://doi.org/10.1007/978-1-4684-1253-6_15
Publisher Name: Springer, Boston, MA
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