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Purine and Pyrimidine Metabolism in Man V pp 305–309Cite as

Characterization of Hydroxyurea (HYU) Resistant S49 T Lymphoma Cells

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 195B))

Abstract

Ribonucleoside diphosphate reductase (EC 1.17.4.1) catalyzes the reduction of ribonucleoside diphosphates to their deoxyribonucleotide counterparts for DNA synthesis (1). The mammalian enzyme Is composed of two subunits: the M1 protein has binding sites that are Involved In the complex allosteric feedback control of the enzyme (2,3); whereas, the M2 subunit contains the free radical binding site of hydroxyurea (4,5).

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Author information

Authors and Affiliations

  1. Department of Medicine, University of Chicago, Chicago, IL, 60637, USA

    Daniel A. Albert & Lorraine J. Gudas

  2. Pharmacology Department, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, 02115, USA

    Daniel A. Albert & Lorraine J. Gudas

Authors
  1. Daniel A. Albert
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  2. Lorraine J. Gudas
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Editor information

Editors and Affiliations

  1. University of California, San Diego La Jolla, California, USA

    W. L. Nyhan

  2. Scripps Clinic and Research Foundation, La Jolla, California, USA

    L. F. Thompson

  3. M. R. C. Clinical Research Center, Harrow, UK

    R. W. E. Watts

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© 1986 Plenum Press, New York

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Albert, D.A., Gudas, L.J. (1986). Characterization of Hydroxyurea (HYU) Resistant S49 T Lymphoma Cells. In: Nyhan, W.L., Thompson, L.F., Watts, R.W.E. (eds) Purine and Pyrimidine Metabolism in Man V. Advances in Experimental Medicine and Biology, vol 195B. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-1248-2_48

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  • DOI: https://doi.org/10.1007/978-1-4684-1248-2_48

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-1250-5

  • Online ISBN: 978-1-4684-1248-2

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