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Synthesis and Turnover of Purine Nucleoside Phosphorylase in Human Lymphocytes

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Book cover Purine and Pyrimidine Metabolism in Man V

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 195B))

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Abstract

The inherited deficiency of purine nucleoside Phosphorylase results in severe T cell immunodeficiency disease1. We have studied the synthesis of purine nucleoside Phosphorylase during phytohumagglutinin induced T cell transformation and have examined the turnover of purine nucleoside Phosphorylase in the human lymphoblast WI-L2.

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References

  1. E.R. Giblett, A.J. Ammann, D.W. Wara, R. Sandman, and L.K. Diamond, Nucleoside Phosphorylase deficiency in a child with severely defective T cell immunity and normal B-cell immunity, Lancet, 1: 1010 (1975).

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Authors and Affiliations

  1. Departments of Pediatrics and Medical Biochemistry, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada

    Floyd F. Snyder, Kuldeep Neote, Eddie Kwan & Ellen R. Mably

Authors
  1. Floyd F. Snyder
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  2. Kuldeep Neote
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  3. Eddie Kwan
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  4. Ellen R. Mably
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Editor information

Editors and Affiliations

  1. University of California, San Diego La Jolla, California, USA

    W. L. Nyhan

  2. Scripps Clinic and Research Foundation, La Jolla, California, USA

    L. F. Thompson

  3. M. R. C. Clinical Research Center, Harrow, UK

    R. W. E. Watts

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© 1986 Plenum Press, New York

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Snyder, F.F., Neote, K., Kwan, E., Mably, E.R. (1986). Synthesis and Turnover of Purine Nucleoside Phosphorylase in Human Lymphocytes. In: Nyhan, W.L., Thompson, L.F., Watts, R.W.E. (eds) Purine and Pyrimidine Metabolism in Man V. Advances in Experimental Medicine and Biology, vol 195B. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-1248-2_40

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  • DOI: https://doi.org/10.1007/978-1-4684-1248-2_40

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-1250-5

  • Online ISBN: 978-1-4684-1248-2

  • eBook Packages: Springer Book Archive

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