Abstract
An Inherited deficiency of adenosine deaminase (ADA) Impairs specifically the development of the human lymphoid system (reviewed In 1). In ADA deficient children, plasma deoxyadenosine (dAdo) concentrations reach 1-2 μM. Micromolar concentrations of dAdo are toxic toward Immature human T-lymphocytes, and toward T-Iymphoblastoid cell lines grown In medium supplemented with deoxycoformycin, a tight binding ADA Inhibitor.1 Compared to other cell types, human T-lymphoblasts preferentially phosphorylate dAdo and accumulate dATP.
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© 1986 Plenum Press, New York
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Carson, D.A., Carrera, C.J., Kubota, M., Wasson, D.B., Iizasa, T. (1986). Genetic Analysis of Deoxyadenosine Toxicity in Dividing Human Lymphoblasts. In: Nyhan, W.L., Thompson, L.F., Watts, R.W.E. (eds) Purine and Pyrimidine Metabolism in Man V. Advances in Experimental Medicine and Biology, vol 195B. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-1248-2_31
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DOI: https://doi.org/10.1007/978-1-4684-1248-2_31
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